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THE EFFECTS OF TRANSCRANIAL MAGNETIC STIMULATION (TMS) ON RAT MODELS OF DEPRESSION
Funder
National Health and Medical Research Council
Funding Amount
$204,274.00
Summary
Repetitive Transcranial Magnetic Stimulation (rTMS) is the direct stimulation of the brain by using high field magnetic pulses. It is a new technique that has been demonstrated to have some potential as a treatment of depressive illness and possibly other neuropsychiatric disorders. At this early stage of its investigation, the parameters of stimulation that are most likely to be therapeutic, and its mechanisms of action, are not known. Published studies vary in the frequency, duration and exten ....Repetitive Transcranial Magnetic Stimulation (rTMS) is the direct stimulation of the brain by using high field magnetic pulses. It is a new technique that has been demonstrated to have some potential as a treatment of depressive illness and possibly other neuropsychiatric disorders. At this early stage of its investigation, the parameters of stimulation that are most likely to be therapeutic, and its mechanisms of action, are not known. Published studies vary in the frequency, duration and extent of stimulation, with no firm guidelines about optimal parameters. Empirical study of the relative effects of stimulation at different frequencies, at different numbers of stimuli and for different durations is therefore important for the future development of this treatment. Such an investigation is best carried out in an animal model of depression for both ethical and practical reasons, as such studies in patients would possibly take many years and be extremely difficult to conduct. We propose such a study in rat models of depression which have demonstrated validity and utility in drug research. Rat models have a long track record in developing psychiatric treatments and are cost-effective and of proven value. We also plan to investigate the neuroanatomy of the immediate-early genes induced by TMS and compare it with electroconvulsive shock (ECS) and a tricyclic antidepressant, two established treatments of depression. The results will have implications for future human studies in guiding us toward the optimal parameters for therapeutic effects. They will also enhance our understanding of the mechanism of action of TMS in depression.Read moreRead less
Application Of Intelligent Conducting Polymers For Treating Schizophrenia And Allied Disorders Focusing On Neuronal Outgrowth, Myelination And Synaptogenesis
Funder
National Health and Medical Research Council
Funding Amount
$698,314.00
Summary
This project involves cross-disciplinary collaboration between researchers at the forefront of materials engineering, nanotechnology, neural pathology, human stem cell biology and mental health disciplines. We will use a nanodevice to apply electrical stimuli and growth factors to improve brain function in schizophrenia and allied disorders.
A Selective Prevention Trial Using Novel Pharmacotherapies In An Older Age Cohort At Risk For Depression
Funder
National Health and Medical Research Council
Funding Amount
$975,259.00
Summary
The study will examine whether omega-3 fatty acids or antidepressants prevent the onset of depression in a group of older community participants who have previously been identified as being "at risk" of depression. The study will incorporate sophisticated brain scanning methods, as well as tests of brain functioning to determine acute brain changes, reduction in cognitive decline and prevention of depression over a one-year period.
A Randomised Controlled Trial Of Low-dose Ketamine In Youth With Severe Depression And Elevated Suicide Risk
Funder
National Health and Medical Research Council
Funding Amount
$2,232,757.00
Summary
Recent research has shown that a single injection of low-dose ketamine has powerful, though short-lived, antidepressant effects. Effective treatments are urgently needed for young people with severe depression. This will be the first controlled study to test whether repeated doses of ketamine, given over 4 weeks, is effective for young patients.
The Burden Of Late Preterm Birth On Brain Development And 2 Year Outcomes – A Prospective, Longitudinal Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$838,690.00
Summary
80% of preterm babies are born from 32-36 weeks’ gestation, and are late preterm (LPT). LPT children have more learning problems, but why this occurs is unknown. This study aims to understand the effect of LPT birth on brain development. We will do brain scans at term and assess development at 2 years of age of 200 LPT and 200 full-term children. We expect LPT babies will have subtle alterations in brain development compared with term controls which will be associated with delayed development.
Centre Of Research Excellence (CRE) In Newborn Medicine
Funder
National Health and Medical Research Council
Funding Amount
$2,622,320.00
Summary
Problems around birth are common and can have long-term implications, including into adulthood. Our goal is to improve health outcomes for all newborn babies and their families by determining factors that enhance outcome and assessing the benefits and consequences of new treatments for mothers and babies. We are world leaders in this field and are dedicated to training the next generation of health professionals in the care of newborn babies, in Australia and the rest of the world.
