Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Intra-household resource allocations of older couples. This project aims to analyse processes and outcomes within older households using national, large-scale representative data and mixed methods research design. In an ageing population where households are becoming responsible for provisioning retirement needs, understanding what happens in older couple households is important. The project expects to influence policy by generating evidence relevant to the design of regulations governing the al ....Intra-household resource allocations of older couples. This project aims to analyse processes and outcomes within older households using national, large-scale representative data and mixed methods research design. In an ageing population where households are becoming responsible for provisioning retirement needs, understanding what happens in older couple households is important. The project expects to influence policy by generating evidence relevant to the design of regulations governing the allocation of superannuation assets, tax incentives for alternative forms of retirement savings, asset and income tests on the Age Pension, and initiatives targeting older Australians’ financial literacy.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Drug enhancement and experimentation. This project aims to research the chemical practices of sexual and gender minorities in Australia and investigate how health agencies have sought to deal with them. Drugs are increasingly and widely used in pharmaceutical markets and lifestyle practices. As pharmaceutical markets expand, the distinction between therapeutic and illicit drugs becomes unclear. Drug consumption can give rise to serious dangers in certain circumstances. This project is expected t ....Drug enhancement and experimentation. This project aims to research the chemical practices of sexual and gender minorities in Australia and investigate how health agencies have sought to deal with them. Drugs are increasingly and widely used in pharmaceutical markets and lifestyle practices. As pharmaceutical markets expand, the distinction between therapeutic and illicit drugs becomes unclear. Drug consumption can give rise to serious dangers in certain circumstances. This project is expected to better understand drugs and medication use and improve public health services.Read moreRead less
Corporate political activity of tobacco, alcohol and gambling companies in Australia. This project investigates how tobacco, alcohol and gambling industries influence the policy process, by stalling or defeating the implementation of effective public health policies in favour of ones which do not affect profit. The study will develop guidelines for industry-government interaction to ensure maximum public benefit.
Effective clinical handover communication: improving patient safety, experiences and outcomes. Communication in clinical handover (transfer of responsibility for patient care) plays a causal role in many adverse events. This project will contribute new knowledge for improvements in handover communication which will be shared across hospitals and health departments nationally to improve patient safety and reduce healthcare costs.
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Understanding collaboration between the arts and sciences. This project aims to undertake a detailed examination of how the arts and sciences can work together to address the complex challenges of contemporary life. This will be addressed by undertaking the first cultural history of the experiment. Experimentation is common to the arts and sciences, and thinking about the long history of experimental practices in both fields will help build a bridge between them. This project will examine in de ....Understanding collaboration between the arts and sciences. This project aims to undertake a detailed examination of how the arts and sciences can work together to address the complex challenges of contemporary life. This will be addressed by undertaking the first cultural history of the experiment. Experimentation is common to the arts and sciences, and thinking about the long history of experimental practices in both fields will help build a bridge between them. This project will examine in detail past and present collaboration. An expected outcome is the development of models to support solving of complex contemporary problems. It will also raise awareness about the importance of the arts to knowledge-making practices.Read moreRead less
Public health approach to child abuse and neglect: antecedents, outcomes and international comparisons of trends. Child maltreatment is a significant public health issue. Findings will identify characteristics of at-risk children, families and communities; mental health and juvenile justice outcomes. Findings will be used to develop policy recommendations for intervention and prevention strategies to reduce vulnerability and improve monitoring of maltreatment.