Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Novel nanostructured high energy cathode material. Recently, the demand for rechargeable batteries has exploded due to the enormous increase in the variety and number of miniaturized devices. It is expected that this demand for high capacity rechargeable batteries as energy sources will become even greater in the future. This program is focused to develop novel high performance cathode materials for lithium rechargeable batteries. The outcomes of the project will be of great benefit to develop ....Novel nanostructured high energy cathode material. Recently, the demand for rechargeable batteries has exploded due to the enormous increase in the variety and number of miniaturized devices. It is expected that this demand for high capacity rechargeable batteries as energy sources will become even greater in the future. This program is focused to develop novel high performance cathode materials for lithium rechargeable batteries. The outcomes of the project will be of great benefit to develop new class rechargeable batteries that are economical, lightweight, environmentlly benign and high energy.Read moreRead less
ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green che ....ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green chemical industries by utilising abundant sunlight, seawater, and waste feedstocks. This should provide significant benefits, through industry collaborations, our new world-leading capacity will train a next generation of game changers to empower emerging carbon industries to solve grand socio-economic challenges, ultimately meeting zero-carbon emissions targets.Read moreRead less
Advanced Nanostructured Ceramic Composites for Ultracapacitors. The global climate changes and the related disastrous events such as heat flows, bushfires, and flooding will endanger the Australian population and our natural environment. The implementation of effective devices and technologies to reduce our carbon footprint is a priority task. The project addresses the issue by development of new ultracapacitor materials for next generation green energy storage devices through engineering and im ....Advanced Nanostructured Ceramic Composites for Ultracapacitors. The global climate changes and the related disastrous events such as heat flows, bushfires, and flooding will endanger the Australian population and our natural environment. The implementation of effective devices and technologies to reduce our carbon footprint is a priority task. The project addresses the issue by development of new ultracapacitor materials for next generation green energy storage devices through engineering and implementation of advanced nanoceramics and nanocomposites created by innovative nanotechnologies. The project will also contribute to other national research priorities such as materials and frontier technologies, reduction of atmospheric pollution, and decrease in the energy dependence of our country on oil.Read moreRead less
Developing lithium metal batteries – a game-changer for renewable energy. This project aims to develop nanostructured lithium metal anodes for rechargeable lithium metal batteries with high energy density and excellent cycle life. Lithium metal batteries such as lithium-sulfur batteries and lithium carbon-dioxide batteries present great opportunities for long-range electric vehicles and high-efficient renewable energy storage. Through the rational structure design and advanced interface engineer ....Developing lithium metal batteries – a game-changer for renewable energy. This project aims to develop nanostructured lithium metal anodes for rechargeable lithium metal batteries with high energy density and excellent cycle life. Lithium metal batteries such as lithium-sulfur batteries and lithium carbon-dioxide batteries present great opportunities for long-range electric vehicles and high-efficient renewable energy storage. Through the rational structure design and advanced interface engineering, the developed lithium metal anodes are expected to overcome the critical issues that hindered their practical application for high-energy batteries. The success of this project will provide new technological solutions for next-generation energy storage devices.Read moreRead less
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Special Research Initiatives - Grant ID: SR0354535
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Advanced Electromaterials from Nanomaterials and Biomaterials. The proposed initiative brings together relevant sectors of the nanomaterials, biomaterials and electrochemistry research communities. It is envisaged that the collective complementary expertise will give rise to research opportunities and insights into the emerging work of electro-bio-nano. Scientific and technological challenges that exist in this multidiscipline research space include areas as diverse as the development of more ....Advanced Electromaterials from Nanomaterials and Biomaterials. The proposed initiative brings together relevant sectors of the nanomaterials, biomaterials and electrochemistry research communities. It is envisaged that the collective complementary expertise will give rise to research opportunities and insights into the emerging work of electro-bio-nano. Scientific and technological challenges that exist in this multidiscipline research space include areas as diverse as the development of more efficient nerve cell communication implants, understanding and control of biocorrosion/biofouling and the use of biomimicry to produce more efficient catalysts and artificial muscles.Read moreRead less
ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. ....ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. photovoltaics, batteries, including wearable systems), and novel energy transfer in bioapplications (eg. Bionic Ear). These advances, together with the resource of trained personnel, will assist Australian industry to exploit this exciting area.Read moreRead less
Design and Synthesis of Ionic Liquids for Use in Photoelectrochemical Cells Based on Inherently Conducting Polymers. We propose to evaluate the electrochemistry of photoactive polythiophenes recently synthesised by us in a range of ionic liquids. This knowledge will be used to design and synthesise customised ionic liquids with the properties required to enhance the photoelectrochemical efficiency of devices based on substituted polythiophenes. We expect our findings to lead to the development ....Design and Synthesis of Ionic Liquids for Use in Photoelectrochemical Cells Based on Inherently Conducting Polymers. We propose to evaluate the electrochemistry of photoactive polythiophenes recently synthesised by us in a range of ionic liquids. This knowledge will be used to design and synthesise customised ionic liquids with the properties required to enhance the photoelectrochemical efficiency of devices based on substituted polythiophenes. We expect our findings to lead to the development of low-cost, flexible, organic photoelectrochemical cells.Read moreRead less