A history of Australia's 1998 waterfront dispute. The project will produce an innovative account of Australia's Easter 1998 waterfront dispute, within the context of a wider body of research on diverse but related social perspectives. The aim is to not only enhance understanding of the event, but to employ the event to enhance understanding of social relations. The project is based on the hypothesis that the social memory is more complex, multi-layered and contextual than public accounts suggest ....A history of Australia's 1998 waterfront dispute. The project will produce an innovative account of Australia's Easter 1998 waterfront dispute, within the context of a wider body of research on diverse but related social perspectives. The aim is to not only enhance understanding of the event, but to employ the event to enhance understanding of social relations. The project is based on the hypothesis that the social memory is more complex, multi-layered and contextual than public accounts suggest. By incorporating the study of multiple perspectives, the aim is to disclose a different and more insightful memory of both the event and the society in which it occurred.Read moreRead less
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
From rivers of gold to the clickstream: Newspapers and quality journalism in the Internet Age. This project will enhance Australian democracy by providing a scholarly basis for public discussion about the ways that quality journalism can survive in the Internet age. It will create knowledge about the specifically Australian experience of newspapers' transition to online media services and will thus help Australian citizens and journalists engage in global debates about journalism futures. It wil ....From rivers of gold to the clickstream: Newspapers and quality journalism in the Internet Age. This project will enhance Australian democracy by providing a scholarly basis for public discussion about the ways that quality journalism can survive in the Internet age. It will create knowledge about the specifically Australian experience of newspapers' transition to online media services and will thus help Australian citizens and journalists engage in global debates about journalism futures. It will create knowledge about the workplace conditions that foster quality journalism. It will showcase Australian research in international scholarly debate within the field of Journalism Studies.Read moreRead less
Neuronal Substrate Of Choice In The Rat Whisker System
Funder
National Health and Medical Research Council
Funding Amount
$405,851.00
Summary
Humans and other animals can optimise their goal-directed behaviour by linking stimuli or actions to consequent positive and negative rewards. How does an animal generate such associations, and make decisions in the natural environment where the associations are often uncertain, at times contradictory, and continuously changing? This project uses rat whisker system as an animal model to identify the neuronal basis of perceptual decision making and the role of context.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
THE EFFECT OF STRESS AND ENVIRONMENTAL ENRICHMENT ON DISEASE PROGRESSION IN MESIAL TEMPORAL LOBE EPILEPSY
Funder
National Health and Medical Research Council
Funding Amount
$578,201.00
Summary
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
A Multi-national Trial To Predict Treatment Response In Subtypes Of Depression
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Treatment of MDD using trial and error can have serious consequences. It can prolong the patient’s suffering (depression is associated with substantial morbidity, and mortality), prolong their absence from work and other productive activity and increase the burden on their family-carers. This multi-national study will collect genetics, brain function and behavioural data from a large number of participants, allowing for sensitive predictors of response to be determined.
The Impact Of Globalisation On Employment Relations: A Comparison Of The Auto And Banking Industries In Australia And Korea. The project compares the impact of globalisation on employment relations in Australia and South Korea by analysing changes in the auto and banking industries since the mid 1990s. It is expected that the interactions between economic factors, institutional arrangements and strategic decision making will have led to both continuity and change in employment relations during t ....The Impact Of Globalisation On Employment Relations: A Comparison Of The Auto And Banking Industries In Australia And Korea. The project compares the impact of globalisation on employment relations in Australia and South Korea by analysing changes in the auto and banking industries since the mid 1990s. It is expected that the interactions between economic factors, institutional arrangements and strategic decision making will have led to both continuity and change in employment relations during this period. The study will introduce a new theoretical dimension to comparative industrial relations by testing an ?interaction? approach. It will also provide a deeper understanding of the reasons for similarities and differences between employment relations in Australia and South Korea and indicate likely future developments.Read moreRead less