Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored ....Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored to selectively kill microbes with reduced likelihood of developing resistance by using synergies between inorganic nanoparticles and antimicrobial peptides. This technology could be used to prevent infections and biofilms on surfaces in a wide range of future applications, such as medical / veterinary devicesRead moreRead less
A Randomised Controlled Trial Of CPAP Versus Oral Appliance In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$416,155.00
Summary
Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 25% of women and 9% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. When associated with symptoms, termed Obstructive Sleep Apnoea Syndrome, it occurs in 4% of men and 2% of women in middle age. OSA is recognised as a serious public health problem. Continuous Positive Airway ....Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 25% of women and 9% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. When associated with symptoms, termed Obstructive Sleep Apnoea Syndrome, it occurs in 4% of men and 2% of women in middle age. OSA is recognised as a serious public health problem. Continuous Positive Airway Pressure is the gold standard treatment, and has been demonstrated to produce major health benefits. However, there is growing evidence supporting the use of oral appliances to treat OSA, which are potentially simpler to use. It is thought that these work by enlarging the throat passage. Recent practice guidelines recommend their use as a first line treatment for mild to moderate OSA. The aim of this project is to directly compare the health benefits achievable with these therapies, taking into account patient compliance and preference, and will assist in the development of protocols for the use of these treatments in clinical practice.Read moreRead less
Orientated biointerfacing of cell-mimetic nanoparticles. The project aims to create next-generation cell-mimetic nanotechnology by providing in-depth understandings and precise control over cell membrane coating orientation of biomimetic nanoparticles. Our approach is to design and develop new synthetic and analytic strategies to construct and quantify orientated biointerfacing. This will generate new knowledge and patentable methodologies related to orientated biomimetic nanoparticles. Expected ....Orientated biointerfacing of cell-mimetic nanoparticles. The project aims to create next-generation cell-mimetic nanotechnology by providing in-depth understandings and precise control over cell membrane coating orientation of biomimetic nanoparticles. Our approach is to design and develop new synthetic and analytic strategies to construct and quantify orientated biointerfacing. This will generate new knowledge and patentable methodologies related to orientated biomimetic nanoparticles. Expected outcomes include significant contributions to Australia's scholarly outputs, enhanced national capacity in disruptive nanotechnology, new opportunities for national value-add material manufacturing, and long-term benefits to biomedical and veterinary industries through new materials and nanotechnologies.
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HABIT-ILE: A Randomised Trial Of Hand Arm Bimanual Intensive Training Including Lower Extremity Training For Children With Bilateral Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$1,100,903.00
Summary
In Australia, 35,000 people have cerebral palsy, and between 60-70% experience difficulties with movement on both sides of their body. There are currently no effective interventions for children with bilateral CP to improve their ability to use their hands, walk and perform daily life tasks. We have promising data about a new intervention, called HABIT-ILE, which we will test in 80 children with cerebral palsy and compare results to usual care.
New And Improved Treatment Strategies For Neonatal Seizures
Funder
National Health and Medical Research Council
Funding Amount
$883,209.00
Summary
Around 10% of neonates in Australia are diagnosed with seizures each year. Seizures worsen neurodevelopmental outcome following hypoxic brain injury. Despite evidence of the limited effectiveness and potential neurotoxicity of current anti-seizure medication, treatment has not changed for many decades. The objective of this study is to optimise treatment of neonatal seizures with a compound that is effective and does not cause harm, or indeed provides neuroprotection for the compromised brain.
I am a stem cell scientist working on the biology of human embryonic stem cells and their differentiation into cells of mesodermal (blood, endothelium and cardiomyocyte) and endodermal (pancreatic islet cells) lineages.
AI Assisted Continuous Flow Electrochemistry for Pharmaceutical Manufacture. This project aims to develop new chemical manufacturing processes for pharmaceutical products. In collaboration with Sun Pharma, it will tackle the challenge of replacing expensive and toxic chemicals in industrial reactions, to lower cost of manufacturing and improve its sustainability profile. Central to the realisation of this ambition is the use of electrocatalysis, machine learning and implementation of advanced co ....AI Assisted Continuous Flow Electrochemistry for Pharmaceutical Manufacture. This project aims to develop new chemical manufacturing processes for pharmaceutical products. In collaboration with Sun Pharma, it will tackle the challenge of replacing expensive and toxic chemicals in industrial reactions, to lower cost of manufacturing and improve its sustainability profile. Central to the realisation of this ambition is the use of electrocatalysis, machine learning and implementation of advanced continuous flow methods. These electricity- and technology-driven reactions will develop new strategies for the generation of important classes of molecules relevant to the Australia’s pharmaceutical sector, as well as their manufacture at industrially relevant scales.Read moreRead less