High Strength Steel Protection Bollards. Terrorist attacks cost Australians much human grief and millions of dollars. Prevention of an attack is paramount. Passive road bollards are commonly used to stop a vehicle approaching and/or entering security sensitive infrastructure. Thin-walled tubes are used to manufacture such bollards. However there is a lack of knowledge about their behaviour, and in particular high strength alloy steel bollards, when subjected to impact loads. The investigators wi ....High Strength Steel Protection Bollards. Terrorist attacks cost Australians much human grief and millions of dollars. Prevention of an attack is paramount. Passive road bollards are commonly used to stop a vehicle approaching and/or entering security sensitive infrastructure. Thin-walled tubes are used to manufacture such bollards. However there is a lack of knowledge about their behaviour, and in particular high strength alloy steel bollards, when subjected to impact loads. The investigators will apply their extensive knowledge in thin-walled tubular structures to establish the most economical means of designing high strength bollards. This knowledge will be transferred into design standards and Australia's limited defence resources.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Integrating Mobility on Demand in urban transport infrastructures. Australia’s major cities are substantially challenged for public transport services due to the dispersed and low population densities, and thus, roads are at or beyond their capacity. Smarter demand-responsive public transport services are therefore needed. This project studies the viability of such a service under a variety of scenarios.
iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour polic ....iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour policies and programs. By controlling for the influence of the built and social environment, the project will provide the necessary support to justify these policy interventions and to identify key improvements for their delivery, supporting more sustainable and healthy lifestyles for Australia's children.Read moreRead less
Multidrug Resistance Protein 1 Inhibitors To Sensitise Cancers To Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$840,166.00
Summary
Multidrug resistance protein 1 (MRP1) is often present at high levels in cancer cells, where it pumps chemotherapy drugs back out, causing drug resistance. Inhibitors that block MRP1 would increase the effectiveness of chemotherapy. We have developed MRP1 inhibitors with promising activity in cancer cells and mouse tumours and will now develop these inhibitors for clinical application and commercialisation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0228900
Funder
Australian Research Council
Funding Amount
$603,000.00
Summary
Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and b ....Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and barriers can perform safely when subjected to very heavy traffic and impact loads under laboratory and typical service conditions. This application seeks funds for establishing a unique hi-tech testing facility in Australia vital for advancing such infrastructure technology.Read moreRead less
The development and application of an evaluation framework to assess transport, health and economic impacts of new urban cycling infrastructure. This project will develop and apply a more accurate and simpler approach to measure the impacts of new cycling infrastructure, than is currently available. This methodology will be applied to a new bicycle path to be built by the City of Sydney, demonstrating the full transport, environmental, health, and economic impacts on the community.
The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in pa ....The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in particular, children's exposure to ultrafine particles, thus reducing life long impacts, health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental and public health sustainability.Read moreRead less
Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In additio ....Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In addition, much needed Occupational Health & Safety information regarding vehicle rollover crashworthiness, which provide a safe work place environment for professional drivers and employees using vehicles, will be supplied to industry fleet managers, defence and emergency services.Read moreRead less
Comfort and ergonomics: Innovative seating solutions for commercial vehicles. Comfort and ergonomics: Innovative seating solutions for commercial vehicles. This project aims to develop a 6-degree-of-freedom seating system for commercial vehicles, including heavy duty trucks and mobile machinery, to reduce unwanted multiple directional vibrations to the driver’s body. Long-term exposure to vibrations from uneven road surfaces, vibrating tools, and vibrating machinery affects driver comfort, fatig ....Comfort and ergonomics: Innovative seating solutions for commercial vehicles. Comfort and ergonomics: Innovative seating solutions for commercial vehicles. This project aims to develop a 6-degree-of-freedom seating system for commercial vehicles, including heavy duty trucks and mobile machinery, to reduce unwanted multiple directional vibrations to the driver’s body. Long-term exposure to vibrations from uneven road surfaces, vibrating tools, and vibrating machinery affects driver comfort, fatigue and safety, and can also cause neck and shoulder pain, lower back injuries, and spinal injuries. The expected outcome of the project is a comfortable and ergonomic seating system that, agriculture, transportation, mining and construction vehicles, both in Australia and internationally, can widely use.Read moreRead less