Industrial Transformation Training Centres - Grant ID: IC170100022
Funder
Australian Research Council
Funding Amount
$4,420,408.00
Summary
ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess a ....ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess and optimise the healing process. In addition, the Centre will produce data for use in deriving the next-generation of implants, giving rise to improved health outcomes, economic benefits, and a skilled workforce able to advance and perpetuate this important field.Read moreRead less
Novel Drug Delivery Systems. The polymer based structures targeted for production in this project will bring unique capabilities to the field of drug delivery. A multi-drug delivery platform is expected to bring significant improvements in administering therapeutic drugs for a wide range of illnesses and applications. This will have profound effects on the quality of life for those suffering from epilepsy or requiring stent implants. Here we will demonstrate the capabilities of these novel polym ....Novel Drug Delivery Systems. The polymer based structures targeted for production in this project will bring unique capabilities to the field of drug delivery. A multi-drug delivery platform is expected to bring significant improvements in administering therapeutic drugs for a wide range of illnesses and applications. This will have profound effects on the quality of life for those suffering from epilepsy or requiring stent implants. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leader ....Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leaders in their respective fields to address a highly multidisciplinary are of research and will provide excellent training for the PhDs and post doctoral research associates, enabling them to work in and contribute to the development of new biomedical industries in Australia.Read moreRead less
Development and characterisation of novel hydrogel systems for drug delivery. The aims of this project are to develop and characterise hydrogel formulations for delivery of active agents, such as protein drugs, and to examine the biological responses to drug loaded hydrogels. In many medical and industrial fields, it is advantageous to control the release of active agents. Controlled release can decrease the dose of active that must be administered, sustain a more constant level of the agent ....Development and characterisation of novel hydrogel systems for drug delivery. The aims of this project are to develop and characterise hydrogel formulations for delivery of active agents, such as protein drugs, and to examine the biological responses to drug loaded hydrogels. In many medical and industrial fields, it is advantageous to control the release of active agents. Controlled release can decrease the dose of active that must be administered, sustain a more constant level of the agent in the environment and can localise the agent at the site where it is needed. This project will advance the theoretical knowledge of polymer degradation combined with protein release, will develop controlled release hydrogel technology that can be applied to medical devices and will train a postgraduate student in biomaterials and drug delivery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668541
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Infrastructure for design and testing of implantable and non-invasive intelligent medical devices. This application requests infrastructure funding to ensure the capability of the UTS and UNSW biomedical engineering teams to develop tomorrow's biomedical devices. It will enable research in the field of intelligent medical devices, either non-invasive devices (diabetes monitoring, brain-computer interfaces, home telecare) or those which are fully implanted (heart pumps, bionic eyes). Such biomedi ....Infrastructure for design and testing of implantable and non-invasive intelligent medical devices. This application requests infrastructure funding to ensure the capability of the UTS and UNSW biomedical engineering teams to develop tomorrow's biomedical devices. It will enable research in the field of intelligent medical devices, either non-invasive devices (diabetes monitoring, brain-computer interfaces, home telecare) or those which are fully implanted (heart pumps, bionic eyes). Such biomedical devices will save lives and improve the quality of life of many people. The commercial benefit to Australia flows from the international export of such devices. Based on this approach there will be substantial savings in health care costs, with patients able to resume a better quality of life at home, rather than in institutional care.Read moreRead less
Functionalised nanostructured polythiophenes: novel platforms for bionics. The nanostructured organic polymer materials targeted for production in this project will bring unique capabilities to the field of muscle regeneration. A multi-modal stimulation platform is expected to bring significant improvements in muscle cell growth. This will have profound effects on the quality of life for those suffering from neuromuscular disorders or other traumas that require muscle regeneration. This project ....Functionalised nanostructured polythiophenes: novel platforms for bionics. The nanostructured organic polymer materials targeted for production in this project will bring unique capabilities to the field of muscle regeneration. A multi-modal stimulation platform is expected to bring significant improvements in muscle cell growth. This will have profound effects on the quality of life for those suffering from neuromuscular disorders or other traumas that require muscle regeneration. This project will demonstrate the capabilities of these nanostructures in-vitro.Read moreRead less
Wet-Spinning Novel Multi-Functional Bio-Synthetic Platforms. The project will deliver new advanced materials for novel biomedical devices such as nanostructured electrodes and tunable drug delivery systems. It will develop a very versatile and low-cost technology that is well-suited for overcoming some of the current limitations in exploiting nanomaterials in nanoscience and biomedical industries. The research will benefit existing biomedical industries in Australia and provide opportunities for ....Wet-Spinning Novel Multi-Functional Bio-Synthetic Platforms. The project will deliver new advanced materials for novel biomedical devices such as nanostructured electrodes and tunable drug delivery systems. It will develop a very versatile and low-cost technology that is well-suited for overcoming some of the current limitations in exploiting nanomaterials in nanoscience and biomedical industries. The research will benefit existing biomedical industries in Australia and provide opportunities for new start-up companies, as well as potentially attracting biomedical industries from overseas to establish a presence in Australia.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability ....Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability to control cellular responses to implants. Such improved response will result in better health outcomes for patients, and outcomes in the form of papers and intellectual property.
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Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less