Discovering New Pathways To Improved Biotherapeutic Treatment Of Snakebite Envenoming.
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Snakebite is a public health emergency affecting up to 5.4 million people a year, causing up to 125,000 deaths. This multidisciplinary project will develop a new generation of medicines for treating snakebites, using innovative design approaches supported by cutting edge science and novel production ideas. Directly focused on improving antivenom effectiveness in the treatment of snakebites in Australia, Africa and Papua New Guinea, the results will make Australia a world leader in this field.
Peptide Toxins From Animal Venoms Specifically Targeting Voltage-gated Sodium Channels As Novel Analgesics And Pesticides
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
This project aims to understand how certain animal toxins that cause analgesic and pesticidal effects in model animals interact with biological ion channels in atomistic detail using computational techniques. By understanding the detailed molecular interactions involved in the binding of the toxins to channels, toxin variants with improved potency and specificity may be designed as promising templates for novel analgesics and pesticides.