We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
The Role Of Corticothalamic Feedback On The Response Dynamics Of Thalamic Neurons
Funder
National Health and Medical Research Council
Funding Amount
$351,852.00
Summary
A fundamental question in neuroscience is how the brain selectively processes sensory information to generate a reliable representation of the world. Positioned in the centre of the brain, the thalamus plays a key role in sensory processing. This project investigates how the interaction between thalamus and cortex shapes the selection and gating of sensory information. This is a fundamental question in basic neuroscience with the potential to increase our knowledge about attentional deficits.
Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining ....Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining fertility and encouraging women into paid work. Identifying measures that most support men and women to balance work-family commitments, to spend adequate time with their children and social networks, and most facilitate female workforce participation, will promote national wellbeing. Read moreRead less
The Changing Nature of China's Enterprise Culture. China is one of Australia's most important trading partners. Understanding the transformation now underway in the enterprise culture of China's industrial system is essential in safeguarding Australia's future economic interests. Through in-depth research inside a representative sample of Chinese enterprises with different forms of ownership, this project will provide much needed insights. The findings will be of interest to Australia's academic ....The Changing Nature of China's Enterprise Culture. China is one of Australia's most important trading partners. Understanding the transformation now underway in the enterprise culture of China's industrial system is essential in safeguarding Australia's future economic interests. Through in-depth research inside a representative sample of Chinese enterprises with different forms of ownership, this project will provide much needed insights. The findings will be of interest to Australia's academic community, our government, NGOs and trade unions.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less
Working longer, staying healthy and keeping productive. Working longer, staying healthy and keeping productive. This project aims to develop a policy suite to respond to an older workforce. By 2060, nearly half of Australians aged 64 or older will be employed. Failure to address their health problems could threaten Australia’s economy, tax base and provision of health and care services. This collaboration between national policy portfolios (employment, social services, workplace health and socia ....Working longer, staying healthy and keeping productive. Working longer, staying healthy and keeping productive. This project aims to develop a policy suite to respond to an older workforce. By 2060, nearly half of Australians aged 64 or older will be employed. Failure to address their health problems could threaten Australia’s economy, tax base and provision of health and care services. This collaboration between national policy portfolios (employment, social services, workplace health and social equity) and expert scientists in work, health, social equality and policy process intends to reveal the diversity of older workers’ work-health dilemmas and effective ways for national policies to solve them. The policy suite will promote financial independence and meet social goals of equity and healthy ageing.Read moreRead less
Work, care, retirement and health: ageing agendas. This project will undertake a gendered analysis of how Australians can retire well, taking account of their key resources (such as work, superannuation, the aged pension, and other assets) and key demands (such as to work longer and to care for others in the context of an ageing population and a more feminised workforce).
Retention of the Aboriginal health and disability workforce. This project aims to develop evidence-based retention strategies for the Indigenous frontline health and disability workforces. Indigenous people in these roles are critical to improving access to culturally safe and effective services and support for Indigenous Australians. The availability of culturally safe services, interventions and support will assist in closing the gap in health, education and socio-economic outcomes between Ind ....Retention of the Aboriginal health and disability workforce. This project aims to develop evidence-based retention strategies for the Indigenous frontline health and disability workforces. Indigenous people in these roles are critical to improving access to culturally safe and effective services and support for Indigenous Australians. The availability of culturally safe services, interventions and support will assist in closing the gap in health, education and socio-economic outcomes between Indigenous and non-Indigenous Australians. This project aims to uncover the factors that influence Indigenous front line workers to stay in their crucial roles. The findings will be translated into culturally-appropriate workforce retention strategies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100015
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Australian Facility for Taphonomic Experimental Research . Australian facility for taphonomic experimental research: The aim of this project is to establish a unique Australian research facility dedicated to studying the physical, chemical, and biological processes of human decomposition. This facility will be the first of its kind in Australia and the Southern Hemisphere, drawing together a collaborative team of experts in a broad range of taphonomy disciplines. The results of the research are ....Australian Facility for Taphonomic Experimental Research . Australian facility for taphonomic experimental research: The aim of this project is to establish a unique Australian research facility dedicated to studying the physical, chemical, and biological processes of human decomposition. This facility will be the first of its kind in Australia and the Southern Hemisphere, drawing together a collaborative team of experts in a broad range of taphonomy disciplines. The results of the research are expected to advance our limited understanding of the taphonomic processes acting on remains in a natural Australian environment. The outcomes will assist police and forensic services to improve their procedures for searching, locating, recovering, and identifying missing persons, victims of homicide, and victims of disaster on both a national and international scale.Read moreRead less
Reducing flood loss - A data-assimilation framework for improving forecasting capability in sparsely gauged regions. Floods are the biggest and severest natural disaster we face year after year. Furthermore, there has been little improvement in our capability to prevent flood damage over past decades. This research proposes a paradigm shift in the way flood forecasting, warning and evacuation proceeds, using 21st century technologies for collecting and incorporating flood related data into exist ....Reducing flood loss - A data-assimilation framework for improving forecasting capability in sparsely gauged regions. Floods are the biggest and severest natural disaster we face year after year. Furthermore, there has been little improvement in our capability to prevent flood damage over past decades. This research proposes a paradigm shift in the way flood forecasting, warning and evacuation proceeds, using 21st century technologies for collecting and incorporating flood related data into existing modelling platforms. It is argued that assimilating real-time satellite soil moisture data into flood models can increase accuracy manifold, even if the images are uncertain. The understanding gained in course of the proposed project has the potential to significantly reduce the damage caused year after year, especially in the data poor regions of the world.Read moreRead less