We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green che ....ARC Centre of Excellence for Carbon Science and Innovation. ARC Centre of Excellence for Carbon Science and Innovation. This Centre aims to develop carbon-based catalysts for clean energy, CO2 capture, and green chemistry to reduce emissions. The Centre expects to use pioneering data-guided atomic-precision synthesis and multiscale analysis to transform fundamental science of carbon materials. Expected outcomes of this Centre will benefit new technologies for energy, environmental, and green chemical industries by utilising abundant sunlight, seawater, and waste feedstocks. This should provide significant benefits, through industry collaborations, our new world-leading capacity will train a next generation of game changers to empower emerging carbon industries to solve grand socio-economic challenges, ultimately meeting zero-carbon emissions targets.Read moreRead less
ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. ....ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. photovoltaics, batteries, including wearable systems), and novel energy transfer in bioapplications (eg. Bionic Ear). These advances, together with the resource of trained personnel, will assist Australian industry to exploit this exciting area.Read moreRead less
Making hydrogen storage work for the new hydrogen economy. This project aims to develop an innovative Liquid Organic Hydrogen Storage technology and prove its energy industry potential. This project expects to expand and validate the performance, safety and scale-up potential of this new technology in an industrial context to promote the development of the hydrogen economy. Expected outcomes include providing practical, efficient, large-scale storage technology for use in intermittent renewable ....Making hydrogen storage work for the new hydrogen economy. This project aims to develop an innovative Liquid Organic Hydrogen Storage technology and prove its energy industry potential. This project expects to expand and validate the performance, safety and scale-up potential of this new technology in an industrial context to promote the development of the hydrogen economy. Expected outcomes include providing practical, efficient, large-scale storage technology for use in intermittent renewable energy storage and hydrogen vehicle refuelling, and addressing legal/regulatory implementation issues. This should provide significant benefits in cultivating the emerging hydrogen energy industry, strengthening industrial competitiveness, enhancing Australia’s fuel security and protecting the environment.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH180100020
Funder
Australian Research Council
Funding Amount
$3,058,152.00
Summary
ARC Research Hub for Integrated Energy Storage Solutions. The ARC Research Hub for Integrated Energy Storage Solutions aims to develop advanced energy storage technologies, including printed batteries, structural supercapacitors, innovative fuel cells and power-to-gas systems. It plans to integrate these storage solutions with existing energy networks and applications using novel storage monitoring, control and optimisation technologies. The Hub is expected to generate new knowledge in storage t ....ARC Research Hub for Integrated Energy Storage Solutions. The ARC Research Hub for Integrated Energy Storage Solutions aims to develop advanced energy storage technologies, including printed batteries, structural supercapacitors, innovative fuel cells and power-to-gas systems. It plans to integrate these storage solutions with existing energy networks and applications using novel storage monitoring, control and optimisation technologies. The Hub is expected to generate new knowledge in storage technology manufacturing, control and management. Expected outcomes include cheaper and more effective storage devices and better storage integration solutions, supporting renewables, reducing carbon emissions, and improving efficiency in the energy sector. Resulting benefits include a more sustainable, secure, reliable and economically efficient energy supply. This Hub will contribute to improving the economic efficiency of Australia’s energy sector.Read moreRead less
Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans ....Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans to address the challenge of sodium stability in highly irradiated tubes by investigating mass, momentum, energy and radiative transport in liquid metals. It is intended that this will inform the design and testing of novel sodium boilers to provide stable and isothermal process heat for continuous or on-demand production of power, chemical fuels and commodities.Read moreRead less
Multifunctional trilayer separator for durable multivalent energy storage. This project aims to develop an important new family of economical, high energy, multivalent batteries based on an abundant element, sulphur. The project plans to design a new battery separator to enable long-term stability in sulphur-based rechargeable batteries. This type of separator is of critical importance in many membrane-involved energy storage technologies. The project plans to use leading-edge durable energy tec ....Multifunctional trilayer separator for durable multivalent energy storage. This project aims to develop an important new family of economical, high energy, multivalent batteries based on an abundant element, sulphur. The project plans to design a new battery separator to enable long-term stability in sulphur-based rechargeable batteries. This type of separator is of critical importance in many membrane-involved energy storage technologies. The project plans to use leading-edge durable energy technologies to strengthen the development of residential energy systems and the involvement of renewable energy sources in modern grid.Read moreRead less
Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive econom ....Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive economic opportunity. However, the high flammability and low ignition energy of hydrogen makes it vulnerable to accidental explosions. Hence, this project will address the lack of safety protocols in Australian Standards related to the handling of hydrogen by producing essential design recommendations.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101113
Funder
Australian Research Council
Funding Amount
$428,000.00
Summary
Optimal reaction pathways towards advanced energy technology. This project aims to develop a novel lithium-ion battery (LIB) system that delivers high energy-density, a long cycle life, low-cost, and high safety based on conversion-type lithium oxide cathodes. Expected outcomes of this project will address the preliminary challenges for the practical use of lithium-oxide, which requires innovative designs of reaction pathways to lithium oxide cathode and lithium metal anode architectures as well ....Optimal reaction pathways towards advanced energy technology. This project aims to develop a novel lithium-ion battery (LIB) system that delivers high energy-density, a long cycle life, low-cost, and high safety based on conversion-type lithium oxide cathodes. Expected outcomes of this project will address the preliminary challenges for the practical use of lithium-oxide, which requires innovative designs of reaction pathways to lithium oxide cathode and lithium metal anode architectures as well as a fundamental in-depth understanding of the electrochemical and growing mechanisms. This project will establish a manufacturing road-map for a novel lithium-ion battery system in Australia with practical reliability by integrating active lithium oxide cathode, optimized electrolyte, and lithium metal anode.Read moreRead less
A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less