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OzENTER-TBI_Australia-Europe NeuroTrauma Effectiveness Research In TBI Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$368,823.00
Summary
The OzENTER-TBI project will advance the care of traumatic brain injury (TBI) patients. Researchers will collaborate with the European CENTER-TBI project to characterise and classify TBI. They will contribute to large data sets which will explore the differences between sites and countries on TBI outcomes. They will also investigate emerging technologies in TBI. It will have a profound impact on treatment, health care costs and ultimately quality of life for TBI patients worldwide.
Indigenous Mental Health Model Of Care: RCT Based On A Trans-diagnostic CBT Program Co-designed With Community
Funder
National Health and Medical Research Council
Funding Amount
$996,217.00
Summary
We propose to develop an Indigenous Model of Mental Health Care (IMMHC) that encompasses psychological therapy and cultural healing practices developed in consultation with local, participating Indigenous communities, that will for the first time treat highly prevalent mood and anxiety disorders in Indigenous Australians.
Development And Epilepsy - Strategies For Innovative Research To Improve Diagnosis, Prevention And Treatment In Children With Difficult To Treat Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$456,083.00
Summary
By deciphering pathophysiological mechanisms in epileptogenic developmental disorders and developing mechanism-related, and advanced therapeutic strategies, we expect to discover novel genes and related molecular pathways that are involved in epilepsy and similar disorders. DESIRE will also help preventing the development of the disease after potentially epileptogenic brain insults.
From Brain Maps To Mechanisms: Modelling The Pathophysiology Of Dementia
Funder
National Health and Medical Research Council
Funding Amount
$604,513.00
Summary
As the brain ages, the relationship between its structure and function also changes. In this study, I will use detailed computational modelling and extensive analyses of brain dynamics to improve interventional strategies by: 1. Characterising healthy and unhealthy brain dynamics during ageing; 2. Classifying the various subtypes of pathological dynamics; and 3. Predicting pathological neurodegeneration by identifying the earliest signs of perturbations in healthy ageing.
The Effect Of Chronic Intermittent Alcohol Consumption On The Precipitation Of Dementia.
Funder
National Health and Medical Research Council
Funding Amount
$604,644.00
Summary
This proposal examines the relationship between chronic alcohol intake and alcohol-related dementia, and potential interventions for the treatment of alcohol related dementia.
ACERH- Inovative Analyses Of Health Insurance, Ageing And The Economic Burden Of Illness And Injury
Funder
National Health and Medical Research Council
Funding Amount
$4,500,000.00
Summary
An inter-university collaborative research centre – the Australian Centre for Economic Research on Health (ACERH) – will be established, undertaking applied health economics research within three research programs: health insurance; ageing; and the economic analysis of illness and injury. ACERH will develop a unique, unit record, linked data set, including data from private health insurance partners, providing longitudinal data on health service utilisation in both public and private sectors.
Vascular Cognitive Risk Score: Quantifying The Vascular Burden In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$627,180.00
Summary
What causes dementia in a patient presenting to a clinic is often uncertain. While there are exciting potential treatments in the pipeline, we need to understand the cause of the disease in a specific patient to make correct treatment decisions. Stroke and other vascular diseases of the brain cause a significant proportion of dementia in the community. Using MRI scanning technology, this project will quantify this burden in a given patient by developing a ‘vascular cognitive risk' (VCR) score.
Novel Targeted Degradable Multifunctional Poly(vinyl-co-ester) Nanoparticles For Alzheimer’s Disease Applications
Funder
National Health and Medical Research Council
Funding Amount
$601,940.00
Summary
Novel biodegradable polymeric nanoparticles for efficient and targeted delivery of Alzheimer related agents to the brain will be developed. The nanocarriers will be fabricated from biocompatible multifunctional compounds and possess the capability to co-deliver diagnostic and therapeutic agents across the blood-brain barrier. These systems are expected to become a new efficient class of brain delivery systems.
Dementia Associated To Diabetes: Prevention Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$719,770.00
Summary
Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.
ACTION - Aggression In Children: Unravelling Gene-environment Interplay To Inform Treatment
Funder
National Health and Medical Research Council
Funding Amount
$453,871.00
Summary
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. ACTION will deliver an overarching framework that combines a thorough understanding of pathways leading to aggression with a map of current gaps, best practices on clinical, ethical, legal, and social issues.