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Scheme : Early Career Fellowships
Research Topic : transplantation tolerance
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    Investigation Into The Role Of Regulatory B Cells In Transplantation

    Funder
    National Health and Medical Research Council
    Funding Amount
    $400,385.00
    Summary
    Solid organ transplantation is the most effective therapy for treating organ failure and some cancer. However, a common complication that occurs is graft rejection. The current aim is to develop procedures that reduce the risk of graft rejection without the use of immunosuppressive drugs, which can be toxic and make recipients more susceptible to infection. We are investigating the ability of a cell that is part of the immune system to down-regulate over-reactive immune responses and therefore r .... Solid organ transplantation is the most effective therapy for treating organ failure and some cancer. However, a common complication that occurs is graft rejection. The current aim is to develop procedures that reduce the risk of graft rejection without the use of immunosuppressive drugs, which can be toxic and make recipients more susceptible to infection. We are investigating the ability of a cell that is part of the immune system to down-regulate over-reactive immune responses and therefore reduce rejection.
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    Funded Activity

    Rhesus Monkey Dendritic Cells For Transplant Tolerance.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $156,632.00
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    Funded Activity

    Tolerance Induction In Islet Cell Transplantation

    Funder
    National Health and Medical Research Council
    Funding Amount
    $282,793.00
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    Funded Activity

    Induction Of Islet Transplant Tolerance In A Humanised Mouse Model

    Funder
    National Health and Medical Research Council
    Funding Amount
    $374,552.00
    Summary
    The current treatment for type 1 diabetes (T1D) is insulin therapy, but it cannot fully prevent chronic complications. Also intensive insulin use increases the risk of fatal hypoglycemia. An emerging therapy which may overcome or at least reduce these problems is the transplantation of human islet cells. But preventing the immune system from rejecting these cell transplants is still a major challenge. This study will develop new therapeutic strategies to protect these transplants from rejection.
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    Adenosine Receptor And Transcriptional Determinants Of Ischaemia Tolerance With Ageing

    Funder
    National Health and Medical Research Council
    Funding Amount
    $219,187.00
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    Funded Activity

    Developing The Noval Peptide-based Diagnostics And Therapeudics For Coeliac Disease

    Funder
    National Health and Medical Research Council
    Funding Amount
    $179,708.00
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    Funded Activity

    The Role Of Environment And Innate Immunity In Autoimmune Disease.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $276,266.00
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    Funded Activity

    Induction Of Tolerance Using IL-2 Immune Complexes To Modulate Regulatory T Cell Response

    Funder
    National Health and Medical Research Council
    Funding Amount
    $282,008.00
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    Funded Activity

    Inhibition Of Human Anti-pig NK Cells By HLA-Expression

    Funder
    National Health and Medical Research Council
    Funding Amount
    $274,188.00
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    Funded Activity

    Fetal Immune Response To Vertical Transmission Of Toxoplasma Gondii

    Funder
    National Health and Medical Research Council
    Funding Amount
    $320,891.00
    Summary
    Toxoplasma gondii is a parasite that is a leading cause of human abortion and congenital infections of newborns. In addition, recent research implicates Toxoplasma in diagnoses of schizophrenia and other neuromental conditions. Study of Toxoplasma, it's transmission and effects of infection and development of tools such as vaccines and diagnostic technologies will lead to an improvement in health of mothers, newborns and the wider population.
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    Showing 1-10 of 32 Funded Activites

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