This study aims to elucidate central pathways which can be manipulated to drive the storage of excess energy away from fat and instead directing it into the production of bone mass. Having identified leptin-responsive NPY neurons as important in the control of energy partitioning, we will focus on manipulating these neurons in the hypothalamus using innovative technology to alter body composition. This research has the potential to result in novel treatments for obesity and osteoporosis.
Feeding Behaviour And Obesity Development: Identification Of Novel Intervention Points
Funder
National Health and Medical Research Council
Funding Amount
$923,668.00
Summary
Appetite and food intake is regulated by specific neuronal structures in the brain. The most important area is the hypothalamus from which many neuronal pathways originate to control specific aspects of feeding behaviour and energy usage in the brain and the rest of the body. To better understand the contribution individual neuronal populations make to drive excess food intake we propose a new approach to identify this, making new treatment options for eating disorders and obesity possible.
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem ....Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem cell-derived mechanosensory neurons as a platform to extensively study their molecular and functional properties. The significant benefits are the advancement of knowledge in the human mechanosensory system, which to date has been lacking, and in the long-term progress commercial development of novel drugs.Read moreRead less
The pressures of modern manhood. Mapping the impact of homophobia on the lives of Australian men. this study will construct a detailed map of the impact of homophobia on men;s behaviour, lifestyles and risk-taking (gay or not). It explores the possibility that through devices like taboo and loss of face homophobia can (i) make certain behaviours and life patterns unpalatable and alienate men from safer, healthier behaviours; (ii) block retreat from danger : and (iii) promote risky, antisocial, h ....The pressures of modern manhood. Mapping the impact of homophobia on the lives of Australian men. this study will construct a detailed map of the impact of homophobia on men;s behaviour, lifestyles and risk-taking (gay or not). It explores the possibility that through devices like taboo and loss of face homophobia can (i) make certain behaviours and life patterns unpalatable and alienate men from safer, healthier behaviours; (ii) block retreat from danger : and (iii) promote risky, antisocial, hyper-masculine posturing. from the innovative perspective of the interplay of homophobia with masculinity, we expect to uncover key insights into how homophobia makes an important contribution to the pressures of modern manhood.Read moreRead less
Gender, peacebuilding and the politics of space: a critical examination of United Nations peacebuilding practices. More than half of all peace agreements fail within five years. In response to this dismal statistic, the United Nations (UN) recently began to prioritise gender matters in peacebuilding operations, recognising that gender equality is key to building sustainable peace. This project examines how gender justice is addressed in United Nations peacebuilding policy and practice.
Domestic Subversions: maternalism and cross-cultural histories. This project will assist in the processes of reconciliation, by fostering a sense of a shared history, and increasing public awareness of the complexity of race relations histories in Australia. It will redress a significant gap in Australian knowledge and literature. Very little is known about the history of Aboriginal domestic workers and their relationships with their white employers in Australia, despite growing awareness of the ....Domestic Subversions: maternalism and cross-cultural histories. This project will assist in the processes of reconciliation, by fostering a sense of a shared history, and increasing public awareness of the complexity of race relations histories in Australia. It will redress a significant gap in Australian knowledge and literature. Very little is known about the history of Aboriginal domestic workers and their relationships with their white employers in Australia, despite growing awareness of the significance of domestic service in Aboriginal child removal policies. The project will also assist in establishing Australian historical scholarship at the forefront of leading international research initiatives in gender, race and colonialism studies. Read moreRead less
Inner Eurasia: A World History of Eurasia's Heartlands. Inner Eurasia has played a distinctive and significant role in world history, particularly in the twentieth century when it was the heartland of world communism. Australia's history has been shaped profoundly by the political, military, cultural and commercial impact of the region's great empires. This project will expand Australian understanding of the region, and raise Australia's international visibility and competitiveness in both Inner ....Inner Eurasia: A World History of Eurasia's Heartlands. Inner Eurasia has played a distinctive and significant role in world history, particularly in the twentieth century when it was the heartland of world communism. Australia's history has been shaped profoundly by the political, military, cultural and commercial impact of the region's great empires. This project will expand Australian understanding of the region, and raise Australia's international visibility and competitiveness in both Inner Eurasian and World history. It will attract undergraduate and graduate students and international scholars. Its world history approach will augment Macquarie's significant contributions to the Australian National History Curriculum.Read moreRead less