Switching the light on cartilage repair. Osteoarthritis is a leading cause of pain and disability in adults and affects 15 per cent of the Australian population. This project will develop a revolutionary new approach to treat joint disorders using smart materials and stem cells. The novel materials and techniques developed will help Australia maintain its leading edge in biotechnology.
Industrial Transformation Training Centres - Grant ID: IC170100022
Funder
Australian Research Council
Funding Amount
$4,420,408.00
Summary
ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess a ....ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess and optimise the healing process. In addition, the Centre will produce data for use in deriving the next-generation of implants, giving rise to improved health outcomes, economic benefits, and a skilled workforce able to advance and perpetuate this important field.Read moreRead less
Novel Drug Delivery Systems. The polymer based structures targeted for production in this project will bring unique capabilities to the field of drug delivery. A multi-drug delivery platform is expected to bring significant improvements in administering therapeutic drugs for a wide range of illnesses and applications. This will have profound effects on the quality of life for those suffering from epilepsy or requiring stent implants. Here we will demonstrate the capabilities of these novel polym ....Novel Drug Delivery Systems. The polymer based structures targeted for production in this project will bring unique capabilities to the field of drug delivery. A multi-drug delivery platform is expected to bring significant improvements in administering therapeutic drugs for a wide range of illnesses and applications. This will have profound effects on the quality of life for those suffering from epilepsy or requiring stent implants. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
Development and characterisation of novel hydrogel systems for drug delivery. The aims of this project are to develop and characterise hydrogel formulations for delivery of active agents, such as protein drugs, and to examine the biological responses to drug loaded hydrogels. In many medical and industrial fields, it is advantageous to control the release of active agents. Controlled release can decrease the dose of active that must be administered, sustain a more constant level of the agent ....Development and characterisation of novel hydrogel systems for drug delivery. The aims of this project are to develop and characterise hydrogel formulations for delivery of active agents, such as protein drugs, and to examine the biological responses to drug loaded hydrogels. In many medical and industrial fields, it is advantageous to control the release of active agents. Controlled release can decrease the dose of active that must be administered, sustain a more constant level of the agent in the environment and can localise the agent at the site where it is needed. This project will advance the theoretical knowledge of polymer degradation combined with protein release, will develop controlled release hydrogel technology that can be applied to medical devices and will train a postgraduate student in biomaterials and drug delivery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668541
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Infrastructure for design and testing of implantable and non-invasive intelligent medical devices. This application requests infrastructure funding to ensure the capability of the UTS and UNSW biomedical engineering teams to develop tomorrow's biomedical devices. It will enable research in the field of intelligent medical devices, either non-invasive devices (diabetes monitoring, brain-computer interfaces, home telecare) or those which are fully implanted (heart pumps, bionic eyes). Such biomedi ....Infrastructure for design and testing of implantable and non-invasive intelligent medical devices. This application requests infrastructure funding to ensure the capability of the UTS and UNSW biomedical engineering teams to develop tomorrow's biomedical devices. It will enable research in the field of intelligent medical devices, either non-invasive devices (diabetes monitoring, brain-computer interfaces, home telecare) or those which are fully implanted (heart pumps, bionic eyes). Such biomedical devices will save lives and improve the quality of life of many people. The commercial benefit to Australia flows from the international export of such devices. Based on this approach there will be substantial savings in health care costs, with patients able to resume a better quality of life at home, rather than in institutional care.Read moreRead less
Design of an electronic guideline-driven decision support framework for home and community telehealth settings. With rapid advancements in the use of telecare-based health support in several emerging clinical areas, integrating these services within a stable guideline-driven decision support framework will support evidence-best practice in this setting, as well as improving efficiencies in clinical work practice and error minimisation through automation. The result could have a profound socio-ec ....Design of an electronic guideline-driven decision support framework for home and community telehealth settings. With rapid advancements in the use of telecare-based health support in several emerging clinical areas, integrating these services within a stable guideline-driven decision support framework will support evidence-best practice in this setting, as well as improving efficiencies in clinical work practice and error minimisation through automation. The result could have a profound socio-economic impact on the community and a sizable impact on healthcare outcomes; notwithstanding the substantial contribution it has to advancing the knowledge of medical decision support systems, supporting the national technology focus on health technology interoperability, and raising the profile of Australia as the foremost leader in the telecare area. Read moreRead less
Hypoxia-mimicking bio-scaffold for skeleton regeneration. The project is to develop bioactive bone grafts to improve bone repair and shorten the recovery time of patients with fractures, degenerative joint diseases, and bone cancer and bone deformities.
Smart Matrix™ approaches towards neo vascularisation in bone repair. Bone injuries cost Australia more than $1 billion annually. The development of a medical device combining novel pro-angiogenic technology, Smart Matrix™, with polymer scaffolds for treatment of bone defects by this project, will facilitate rapid development of a blood supply within the defect, aiding bone growth and reducing overall costs compared to current treatments.
Elucidating surface-mediated permissive cues for cellular differentiation. This project will develop a novel biomaterial platform technology that will enable firstly the probing and thereafter the control of the cellular pathways of adult mesenchymal stem cells. These fundamental insights will be translated into novel stem cell culture ware products that will enable clinically relevant, functional tissue repair and regeneration.
Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less