Design and Creation of Nanomechanical Architectures from Folding of Ultrathin Bi-layer Films. The project will achieve progress in designing, modelling, analyzing, and characterization of nanomechanical architectures that will have broad application in Australian science and industry. If successful, our research will revolutionize nanofabrication technology and nano-design methods. The project will lead to a scientific understanding of atomic interaction and stress field effect in the formation ....Design and Creation of Nanomechanical Architectures from Folding of Ultrathin Bi-layer Films. The project will achieve progress in designing, modelling, analyzing, and characterization of nanomechanical architectures that will have broad application in Australian science and industry. If successful, our research will revolutionize nanofabrication technology and nano-design methods. The project will lead to a scientific understanding of atomic interaction and stress field effect in the formation of nanosystems. The result of this research will significantly lower fabrication costs and enhance the potential of nanomaterials in various areas such as electronics and bioelectronics, telecommunication, medical instrumentations, and pharmaceutical design. Read moreRead less
An FMRI Analysis Of The Functional Organization Within The Brain Of Experimental Superficial And Deep Orofacial Pain
Funder
National Health and Medical Research Council
Funding Amount
$307,526.00
Summary
This project will investigate how the human brain processes a number of important aspects of human jaw muscle pain that are clinically relevant but poorly understood. For example, we do not understand why jaw muscle pain has such different behavioural effects to skin pain. Jaw muscle pain is associated with a significant emotional component not seen in with skin pains. Also, skin pain usually has a sharp or burning quality, is well-localized and is readily treated, while jaw muscle pain is a dee ....This project will investigate how the human brain processes a number of important aspects of human jaw muscle pain that are clinically relevant but poorly understood. For example, we do not understand why jaw muscle pain has such different behavioural effects to skin pain. Jaw muscle pain is associated with a significant emotional component not seen in with skin pains. Also, skin pain usually has a sharp or burning quality, is well-localized and is readily treated, while jaw muscle pain is a deep pain that has a dull, aching quality that may be referred to related sites of the face, head and neck. It is also not known why jaw muscle pain is more common in females in comparison to males. Chronic jaw muscle pain is a major symptom of patients with Temporomandibular Disorders, the most common form of non-dental orofacial pain and that involves pain in or about the jaw joint and-or jaw muscles, and often limitation of jaw movement. Chronic jaw muscle pain can have a severe effect on quality of life but its diagnosis and management is difficult. Despite the widespread prevalence of chronic orofacial pains, we have little information on the central processing of chronic human orofacial pain. This proposal will improve our fundamental understanding of how jaw muscle pain is processed in the brain. The way that the central nervous system processes and represents jaw muscle pain will help explain why these pains present differently in the clinic and should provide important information on the differences between females and males in the representation of jaw muscle pain. This information on the central processing of chronic orofacial pain is crucial to inform the direction of novel or specific management strategies. Our long-term goal is to improve the diagnosis and management of patients with Temporomandibular Disorders, and the present application represents a major new direction of research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237874
Funder
Australian Research Council
Funding Amount
$424,000.00
Summary
Active Polymer Research Facility. Sustainable economic growth for Australia requires renewable, environmentally acceptable energy resources. Solar cells made from conducting polymers present the tantalising possibility of producing cheap electricity from sunlight. Future development of these devices depends critically upon ready access to the advanced equipment necessary to investigate their material, device and photovoltaic characteristics. This project aims to establish the first integrated ch ....Active Polymer Research Facility. Sustainable economic growth for Australia requires renewable, environmentally acceptable energy resources. Solar cells made from conducting polymers present the tantalising possibility of producing cheap electricity from sunlight. Future development of these devices depends critically upon ready access to the advanced equipment necessary to investigate their material, device and photovoltaic characteristics. This project aims to establish the first integrated characterisation facility in Australia dedicated to developing efficient polymer solar cells. The Active Polymer Research Facility will allow researchers from Newcastle, Wollongong and Massey University to maintain their position at the forefront of international research into polymer photovoltaic devices.Read moreRead less
Plastic Solar Cells: Polymers that Harvest Sunlight. Sustainable economic growth for Australia requires renewable, environmentally acceptable energy resources. The most attractive option for the future generation of electrical energy is via the direct conversion of sunlight. The utilisation of solar energy has significant advantages over other energy sources in that it is inexhaustible and does not produce carbon dioxide or other pollutants. Conventional photovoltaic technology is not cost effe ....Plastic Solar Cells: Polymers that Harvest Sunlight. Sustainable economic growth for Australia requires renewable, environmentally acceptable energy resources. The most attractive option for the future generation of electrical energy is via the direct conversion of sunlight. The utilisation of solar energy has significant advantages over other energy sources in that it is inexhaustible and does not produce carbon dioxide or other pollutants. Conventional photovoltaic technology is not cost effective. Solar cells made from conducting polymers present the tantalising possibility of producing cheap electricity from sunlight. This project brings together experts in the physics and chemistry of conducting polymers with the goal of developing efficient plastic solar cells.Read moreRead less