This fellowship will allow the applicant to continue his studies into understanding and intervening in osteoarthritis. He will use a combination of observational studies and clinical trials to achieve this purpose.
A Multicentre Randomised Controlled Trial Of Probiotic And Peanut Oral Immunotherapy For The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$2,887,302.00
Summary
A curative treatment for food allergy is required to prevent deaths and improve management. We recently trialed a new treatment for peanut allergy that was highly effective. Over 80% of children treated with Probiotic and Peanut Oral ImmunoTherapy (PPOIT) tolerated peanut as compared to 4% of children who received placebo. We now plan a larger multicentre trial to confirm these findings. If successful, we will have established a new treatment for peanut allergy and possibly all food allergies.
Chronic Knee Pain: Neuroscience Meets Exercise For Pain Relief
Funder
National Health and Medical Research Council
Funding Amount
$286,891.00
Summary
Chronic knee pain impacts negatively on health, finances and quality of life. Exercise is the most efficacious intervention yet can be painful or uninteresting. Current rehabilitation methods fail to address the dysfunctional way the brain controls muscles in people with pain that may contribute to ongoing disability. This study uses novel, innovative techniques in the form of virtual reality combined with exercise to reduce pain, boredom, and critically, target dysfunctional movement control.
Targeted Pelvic Floor Muscle Training For Urinary Incontinence After Radical Prostatectomy: A Randomised Controlled Trial With Embedded Physiological Studies
Funder
National Health and Medical Research Council
Funding Amount
$966,377.00
Summary
Prostatectomy is a common treatment for the most common cancer in men. Survival is good, but many develop debilitating urinary incontinence. Past pelvic floor muscle training has had limited effect, but recent work has changed understanding of how muscles control continence and compensate for surgery. This clinical trial compares innovative training individually tailored to optimise continence, usual exercise and no treatment, and aims to identify men most likely to benefit from treatment.
This research program aims to utilise three new clinical trials to treat pain from osteoarthritis of the knee and hand. These treatments use existing medications, but for new indications. This project will determine if these treatments reduce pain and slow structural changes over two years of treatment. It also has the potential to develop the first treatment for osteoarthritis which changes the natural course of the disease rather than merely treating symptoms.
Hype Or Hope? Platelet-Rich Plasma As A Symptom- And DisEaSe-modifying Treatment FOR Knee OstEoarthritis - The RESTORE Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,400,359.00
Summary
Knee osteoarthritis (OA) is a major public health problem worldwide with no cure. Thus safe and effective treatments that reduce symptoms and slow structural disease progression are needed. This clinical trial aims to test the effects of injections of platelet-rich plasma (a blood product) into the knee on pain and joint structure in 288 people with knee OA. The results will provide high quality evidence to determine whether platelet rich plasma should be used to treat knee OA.
Evaluation Of A Tailored Online Hospital And Post-discharge Smoking Cessation Program For Orthopaedic Trauma Surgery Patients
Funder
National Health and Medical Research Council
Funding Amount
$370,818.00
Summary
Smoking causes serious post-surgery complications and may lengthen recovery time. Hospitalisation is an ideal opportunity to encourage quitting to patients who smoke. We have found high rates of smoking among trauma surgery patients, and high interest to quit, yet few reported receiving advice to quit. We have designed an online quit support program for patients. The program is expected to help patients to quit smoking, leading to improvements in their recovery and general health.
First Line Treatments For Common Musculoskeletal Conditions: Establishing Effectiveness And Cost-effectiveness
Funder
National Health and Medical Research Council
Funding Amount
$452,583.00
Summary
Dr Christine Lin is an outstanding young researcher whose research focuses on investigating the effectiveness and cost-effectiveness (value-for-money) of treatments for common musculoskeletal conditions. These conditions, such as back pain and fracture, are a major cause of disability in Australia and abroad. Dr Lin will lead a series of large clinical studies with an aim to improve patient outcomes while minimising the economic burden on the individual, health system and society.
Preventing Early-onset Pneumonia In Indigenous Infants Through Maternal Immunisation: A Multi-centre Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$3,210,618.00
Summary
We plan a study where Indigenous pregnant women will be immunised with a licensed vaccine to determine if it prevents acute lung infections in their children. A randomised design will be used based on our previous work. We will also undertake 2 novel sub-studies on infant immune function and reasons why women refuse immunisation. If successful, this study will alter immunisation policy and prevent lung infections and future chronic lung diseases that are common in Indigenous children and adults.
Impact On Caesarean Rates Following Injections Of Sterile Water (ICARIS) – A Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$472,692.00
Summary
The rising number of caesarean section births is causing concern across the country. Injections of small amounts of sterile water into the lower back provide relief to women who have back pain in labour. A review of the research found that administration of these injections may be associated with a reduction in caesarean section rates. Four Queensland hospitals, will conduct the largest study to date to determine if sterile water injections can decrease caesarean section rates without increasing ....The rising number of caesarean section births is causing concern across the country. Injections of small amounts of sterile water into the lower back provide relief to women who have back pain in labour. A review of the research found that administration of these injections may be associated with a reduction in caesarean section rates. Four Queensland hospitals, will conduct the largest study to date to determine if sterile water injections can decrease caesarean section rates without increasing morbidity for the woman or her baby.Read moreRead less