We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green che ....ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green chemical industries by utilising abundant sunlight, seawater, and waste feedstocks. This should provide significant benefits, through industry collaborations, our new world-leading capacity will train a next generation of game changers to empower emerging carbon industries to solve grand socio-economic challenges, ultimately meeting zero-carbon emissions targets.Read moreRead less
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. ....ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. photovoltaics, batteries, including wearable systems), and novel energy transfer in bioapplications (eg. Bionic Ear). These advances, together with the resource of trained personnel, will assist Australian industry to exploit this exciting area.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH200100035
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub in New Safe and Reliable Energy Storage and Conversion Technologies. This Research Hub addresses safety and reliability issues, and environmental impact of current energy storage and conversion technologies. The research will deliver a new generation of technologies for storage from small scale portable devices to large scale industrial applications, using recycled and natural materials, and eliminating the serious fire risk in current technologies. Outcomes include innovative ....ARC Research Hub in New Safe and Reliable Energy Storage and Conversion Technologies. This Research Hub addresses safety and reliability issues, and environmental impact of current energy storage and conversion technologies. The research will deliver a new generation of technologies for storage from small scale portable devices to large scale industrial applications, using recycled and natural materials, and eliminating the serious fire risk in current technologies. Outcomes include innovative integrated energy conversion and storage technologies and new energy materials and devices designed for different scale applications, leading to creation of start up companies and commercialisation opportunities for existing partners, benefiting both the Australian economy and potentially transforming the energy industry landscape.Read moreRead less
Engineering vanadium oxide-based cathode for aqueous ammonium ion batteries. This project aims to develop the next-generation rechargeable aqueous ammonium ion batteries and the scaled-up prototypes. It will be innovatively powered by nonmetallic charge carriers to show superior safety, low cost, high rate and cycle performance, and large capacity, ensuring realistic implementation for industrial purposes. Expected outcomes include a series of chemically and morphologically tuned vanadium oxide- ....Engineering vanadium oxide-based cathode for aqueous ammonium ion batteries. This project aims to develop the next-generation rechargeable aqueous ammonium ion batteries and the scaled-up prototypes. It will be innovatively powered by nonmetallic charge carriers to show superior safety, low cost, high rate and cycle performance, and large capacity, ensuring realistic implementation for industrial purposes. Expected outcomes include a series of chemically and morphologically tuned vanadium oxide-based cathode materials, a novel and reliable working principle based on reversible ammonium ion storage, and battery pack prototypes targeting industry demanded energy density and lifespan. Via industrial pilot trials, commercial benefits will be fast tracked for clean energy storage, net zero future and industry upgrades.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH180100020
Funder
Australian Research Council
Funding Amount
$3,058,152.00
Summary
ARC Research Hub for Integrated Energy Storage Solutions. The ARC Research Hub for Integrated Energy Storage Solutions aims to develop advanced energy storage technologies, including printed batteries, structural supercapacitors, innovative fuel cells and power-to-gas systems. It plans to integrate these storage solutions with existing energy networks and applications using novel storage monitoring, control and optimisation technologies. The Hub is expected to generate new knowledge in storage t ....ARC Research Hub for Integrated Energy Storage Solutions. The ARC Research Hub for Integrated Energy Storage Solutions aims to develop advanced energy storage technologies, including printed batteries, structural supercapacitors, innovative fuel cells and power-to-gas systems. It plans to integrate these storage solutions with existing energy networks and applications using novel storage monitoring, control and optimisation technologies. The Hub is expected to generate new knowledge in storage technology manufacturing, control and management. Expected outcomes include cheaper and more effective storage devices and better storage integration solutions, supporting renewables, reducing carbon emissions, and improving efficiency in the energy sector. Resulting benefits include a more sustainable, secure, reliable and economically efficient energy supply. This Hub will contribute to improving the economic efficiency of Australia’s energy sector.Read moreRead less
Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hyd ....Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hydrogen atoms around micro-scale features and to compare it to local mechanical behaviour, determined by micro-mechanical tests. The systematic investigation of the effect of hydrogen on different micro-components within steel will allow the development of microstructure-guided alloy design principles.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101105
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
Developing Sustainable and Reliable Anode-free Lithium Metal Batteries. This project aims to investigate and optimise the functional properties of anode-free lithium metal battery electrodes. The project expects to develop a novel, high-throughput electrochemistry platform that can rapidly screen new materials and chemistries across length scales, from single atoms to entire battery cells. Understanding battery performance in such detail is expected to enhance our capability to design and manufa ....Developing Sustainable and Reliable Anode-free Lithium Metal Batteries. This project aims to investigate and optimise the functional properties of anode-free lithium metal battery electrodes. The project expects to develop a novel, high-throughput electrochemistry platform that can rapidly screen new materials and chemistries across length scales, from single atoms to entire battery cells. Understanding battery performance in such detail is expected to enhance our capability to design and manufacture smart battery materials that are higher performing, safer and longer lasting than current technologies. This should provide significant socio-economic and environmental benefits, through the development of commercially-feasible next-generation devices, used by households or businesses to store renewable energy.Read moreRead less
Defining and developing a marine cadastre for Australia. Australia's ocean territories cover an area 1.5 times larger than the nation's land mass. Systems for the management and administration of land in a spatial context have been developed over many years but no such system exists for the nation's oceans. A marine cadastre aims at providing a comprehensive spatial data infrastructure and spatial analysis tools for the assessment, administration and management of rights, restrictions and respo ....Defining and developing a marine cadastre for Australia. Australia's ocean territories cover an area 1.5 times larger than the nation's land mass. Systems for the management and administration of land in a spatial context have been developed over many years but no such system exists for the nation's oceans. A marine cadastre aims at providing a comprehensive spatial data infrastructure and spatial analysis tools for the assessment, administration and management of rights, restrictions and responsibilities in the marine environment. The objective of this project is to investigate the issues and define the problems associated with the development of a marine cadastre, thereby providing the foundation for future research.Read moreRead less