Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings in ....Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings into the blueprint for a next-generation infectious disease surveillance system for Australia. We will use a simulation-evaluation approach, coupling methods from infectious disease modelling with those from information theory optimal design. Outcomes will enable more tailored and effective pandemic response.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101708
Funder
Australian Research Council
Funding Amount
$406,821.00
Summary
New directions for using brain stimulation to understand brain function. Neuroplasticity is of fundamental importance to brain function as it mediates learning, memory and development. Deficits in neuroplasticity are observed in a number of neurological conditions and thought to contribute to cognitive dysfunction. This study is designed to develop a better understanding of the neurochemical and genetic factors impacting on neuroplasticity. In addition, it aims to (i) upregulate brain connectivi ....New directions for using brain stimulation to understand brain function. Neuroplasticity is of fundamental importance to brain function as it mediates learning, memory and development. Deficits in neuroplasticity are observed in a number of neurological conditions and thought to contribute to cognitive dysfunction. This study is designed to develop a better understanding of the neurochemical and genetic factors impacting on neuroplasticity. In addition, it aims to (i) upregulate brain connectivity in a precise and targeted manner, (ii) elicit functional increases in cognitive performance and (iii) demonstrate the relationship between functional connectivity and cognition. Outcomes include a better understanding of plasticity in the brain & a enhanced capacity to examine and modulate brain plasticity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100027
Funder
Australian Research Council
Funding Amount
$467,754.00
Summary
Making a life with less: youth underemployment over the life course. This project aims to investigate the experiences and impacts of underemployment on young people. Using high-quality longitudinal data and qualitative interviews, this project expects to generate new, foundational knowledge about the employment pathways young people take following underemployment and the strategies they use to mitigate its effects. In doing so, this project aims to reveal the impacts underemployment has on young ....Making a life with less: youth underemployment over the life course. This project aims to investigate the experiences and impacts of underemployment on young people. Using high-quality longitudinal data and qualitative interviews, this project expects to generate new, foundational knowledge about the employment pathways young people take following underemployment and the strategies they use to mitigate its effects. In doing so, this project aims to reveal the impacts underemployment has on young people’s lives within and outside work, including their relationships, family formation and well-being. This much-needed research aims to provide significant benefits for policymakers and service providers that improve the lives of young people.Read moreRead less
Engineering approaches towards atomic imaging of bacterial cells. This project aims to develop novel approaches for analysis of single biological cells at atomic scale. The project will first develop an approach by utilising nanoscale ion beam to interact with the frozen cells in a controllable manner, followed by performing nanoscale dissection and analyses. By introducing engineered two-dimensional materials, namely graphene, atomic resolution three-dimensional imaging of the cellular chemistr ....Engineering approaches towards atomic imaging of bacterial cells. This project aims to develop novel approaches for analysis of single biological cells at atomic scale. The project will first develop an approach by utilising nanoscale ion beam to interact with the frozen cells in a controllable manner, followed by performing nanoscale dissection and analyses. By introducing engineered two-dimensional materials, namely graphene, atomic resolution three-dimensional imaging of the cellular chemistry will become feasible, which will shed light on various fundamental mechanisms inside the cells. This will provide significant benefits upon success, and will impact a wide spectrum of fields from understanding cellular functions to developing effective drugs.Read moreRead less
COVID-19, health and labour market marginalisation . This project aims to investigate the impact of the COVID-19 pandemic on labour market marginalisation in Australia. It seeks to generate new insights about whether the global economic shock had a disproportionately negative effect on the employment circumstances of working-age Australians with mental health and musculoskeletal/pain conditions, which are the leading causes of disability in Australia. The expected outcomes of this project includ ....COVID-19, health and labour market marginalisation . This project aims to investigate the impact of the COVID-19 pandemic on labour market marginalisation in Australia. It seeks to generate new insights about whether the global economic shock had a disproportionately negative effect on the employment circumstances of working-age Australians with mental health and musculoskeletal/pain conditions, which are the leading causes of disability in Australia. The expected outcomes of this project include improved policy responses to direct effective support and assistance to those with the greatest need, and new resources for the research community. This should lead to significant benefits through reduced inequalities and improved social, economic and workforce outcomes for vulnerable Australians.Read moreRead less
Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus t ....Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus to alter stem cell aging and fate. The findings will provide critical information required for the future development of assays to measure cell potency and instructive biomaterials to drive stem cell expansion and tissue-regeneration and will have impact by underpinning future advances in stem cell technologies.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101224
Funder
Australian Research Council
Funding Amount
$351,996.00
Summary
Labour, race and belonging: strengthening Rural Workforces and Communities. This project aims to strengthen understandings of race and labour relations in Australia’s horticultural industry. Horticulture is Australia’s third largest agricultural industry and the seasonal nature of work in this industry poses challenges for workforce recruitment and development. Such challenges are often framed in terms of economic and policy considerations, but debates about the ‘backpacker tax’ and exploitation ....Labour, race and belonging: strengthening Rural Workforces and Communities. This project aims to strengthen understandings of race and labour relations in Australia’s horticultural industry. Horticulture is Australia’s third largest agricultural industry and the seasonal nature of work in this industry poses challenges for workforce recruitment and development. Such challenges are often framed in terms of economic and policy considerations, but debates about the ‘backpacker tax’ and exploitation suggest that there are also complex racial dimensions associated with the industry. Using an innovative historical-anthropological approach, this project will generate new insights into race and labour relations that can improve the equity and sustainability of horticultural industry workforces, and strengthen belonging within rural communities.Read moreRead less
Managing at the Margins: Women Making it Work in Precarious Times. This project aims to investigate the economic, social and emotional impacts of precarious work on women. Focusing on the challenges that arise from juggling precarious work with care responsibilities and/or demands from the social support system, the project identifies the strategies women have to manage these demands, and the impacts these demands have on everyday lives across different life stages. By combining otherwise separa ....Managing at the Margins: Women Making it Work in Precarious Times. This project aims to investigate the economic, social and emotional impacts of precarious work on women. Focusing on the challenges that arise from juggling precarious work with care responsibilities and/or demands from the social support system, the project identifies the strategies women have to manage these demands, and the impacts these demands have on everyday lives across different life stages. By combining otherwise separate bodies of literature with innovative quantitative and qualitative data, the project seeks to generate new knowledge about the impacts of precarious work on women and families. This knowledge is expected to inform policies and services to improve women’s lives and promote economic inclusion and social cohesion.Read moreRead less
Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanism ....Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanisms for large scale stem cell differentiation. The expected outcomes are a significant advancement in knowledge in the field of tissue engineering and more efficient methodology for patient-derived stem cell therapy. This will provide new pathways to improving stem cell therapy for tissue engineering applications.Read moreRead less