New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tack ....New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tackles this problem through a combination of organic and inorganic synthesis to develop new electrochromic dyes that may be attached to mesoporous titania.Read moreRead less
Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. ....Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. Using the combined expertise of the applicants, it is proposed to stereospecifically synthesise dinuclear complexes and study their DNA binding. This will greatly assist in the development of drugs that can selectively target genes and altered DNA.Read moreRead less
Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy ....Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy (the pyridine-2-carboxaldehyde isonicotinoyl hydrazone [PCIH] analogues) which show oral activity. These chelators undergo some interesting iron catalysed oxidation chemistry and it is vital that the mechanism of this reaction be elucidated to determine whether it will be of biological significance upon administration of these compounds as iron chelators.Read moreRead less
Spotlighting biologically active Iron (Fe) chelators within cells. Anti-cancer drugs that act in ways different from traditional chemotherapeutics offer hope in evading acquired drug resistance. Previously we have studied compounds that can enter cancer cells, bind iron and halt cellular proliferation. However, there are many sources of iron in cells and we do not know from where these iron chelators acquire their iron or how these iron complexes kill cancer cells. We will tackle this problem by ....Spotlighting biologically active Iron (Fe) chelators within cells. Anti-cancer drugs that act in ways different from traditional chemotherapeutics offer hope in evading acquired drug resistance. Previously we have studied compounds that can enter cancer cells, bind iron and halt cellular proliferation. However, there are many sources of iron in cells and we do not know from where these iron chelators acquire their iron or how these iron complexes kill cancer cells. We will tackle this problem by attaching light emitting probes to known iron chelators and mapping their location within cells with high resolution fluorescence microscopy. These experiments will spotlight the cellular location of these potential drugs bound to iron for the first time, providing crucial information on their mode of action.Read moreRead less
Intervalence Transfer in Dinuclear and Oligonuclear Polymetallic Assemblies. Mixed-valence compounds (such as the pigment Prussian Blue) have been known for over two centuries, and possess important conductivity, magnetic and spectral properties. Electron transfer between the elements of different valency (intervalence charge transfer, IVCT) gives rise to absorbances in the red or near-infrared region of the spectrum which provide fundamental information on the electron migration. By design of ....Intervalence Transfer in Dinuclear and Oligonuclear Polymetallic Assemblies. Mixed-valence compounds (such as the pigment Prussian Blue) have been known for over two centuries, and possess important conductivity, magnetic and spectral properties. Electron transfer between the elements of different valency (intervalence charge transfer, IVCT) gives rise to absorbances in the red or near-infrared region of the spectrum which provide fundamental information on the electron migration. By design of target di- and higher nuclearity polymetallic species, the project will study IVCT phenomena to understand electron movement, allowing rational development of applicable materials such as catalysts, light-activated devices and non-linear optical materials.Read moreRead less
Development of New Materials Based on Multinuclear Ruthenium Complexes. The program aims to design new materials for use in applications such as catalysis and light-activated devices (including light harvesting or solar energy conversion), for the detection and analysis of specific small molecules and anions of particular interest, and to provide an insight to the operation of biological systems such as metal-containing enzymes. The particular molecules will also be investigated for the developm ....Development of New Materials Based on Multinuclear Ruthenium Complexes. The program aims to design new materials for use in applications such as catalysis and light-activated devices (including light harvesting or solar energy conversion), for the detection and analysis of specific small molecules and anions of particular interest, and to provide an insight to the operation of biological systems such as metal-containing enzymes. The particular molecules will also be investigated for the development of a new type of therapeutic agent for the treatment of a range of diseases, with a particular interest in this work on a drug for the treatment of HIV-AIDS. Read moreRead less
The fate of copper in atom transfer radical reactions. Copper (Cu) complexes of poly-amine ligands have emerged as extremely active homogeneous catalysts in atom transfer radical reactions, forming organic radicals from alkyl halide precursors, and they are now employed extensively in polymer and organic chemistry. The catalyst cycles between its Cu(I) and Cu(II) oxidation states reversibly yet both forms are susceptible to side reactions, particularly with solvents which can lead to loss of cat ....The fate of copper in atom transfer radical reactions. Copper (Cu) complexes of poly-amine ligands have emerged as extremely active homogeneous catalysts in atom transfer radical reactions, forming organic radicals from alkyl halide precursors, and they are now employed extensively in polymer and organic chemistry. The catalyst cycles between its Cu(I) and Cu(II) oxidation states reversibly yet both forms are susceptible to side reactions, particularly with solvents which can lead to loss of catalytic activity. This project aims to apply a multifaceted approach to interrogate the catalysts in both their Cu(I) and Cu(II) oxidation states and identify for the first time the pathways that lead to undesirable side reactions and provide new ways of optimising catalyst performance.Read moreRead less
Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential. Resistance by cancers to established chemotherapeutics is a growing problem in the community and one that demands the development of new strategies. Chelators that target the essential element iron within cancer cells represent a novel and promising approach to this problem. The Chief Investigators represent a unique combination of expertise in coordination chemistry and the biochemistry of iron chelati ....Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential. Resistance by cancers to established chemotherapeutics is a growing problem in the community and one that demands the development of new strategies. Chelators that target the essential element iron within cancer cells represent a novel and promising approach to this problem. The Chief Investigators represent a unique combination of expertise in coordination chemistry and the biochemistry of iron chelation. They have discovered and characterised new chelators that show marked anticancer activity, and act by a new mechanism that overcomes problems of resistance. In this project they will pursue a course that will lead to a greater understanding of how these compounds work with the outcome that new effective anticancer drugs may emerge.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100197
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
National magnetochemical facility. New magnetic materials of the molecular or biological types are quite different to traditional metal oxide magnets widely used, for example, in recording devices. They are very important from the perspective of understanding fundamental properties at low temperatures, in high magnetic fields, or when irradiated by light, but they are also showing promise in a range of applications, such as memory devices and smart cards and in the new area of spintronics and m ....National magnetochemical facility. New magnetic materials of the molecular or biological types are quite different to traditional metal oxide magnets widely used, for example, in recording devices. They are very important from the perspective of understanding fundamental properties at low temperatures, in high magnetic fields, or when irradiated by light, but they are also showing promise in a range of applications, such as memory devices and smart cards and in the new area of spintronics and molecular computers. The magnetochemical projects described here, that require the new equipment being sought, are fundamental in nature but will provide the underpinning of future nanomagnetic materials.Read moreRead less
Creating sustainable employment for disadvantaged and vulnerable groups . This project aims to address long-term unemployment and labour market exclusion of disadvantaged and vulnerable groups by generating new employer-led solutions. The project expects to create, with employers, successful strategies for recruiting disadvantaged workers into better quality jobs, and to co-produce best practice employer engagement toolkits and minimum job quality standards. Anticipated outcomes include increasi ....Creating sustainable employment for disadvantaged and vulnerable groups . This project aims to address long-term unemployment and labour market exclusion of disadvantaged and vulnerable groups by generating new employer-led solutions. The project expects to create, with employers, successful strategies for recruiting disadvantaged workers into better quality jobs, and to co-produce best practice employer engagement toolkits and minimum job quality standards. Anticipated outcomes include increasing the success of government-funded employment programs by improving employment opportunities and reducing cycling between work and welfare. Significant benefits for disadvantaged groups, businesses and society will result in increased employee wellbeing, organisational performance and economic competitiveness.Read moreRead less