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A Comparison Of Arthroscopic Synovial Biopsy Based Targeted Biologic Therapy Versus Conventional Therapy In Rheumatoid Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better dise ....This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better disease control than the currently prevalent approach.Read moreRead less
Molecular Mechanisms Of Ivermectin Resistance In The Ectoparasitic Mite, Sarcoptes Scabiei
Funder
National Health and Medical Research Council
Funding Amount
$289,561.00
Summary
A largely neglected parasitic disease, scabies is a significant disease of children, particularly in remote Aboriginal communities in northern Australia. The recent emergence of ivermectin resistance threatens future control of scabies. This research explores the genetic basis of ivermectin resistance in the scabies mite, developing molecular markers to identify the emergence of resistance in the community, leading to improved tools for resistance management and sustainable treatment strategies.
Improving Alcohol Treatment Outcomes: The Impact Of Client, Intervention And System Variables On Treatment Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$1,525,879.00
Summary
Patient outcomes are significantly influenced by a number of factors including the characteristics of the patient, the type of treatment provided, and the characteristics of the system in which care is delivered. This study aims to determine how these factors influence outcomes for people seeking treatment for alcohol dependence. It will provide critical information for policy makers on which to base minimum service standards.
Characterisation Of CFAE Wavefront Propogation In Human Persistent AF
Funder
National Health and Medical Research Council
Funding Amount
$418,612.00
Summary
Atrial fibrillation can be eliminated by a relatively new treatment called catheter ablation, which involves modification of the electrical properties of the heart using thin wires (catheters) passed up from the leg. Targeting areas where catheters record abnormal electrical activity improves results of catheter ablation, although it is uncertain what these recordings represent. The aim of this study is to characterize these abnormal electrical signals in an attempt to improve ablation outcomes.
Optimising Therapy In Anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
ANCA vasculitis is a rare autoimmune condition causing inflammation in small blood vessels, that can lead to organ failure and death. This research will help identify the best treatment approach for different subgroups of patients and the best timing of certain treatments. We will also explore patient symptoms and experience of this condition, and how this relates to disease activity, damage and medication effects.
Addressing Menstrual Health To Improve Adolescent Health And Development: Co-design Of An Acceptable And Scalable School-based Strategy In Myanmar
Funder
National Health and Medical Research Council
Funding Amount
$986,024.00
Summary
Our work in Myanmar has identified menstrual health to be a critical issue impacting on education and wellbeing for girls. We aim to produce an evidence-based and scalable strategy to improve adolescent menstrual health in Myanmar by: exploring needs and opportunities to address menstrual health across diverse school settings; Co-designing with girls and key stakeholders a strategy to improve menstrual health in Myanmar; piloting and evaluating the intervention package across diverse schools.
Investigating The Impact Of Ethnicity On Asthma: Determining Risk Factors, Modifiers, Clinical Phenotypes, And Differential Response To Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$125,396.00
Summary
Asthma is a common disease in Australia with significant burden on both patients and the public healthcare system. Patients from ethnic minorities have disproportionately worse outcomes and current treatment guidelines are based on research among Caucasian-based populations. My PhD will describe differences in clinical characteristics, outcomes and response to treatment between ethnic groups. The overall aim of my PhD is to develop highly effective asthma treatment for ethnic minorities.
Testing A Combination Of 2 Clinical Drugs, An IAP Inhibitor And P38 Inhibitor, To Treat AML
Funder
National Health and Medical Research Council
Funding Amount
$200,890.00
Summary
Current treatments only cure 50% of Acute Myeloid Leukaemia (AML) patients, and novel approaches to treatment are desperately needed to improve survival of patients with leukaemia. One new drug, Birinapant, is currently being tested in clinical trials to treat AML. I have found that some AMLs are resistant to Birinapant treatment but the addition of a second drug (called “p38 inhibitors”) can now overcome this resistance. I will test how effective combining these two drugs can be to treat AML.
The focus of this research is the integration of innovative evidence-based, personalised physical activity behaviour change programs that can be delivered via print, web/email, telephone and mobile text-messaging into clinical settings. This research will evaluate the effectiveness of initiating these interventions at the point of interaction between patients and health professionals in current clinical environments for the purpose of improving physical activity levels amongst inactive patients.
Investigation Of Dysfunction Of SIGMAR1 In Transgenic Mouse Models, A Novel Gene Implicated In Neurodegeneration
Funder
National Health and Medical Research Council
Funding Amount
$492,119.00
Summary
At present, there are no effective therapies for frontotemporal dementia or motor neuron disease. We have identified the SIGMAR1 gene as having a crucial role for these diseases. More importantly, there are therapeutically relevant small molecule drugs that are known to modulate the activity of this gene. We aim to determine the efficacy of pharmacological modulation of Sigma-1 receptor activity in mouse models of dementia.