New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tack ....New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tackles this problem through a combination of organic and inorganic synthesis to develop new electrochromic dyes that may be attached to mesoporous titania.Read moreRead less
Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. ....Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. Using the combined expertise of the applicants, it is proposed to stereospecifically synthesise dinuclear complexes and study their DNA binding. This will greatly assist in the development of drugs that can selectively target genes and altered DNA.Read moreRead less
Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy ....Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy (the pyridine-2-carboxaldehyde isonicotinoyl hydrazone [PCIH] analogues) which show oral activity. These chelators undergo some interesting iron catalysed oxidation chemistry and it is vital that the mechanism of this reaction be elucidated to determine whether it will be of biological significance upon administration of these compounds as iron chelators.Read moreRead less
Creating sustainable employment for disadvantaged and vulnerable groups . This project aims to address long-term unemployment and labour market exclusion of disadvantaged and vulnerable groups by generating new employer-led solutions. The project expects to create, with employers, successful strategies for recruiting disadvantaged workers into better quality jobs, and to co-produce best practice employer engagement toolkits and minimum job quality standards. Anticipated outcomes include increasi ....Creating sustainable employment for disadvantaged and vulnerable groups . This project aims to address long-term unemployment and labour market exclusion of disadvantaged and vulnerable groups by generating new employer-led solutions. The project expects to create, with employers, successful strategies for recruiting disadvantaged workers into better quality jobs, and to co-produce best practice employer engagement toolkits and minimum job quality standards. Anticipated outcomes include increasing the success of government-funded employment programs by improving employment opportunities and reducing cycling between work and welfare. Significant benefits for disadvantaged groups, businesses and society will result in increased employee wellbeing, organisational performance and economic competitiveness.Read moreRead less
Triumphing in a new Indigenous Australia. A new generation of professionals is triumphing in a new Indigenous Australia. There is a paucity of research that has explained the drivers of this success that has enabled these Indigenous Australians to lead productive and fulfilling lives. Hence little is known about how to replicate this success. This research aims to identify the psycho-social determinants of Indigenous professionals' socio-economic wellbeing. The expected outcomes will include new ....Triumphing in a new Indigenous Australia. A new generation of professionals is triumphing in a new Indigenous Australia. There is a paucity of research that has explained the drivers of this success that has enabled these Indigenous Australians to lead productive and fulfilling lives. Hence little is known about how to replicate this success. This research aims to identify the psycho-social determinants of Indigenous professionals' socio-economic wellbeing. The expected outcomes will include new research-derived strategies for enhancing Indigenous Australians socio-economic wellbeing thus improving Australia's productivity, economic growth, and socio-economic wellbeing while advancing international Indigenous theory, research, and practice and building research capability of Indigenous researchers.Read moreRead less
Developing interdisciplinary expertise in universities. This project aims to create a strong integrative research foundation to explain how university researchers and students develop the expertise needed to work in interdisciplinary teams and how this development can be enhanced. It combines three perspectives investigating: how research and innovation communities create interdisciplinary knowledge, how interdisciplinary teams learn to function effectively and the personal resourcefulness that ....Developing interdisciplinary expertise in universities. This project aims to create a strong integrative research foundation to explain how university researchers and students develop the expertise needed to work in interdisciplinary teams and how this development can be enhanced. It combines three perspectives investigating: how research and innovation communities create interdisciplinary knowledge, how interdisciplinary teams learn to function effectively and the personal resourcefulness that enables individuals to participate in interdisciplinary work. The outcomes will provide a much better understanding of the qualities that help individuals and groups to work productively across disciplinary boundaries. They will be used to create better strategies for supporting interdisciplinary learningRead moreRead less
Light driven supramolecular reactors. A major problem facing synthetic chemistry is how to control chemical reactivity using benign techniques. The aim of this project is to form supramolecular capsules that can bind guest molecules and use visible light to drive chemical reactions inside these cages. This project aims to develop the first examples of molecular cages that are able to catalyse photoredox processes. These enantiopure, self-assembled cages will be based on ruthenium(II) complexes w ....Light driven supramolecular reactors. A major problem facing synthetic chemistry is how to control chemical reactivity using benign techniques. The aim of this project is to form supramolecular capsules that can bind guest molecules and use visible light to drive chemical reactions inside these cages. This project aims to develop the first examples of molecular cages that are able to catalyse photoredox processes. These enantiopure, self-assembled cages will be based on ruthenium(II) complexes with established photophysical properties. The expected outcomes will include the first proof-of-principle examples of controlled photoredox reactions, opening the door for the development of enantioselective molecular photoreactors.Read moreRead less
Metal complexes for sustainable light-driven synthesis. The aim of this project is to use cheap, abundant transition metal ions and visible light to enable challenging synthetic chemical reactions. The significant problems addressed are that most synthetic reactions using visible light currently require expensive precious metals, and fundamental reaction pathways used by Nature remain inaccessible. Both of these problems limit the scope of synthetic applications. The outcomes will be new knowled ....Metal complexes for sustainable light-driven synthesis. The aim of this project is to use cheap, abundant transition metal ions and visible light to enable challenging synthetic chemical reactions. The significant problems addressed are that most synthetic reactions using visible light currently require expensive precious metals, and fundamental reaction pathways used by Nature remain inaccessible. Both of these problems limit the scope of synthetic applications. The outcomes will be new knowledge and sustainable technologies that can better harness visible light for useful synthetic chemistry applications. The benefits will be more efficient and cost-effective routes to valuable molecules ubiquitous in everyday life.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346515
Funder
Australian Research Council
Funding Amount
$507,000.00
Summary
Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in ....Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in mixtures. The current proposal is aimed at introducing new technology into the Australian National Beamline Facility that will greatly improve the quality and quantity of experiments that can be performed and extend studies into dilute solutions and protein samples.Read moreRead less
Women in non-traditional careers: a longitudinal study of female professionals in the mining and resources industries. This project is in line with National Research Priority, strengthening Australia's social and economic fabric, which identifies the importance of research on workforce participation. The main aim of this research is to increase the attraction, participation, development and most importantly, retention of qualified female technical staff in the Australian resource industry. Analy ....Women in non-traditional careers: a longitudinal study of female professionals in the mining and resources industries. This project is in line with National Research Priority, strengthening Australia's social and economic fabric, which identifies the importance of research on workforce participation. The main aim of this research is to increase the attraction, participation, development and most importantly, retention of qualified female technical staff in the Australian resource industry. Analysis of project outputs will directly inform policies and practices to redress the significant skill shortages in the industry. Furthermore enhancing workplace diversity is necessary to create effective and innovative workplaces that reflect the diversity of the broader Australian society.Read moreRead less