Production and application of novel diagnostic and therapeutic reagents using transgenic mice. The project will be a collaboration between the University of Queensland and PanBio Ltd. We intend to use humanized transgenic mice to produce fully human monoclonal antibodies. Fully human antibodies have great advantages over murine antibodies as diagnostics and therapeutics. These reagents will be used to 1)replace human sera , 2)replace antigens from infectious organisms in a range of diagnostic ....Production and application of novel diagnostic and therapeutic reagents using transgenic mice. The project will be a collaboration between the University of Queensland and PanBio Ltd. We intend to use humanized transgenic mice to produce fully human monoclonal antibodies. Fully human antibodies have great advantages over murine antibodies as diagnostics and therapeutics. These reagents will be used to 1)replace human sera , 2)replace antigens from infectious organisms in a range of diagnostic kits for animal and human infectious disease and 3) as therapeutic leads and 4)to discover vaccine leads. The project will allow production of diagnostic kits where this was previously not feasible or not economically viable (eg. uncommon and/or dangerous animal or human diseases) and will lead to development of novel infectious disease diagnostics and therapeutics.Read moreRead less
Microgenomics - a tool to dissect effects of salinity on gene expression in specific cell types of Arabidopsis and rice. This project will provide novel, fundamental understanding of the cell type-specific processes involved in salinity tolerance in higher plants. As such, it will impact on our understanding of a range of processes relevant to salinity tolerance, an area of great importance to Australian agriculture and environmental sustainability. The increased understanding arising from this ....Microgenomics - a tool to dissect effects of salinity on gene expression in specific cell types of Arabidopsis and rice. This project will provide novel, fundamental understanding of the cell type-specific processes involved in salinity tolerance in higher plants. As such, it will impact on our understanding of a range of processes relevant to salinity tolerance, an area of great importance to Australian agriculture and environmental sustainability. The increased understanding arising from this project will underpin future work to increase agricultural productivity and the quality of life for all in the Australian and international communities.Read moreRead less
Development of symbiont based approaches to pest and disease control in sugarcane. This project aims to develop a new approach to the control of insect damage to sugarcane in Australia. It focuses on the manipulation of bacteria that are intimately associated with insects that feed on sugarcane, so as to decrease their ability to cause crop damage both directly through feeding and indirectly through the transmission of disease
Calcium compartmentation in leaves: testing an integrated model of water and calcium transport with cell specific functional genomics. Calcium is a vital nutrient to animals and humans and its storage in vegetation is important for its accessibility. We believe this storage is linked to water flow in the leaf by a novel mechanism. This project will provide fundamental understanding of the cell type-specific processes involved in calcium storage and water flow in plants. High calibre PhD and Hono ....Calcium compartmentation in leaves: testing an integrated model of water and calcium transport with cell specific functional genomics. Calcium is a vital nutrient to animals and humans and its storage in vegetation is important for its accessibility. We believe this storage is linked to water flow in the leaf by a novel mechanism. This project will provide fundamental understanding of the cell type-specific processes involved in calcium storage and water flow in plants. High calibre PhD and Honours students will be educated to maintain the momentum of international excellence within Australia in the field of plant nutrient relations. The increase in understanding will allow future work to improve calcium availability and water use by plants to the benefit of agricultural productivity and quality of life.Read moreRead less
Characterisation of PQ loop proteins in plants: are they voltage insensitive nonselective cation channels? Millions of hectares of Australian agricultural land are affected by salinity. This results in the loss of hundreds of millions of dollars in revenue each year. The identification of the pathway for the initial influx of Na+ into plants from the soil will be important in helping to develop crop plants that are salt tolerant. This will increase our understanding of the mechanisms of salinity ....Characterisation of PQ loop proteins in plants: are they voltage insensitive nonselective cation channels? Millions of hectares of Australian agricultural land are affected by salinity. This results in the loss of hundreds of millions of dollars in revenue each year. The identification of the pathway for the initial influx of Na+ into plants from the soil will be important in helping to develop crop plants that are salt tolerant. This will increase our understanding of the mechanisms of salinity tolerance, an area of great importance to Australian agriculture and environmental sustainability. The future applications of this work will increase agricultural productivity and enhance the quality of life for both Australians and the international community.Read moreRead less
