Pharmacological Characterisation Of Venoms From Australian Box Jellyfish
Funder
National Health and Medical Research Council
Funding Amount
$33,626.00
Summary
Australian box jellyfish are responsible for many stings in Australia every year. Years of scientific research have gone into studying how these venoms work however, their mechanism of action is still unknown. Most of these venoms cause cardiovascular effects in envenomed people. Our aim is to isolate and characterise these toxins in the venoms, this will hopefully allow us to then isolate their mechanism of action. Thus allowing for better management of accidental human envenomings.
A Randomised Controlled Trial Of Factor Replacement Therapy In Snake Bite Coagulopathy
Funder
National Health and Medical Research Council
Funding Amount
$715,730.00
Summary
This proposal seeks funding to undertake a controlled trial of clotting factor replacement in snake bite coagulopathy after the administration of a neutralising dose of antivenom. The aim is to determine if factor replacement will result in a rapid return of clotting function in patients and therefore reduce the potential risk of major bleeding. This study will have international implications because globally snakebite coagulopathy is a major cause of morbidity and death like in Australia.
Randomised Controlled Trial Of Intravenous Antivenom Versus Placebo In The Treatment Of Redback Spider Bite
Funder
National Health and Medical Research Council
Funding Amount
$487,440.00
Summary
Redback spiderbite is the most common significant envenoming in Australia and bites by the closely related widow spiders are a major global problem. Despite widespread use of redback spider antivenom, no controlled study has tested its effectiveness. This study aims to test the efficacy of antivenom versus placebo in a large multicentre, randomised controlled trial - RAVE-II. It is of critical importance to determine if an expensive treatment with a known risk of allergic reactions is effective.