Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being dev ....The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being developed in several States following pay equity inquiries. Expected outcomes include enhanced comprehension of the reproduction of pay inequality and evidence to assist the advancement of pay equity through identified mechanisms and strategies.Read moreRead less
From science to policy: quantifying and managing the risk of mosquito borne disease in the context of climate change. It is important to assess and manage the health risks of climate change. This research will create fundamental knowledge and practical skills on the interdisciplinary assessment and management of health risks of climate change, and explore policy ramifications of research outcomes in this study.
The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) ....The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) in England and Europe from 1600 to 1750, against the backdrop of the rise of Cartesianism. The anticipated outcome is greater awareness of an enduring feminist tradition within the history of philosophy. The expected social benefits include a shift in public thinking about feminist history and women in philosophy.Read moreRead less
Calibration Free Coulometric Sensors Based on Polymeric Thin Layer Films. The world faces enormous environmental and clinical challenges that require accurate data from remote deployable and disposable sensors. Many key parameters important to global warming (carbon dioxide cycle) and clinical diagnostics (blood electrolytes) may be assessed with a polymeric membrane sensing technology, but the measurement principle is not sufficiently robust for remote sensing applications. This research will m ....Calibration Free Coulometric Sensors Based on Polymeric Thin Layer Films. The world faces enormous environmental and clinical challenges that require accurate data from remote deployable and disposable sensors. Many key parameters important to global warming (carbon dioxide cycle) and clinical diagnostics (blood electrolytes) may be assessed with a polymeric membrane sensing technology, but the measurement principle is not sufficiently robust for remote sensing applications. This research will make this possible by adapting calibration free measurement principles (coulometry, or charge counting) to this class of sensors, where a thin layer of sample solution will be depleted by instrumental control. This forms the scientific basis for successfully tackling the measurement challenges of the future.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
A Cultural and Intellectual History of Automated Labour . This project will trace how debates about labour automation have been shaped by cultural depictions of work, from the eighteenth century to today. It will produce new knowledge about how people have viewed industrial transformation, from the steam engine to modern forms of labour saving - electronic, digital, biological, and artificial intelligence. The project will combine historical study with an examination of the way artists and write ....A Cultural and Intellectual History of Automated Labour . This project will trace how debates about labour automation have been shaped by cultural depictions of work, from the eighteenth century to today. It will produce new knowledge about how people have viewed industrial transformation, from the steam engine to modern forms of labour saving - electronic, digital, biological, and artificial intelligence. The project will combine historical study with an examination of the way artists and writers have responded to labour automation. Expected benefits include informing public debate about the future of work, and shaping policy in arts-science museums and laboratories. Outcomes will include publications, public forums, conferences, training of research students and international collaboration. Read moreRead less
Farm Women, Networks and ICTs. Considerable national funds have been spent on brining rural Australians online. In the previous year over half of those living in non-metropolitan Australian accessed the internet. However, little is known about how new technologies are being integrated into the daily lives of rural people. This research moves from quantifying technology take-up in rural Australia and describing the possibilities of what new technologies may offer rural people, to analysing and cr ....Farm Women, Networks and ICTs. Considerable national funds have been spent on brining rural Australians online. In the previous year over half of those living in non-metropolitan Australian accessed the internet. However, little is known about how new technologies are being integrated into the daily lives of rural people. This research moves from quantifying technology take-up in rural Australia and describing the possibilities of what new technologies may offer rural people, to analysing and critiquing the extent to which these possibilities are being realised. It will inform policy on rural and regional technology access and use.Read moreRead less
Effective clinical handover communication: improving patient safety, experiences and outcomes. Communication in clinical handover (transfer of responsibility for patient care) plays a causal role in many adverse events. This project will contribute new knowledge for improvements in handover communication which will be shared across hospitals and health departments nationally to improve patient safety and reduce healthcare costs.