The Role Of Stem-progenitor Cells In Regeneration Of Mouse Endometrium.
Funder
National Health and Medical Research Council
Funding Amount
$311,938.00
Summary
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Central Neural Circuits Subserving Nutrient–activated Thermogenesis - The Basis Of Post Prandial Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$766,207.00
Summary
Studies of “energy burning” brown fat, including its importance in the determination of obesity in humans and the potential to increase its capacity by turning white fat into brown-like fat are currently foremost in obesity research. Here we study the detail of brain pathways that dictate brown fat activity after a meal resulting in the burning of ingested calories and reduction of body weight. The results will give us a better idea of how we can harness brown fat to combat obesity.
ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green che ....ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green chemical industries by utilising abundant sunlight, seawater, and waste feedstocks. This should provide significant benefits, through industry collaborations, our new world-leading capacity will train a next generation of game changers to empower emerging carbon industries to solve grand socio-economic challenges, ultimately meeting zero-carbon emissions targets.Read moreRead less
Hierarchically Structured Graphene-Based Nanoassemblies. Developing high-efficiency, low-cost and environmentally friendly electrochemical energy conversion and storage devices is essential to many consumer electronics. The development of high-performance graphene-based electrode materials in this project will have significant impacts on the Australian economy. This project is expected to help place Australia at the forefront of advanced energy materials and nanotechnology, and enhance the inter ....Hierarchically Structured Graphene-Based Nanoassemblies. Developing high-efficiency, low-cost and environmentally friendly electrochemical energy conversion and storage devices is essential to many consumer electronics. The development of high-performance graphene-based electrode materials in this project will have significant impacts on the Australian economy. This project is expected to help place Australia at the forefront of advanced energy materials and nanotechnology, and enhance the international competitiveness and export power of Australian industry in the high-technology areas. It will also help address the rapidly growing environmental concerns and the increasing global demand for energy.Read moreRead less
Central Neural Regulation Of Brown Fat Function – Glucose Sensing And CNS Pathways
Funder
National Health and Medical Research Council
Funding Amount
$761,942.00
Summary
Our research aims to identify how specific brain cells detect changes in glucose levels and how ageing and diet affect their function. We identified a subset of nerve cells that detect changes in glucose and the “hunger” hormone ghrelin, their ability to do so adapting with age and nutritional status. This project will investigate the potential of these nerve cells as targets for therapeutic and diet- intervention strategies to target obesity, diabetes and promote healthy ageing.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Accurate Context-Aware Search for Managed Document Collections. Search is a key component of a vast range of computing applications. However, while search on large collections of general-purpose text is well-understood, and the best systems are highly effective, search on smaller or special-purpose collections is much less reliable and has attracted relatively little research. By identifying general ways of using context such as user history or prior page usefulness, the quality of search in s ....Accurate Context-Aware Search for Managed Document Collections. Search is a key component of a vast range of computing applications. However, while search on large collections of general-purpose text is well-understood, and the best systems are highly effective, search on smaller or special-purpose collections is much less reliable and has attracted relatively little research. By identifying general ways of using context such as user history or prior page usefulness, the quality of search in such cases can be greatly improved. Products that make use of these principles will provide greater workplace efficiency and be able to locate information that other search tools cannot identify.Read moreRead less
ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. ....ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. photovoltaics, batteries, including wearable systems), and novel energy transfer in bioapplications (eg. Bionic Ear). These advances, together with the resource of trained personnel, will assist Australian industry to exploit this exciting area.Read moreRead less
Improving battery safety with boron nitride nanotube separators. This project aims to improve the safety of lithium ion batteries by developing high –temperature, stable separators. The use of batteries in a hot Australian summer is a major safety issue for our society. This project will develop a new and safe battery technology with the help of boron nitride nanotubes to effectively reduce the risk of thermal runaway of battery cells. The expected outcomes will have a global impact on the safet ....Improving battery safety with boron nitride nanotube separators. This project aims to improve the safety of lithium ion batteries by developing high –temperature, stable separators. The use of batteries in a hot Australian summer is a major safety issue for our society. This project will develop a new and safe battery technology with the help of boron nitride nanotubes to effectively reduce the risk of thermal runaway of battery cells. The expected outcomes will have a global impact on the safety of the current battery technology and the innovative application of boron nitride nanotubes in battery technology. It will position industry on the cutting edge of battery technology required for energy storage development in Australia.Read moreRead less