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Dissecting BAFF Receptor Signals: Key Mediators Of B-Lymphocyte Survival And Autoimmune Disease
Funder
National Health and Medical Research Council
Funding Amount
$376,165.00
Summary
B-Cells of the immune system need a growth factor named 'BAFF' to grow and survive. Elevated levels of BAFF have been detected in patients suffering from autoimmune diseases like lupus and arthritis, and B-Cell cancers like myeloma. This study will determine the identity of the chemical messages that BAFF sends to B-Cells, and how these facilitate B-Cell growth and survival. This will provide a framework for the design of targeted drug therapies that reduce the severity of BAFF related diseases.
Regulation Of Antiviral And Antiinflammatory Responses By MTNF: Key Role Of Reverse Signaling By Host And Viral TNFR
Funder
National Health and Medical Research Council
Funding Amount
$568,501.00
Summary
New and re-emerging viral infections continue to pose a major problem. We have recently discovered a hitherto unrecognized process that the body uses to regulate its response to infection. Some viruses have evolved to target this process, underscoring its importance. We will study 2 virus models, poxvirus and influenza A, to understand how this process works during infection. We will also examine the potential to exploit this process to block pathology and influence recovery from infection.
A Novel Viral Modifier Of TNF Family Receptor Signalling: Elucidation Of Mechanisms Of Action
Funder
National Health and Medical Research Council
Funding Amount
$453,727.00
Summary
Over millions of years, viruses have evolved a great number of strategies to allow them to subvert the effectiveness of the host response. We have discovered that one of these viral strategies seems designed to block the synthesis of an important anti-viral factor, called tumour necrosis factor. In this project, we aim to work out how the viral factor blocks tumour necrosis factor production inside the cell, at the level of the molecules involved. The second aspect of this project concerns the i ....Over millions of years, viruses have evolved a great number of strategies to allow them to subvert the effectiveness of the host response. We have discovered that one of these viral strategies seems designed to block the synthesis of an important anti-viral factor, called tumour necrosis factor. In this project, we aim to work out how the viral factor blocks tumour necrosis factor production inside the cell, at the level of the molecules involved. The second aspect of this project concerns the identification of the types of cells and responses which the viral factor acts upon to manipulate the host response. We reason that this information will improve our understanding of how tumour necrosis factor production is regulated and the significance of this type of response in virus infection and physiology, more generally. The application of this research will be to aid the design of better drugs for the treatment of many conditions where tumour necrosis factor production contributes significantly to pathology, eg rheumatoid arthritis and autoimmunity. In some conditions, it may be a therapeutic advantage to selectively turn on tumour necrosis factor, eg for treatment of infections or cancer.Read moreRead less