Fungal Glucanase Genes for Engineering Disease Resistance in Plants. Plants can be engineered for resistance to fungal diseases by transformation with recombinant genes encoding chitinase or glucanase. Although fungi are prolific producers of glucanases, with some species producing novel forms, they have been unexplored as a source of useful glucanases. This project will isolate glucanase-producing fungi from soil, screen them for antifungal activity, and clone the glucanase genes from one or m ....Fungal Glucanase Genes for Engineering Disease Resistance in Plants. Plants can be engineered for resistance to fungal diseases by transformation with recombinant genes encoding chitinase or glucanase. Although fungi are prolific producers of glucanases, with some species producing novel forms, they have been unexplored as a source of useful glucanases. This project will isolate glucanase-producing fungi from soil, screen them for antifungal activity, and clone the glucanase genes from one or more isolates. In view of the high degree of biodiversity in WA soils, we have a high expectation of finding novel glucanases which will be useful for engineering disease resistance in plants, or for other industrial processes.Read moreRead less
Using integrated frontier and smart technologies to identify new drug targets for parasites causing major diseases in humans and animals. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of anti-parasite compounds and/or vaccines; (2) improved and sustainable control of important parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a ....Using integrated frontier and smart technologies to identify new drug targets for parasites causing major diseases in humans and animals. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of anti-parasite compounds and/or vaccines; (2) improved and sustainable control of important parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a technology platform for further applications in genomics and post-genomics of pathogens of global significance and construction of a pipeline for the validation of drug targets; (5) capturing the benefits from fundamental research and strengthening links between fundamental and applied research; (6) increasing the quality and quantity of scientifically skilled people in biotechnology.Read moreRead less
Automated, smart genomic data integration for the exploration of developmentally regulated molecules in parasites of major socioeconomic importance. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of safe anti-parasite compounds/vaccines; (2) improved and sustainable control of key parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation o ....Automated, smart genomic data integration for the exploration of developmentally regulated molecules in parasites of major socioeconomic importance. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of safe anti-parasite compounds/vaccines; (2) improved and sustainable control of key parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a technology platform for further applications in genomics and post-genomics of pathogens of global significance and construction of a pipeline for the validation of drug targets; (5) capturing the benefits from fundamental research and strengthening links between fundamental and applied research; (6) increasing the quality and quantity of scientifically skilled people in biotechnology.Read moreRead less
Embryo genomics for engineering change. The proposed research program will contribute to areas that are critically important for Australia, such as agriculture, animal biodiversity, biomedicine, human health and biosafety. By addressing the high economic losses due to early embryonic mortality in farm animals, results from this research will enhance the competitiveness of Australian agriculture and biomedical research. The establishment of a world class research Centre for Animal Biotechnology a ....Embryo genomics for engineering change. The proposed research program will contribute to areas that are critically important for Australia, such as agriculture, animal biodiversity, biomedicine, human health and biosafety. By addressing the high economic losses due to early embryonic mortality in farm animals, results from this research will enhance the competitiveness of Australian agriculture and biomedical research. The establishment of a world class research Centre for Animal Biotechnology at the University of Adelaide will create a major addition to the national research base. The Centre will develop technology platforms to support various groups across the entire Australian scientific community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668450
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Upgrade of comparative phenotypical and functional cell analysis at James Cook University. North Queensland is a fast growing region with significant need for the development of a world-class research facility. James Cook University has recently established the Comparative Genomics Centre at the School of Pharmacy and Molecular Sciences, which will contribute to education and basic research in the region. The research outcomes from the projects of the Comparative Genomics Centre and affiliated l ....Upgrade of comparative phenotypical and functional cell analysis at James Cook University. North Queensland is a fast growing region with significant need for the development of a world-class research facility. James Cook University has recently established the Comparative Genomics Centre at the School of Pharmacy and Molecular Sciences, which will contribute to education and basic research in the region. The research outcomes from the projects of the Comparative Genomics Centre and affiliated laboratories facilitated by the analytical flow cytometer will support the definition and identification of the interactions between genetic and environmental factors in disease and will help to attract researchers. Results from this work will aid the search for therapies for specific health problems.Read moreRead less