We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
THE EFFECT OF STRESS AND ENVIRONMENTAL ENRICHMENT ON DISEASE PROGRESSION IN MESIAL TEMPORAL LOBE EPILEPSY
Funder
National Health and Medical Research Council
Funding Amount
$578,201.00
Summary
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
Work and Social Cohesion under Globalisation. The project will explore how innovation and improvement in productivity can be accommodated with notions of fairness at workplace and industry level. The impact of increasingly competitive markets on the nature of work and society and the relationships between employers and employees in five industries: finance, tourism, health, ICT and automotive components, will be examined. The views of a wide cross-section of employees and managers in five key i ....Work and Social Cohesion under Globalisation. The project will explore how innovation and improvement in productivity can be accommodated with notions of fairness at workplace and industry level. The impact of increasingly competitive markets on the nature of work and society and the relationships between employers and employees in five industries: finance, tourism, health, ICT and automotive components, will be examined. The views of a wide cross-section of employees and managers in five key industries, complemented by existing survey data, will be analysed. A major outcome will be five industry workshops promoting productivity, partnership and social cohesion in a competitive global environment. Policy implications for the wider economy will be developed in the final report.Read moreRead less
Optimising Early Interventions For Young People With Emerging Mood Disorder
Funder
National Health and Medical Research Council
Funding Amount
$2,653,052.00
Summary
One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, i ....One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, imaging, immunological or clinical methods.Read moreRead less
Rural adjustment or structural transformation? Discovering the destinations of exiting farm families. The findings of this research will assist local, State and Federal governments to intervene effectively in processes of regional and rural structural adjustment. It will generate economic benefits by recommending policies that facilitate growth and promote sustainable rural businesses while at the same time sheltering rural communities and individual households from adverse outcomes. It will con ....Rural adjustment or structural transformation? Discovering the destinations of exiting farm families. The findings of this research will assist local, State and Federal governments to intervene effectively in processes of regional and rural structural adjustment. It will generate economic benefits by recommending policies that facilitate growth and promote sustainable rural businesses while at the same time sheltering rural communities and individual households from adverse outcomes. It will contribute social benefits by identifying policies to improve the outcomes of rural adjustment for families and individuals. The new knowledge it provides will inform the politics of regional change and remove some of the uncertainties that currently impede the implementation of rural adjustment policies.Read moreRead less
Microeconomic effects of Australian natural disasters. This project aims to describe and identify the effects of Australian natural disasters – such as the Black Saturday bushfires and the Brisbane floods – on important microeconomic outcomes, including health, education and employment. Natural disasters have profound economic and social effects on individuals and communities. This project intends to bring evidence on how disasters affect individuals and how the effects can be lessened. The proj ....Microeconomic effects of Australian natural disasters. This project aims to describe and identify the effects of Australian natural disasters – such as the Black Saturday bushfires and the Brisbane floods – on important microeconomic outcomes, including health, education and employment. Natural disasters have profound economic and social effects on individuals and communities. This project intends to bring evidence on how disasters affect individuals and how the effects can be lessened. The project expects to inform policy-makers on these critical issues by analysing field, survey and administrative data on individuals before and after past disasters.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less
Working longer, staying healthy and keeping productive. Working longer, staying healthy and keeping productive. This project aims to develop a policy suite to respond to an older workforce. By 2060, nearly half of Australians aged 64 or older will be employed. Failure to address their health problems could threaten Australia’s economy, tax base and provision of health and care services. This collaboration between national policy portfolios (employment, social services, workplace health and socia ....Working longer, staying healthy and keeping productive. Working longer, staying healthy and keeping productive. This project aims to develop a policy suite to respond to an older workforce. By 2060, nearly half of Australians aged 64 or older will be employed. Failure to address their health problems could threaten Australia’s economy, tax base and provision of health and care services. This collaboration between national policy portfolios (employment, social services, workplace health and social equity) and expert scientists in work, health, social equality and policy process intends to reveal the diversity of older workers’ work-health dilemmas and effective ways for national policies to solve them. The policy suite will promote financial independence and meet social goals of equity and healthy ageing.Read moreRead less
Impact of parents' employment on children's well-being: The influence of employment quality, time and activities with children, and parenting practices. Most Australian children now grow-up in families where both their mother and their father are employed. Using a new national dataset, this research examines how parents' working conditions are related to children's well-being. It is proposed that parents' availability, resources, and family functioning mediate between parental employment and chi ....Impact of parents' employment on children's well-being: The influence of employment quality, time and activities with children, and parenting practices. Most Australian children now grow-up in families where both their mother and their father are employed. Using a new national dataset, this research examines how parents' working conditions are related to children's well-being. It is proposed that parents' availability, resources, and family functioning mediate between parental employment and child outcomes. The Growing-Up in Australia study (available in 2005) surveys 10,000 children, combining measures of child well-being, existing validated measures of work conditions and family functioning, with a new child-focused diary that measures time and activities undertaken with children. New knowledge generated will inform future policy development.Read moreRead less