Relaxin-3/RXFP3 Signalling And Regulation Of Affective Behaviour _ Studies In Normal/transgenic Mice
Funder
National Health and Medical Research Council
Funding Amount
$578,268.00
Summary
Mental illness is a significant social and economic burden worldwide and knowledge of the underlying causes and more effective therapies are required. Our research aims to use pre-clinical animal models to characterize a little studied brain neuronal network implicated in control of arousal and stress, which could lead to improved treatment of psychiatric disorders such as depression.
A history of Australia's 1998 waterfront dispute. The project will produce an innovative account of Australia's Easter 1998 waterfront dispute, within the context of a wider body of research on diverse but related social perspectives. The aim is to not only enhance understanding of the event, but to employ the event to enhance understanding of social relations. The project is based on the hypothesis that the social memory is more complex, multi-layered and contextual than public accounts suggest ....A history of Australia's 1998 waterfront dispute. The project will produce an innovative account of Australia's Easter 1998 waterfront dispute, within the context of a wider body of research on diverse but related social perspectives. The aim is to not only enhance understanding of the event, but to employ the event to enhance understanding of social relations. The project is based on the hypothesis that the social memory is more complex, multi-layered and contextual than public accounts suggest. By incorporating the study of multiple perspectives, the aim is to disclose a different and more insightful memory of both the event and the society in which it occurred.Read moreRead less
Understanding low skilled men's access to jobs: An occupational case-study approach. The withdrawal of low skilled men from the labour force has been substantial over recent decades. As many as 40% of men without post-school qualifications do not have full-time jobs. This development has many negative social consequences. It damages the affected men's wellbeing, and that of their families. It reduces labour supply at a time of labour shortages. It increases dependency on the welfare system. ....Understanding low skilled men's access to jobs: An occupational case-study approach. The withdrawal of low skilled men from the labour force has been substantial over recent decades. As many as 40% of men without post-school qualifications do not have full-time jobs. This development has many negative social consequences. It damages the affected men's wellbeing, and that of their families. It reduces labour supply at a time of labour shortages. It increases dependency on the welfare system. This project will develop new understandings of the barriers low skill men face when they seek jobs in areas of rising employment, such as the service sector. It will provide an assessment of the possibilities of overcoming these barriers, and develop ideas about how best to enhance low skilled men's access to good jobs. Read moreRead less
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
The Role Of Stem-progenitor Cells In Regeneration Of Mouse Endometrium.
Funder
National Health and Medical Research Council
Funding Amount
$311,938.00
Summary
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Central Neural Circuits Subserving Nutrient–activated Thermogenesis - The Basis Of Post Prandial Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$766,207.00
Summary
Studies of “energy burning” brown fat, including its importance in the determination of obesity in humans and the potential to increase its capacity by turning white fat into brown-like fat are currently foremost in obesity research. Here we study the detail of brain pathways that dictate brown fat activity after a meal resulting in the burning of ingested calories and reduction of body weight. The results will give us a better idea of how we can harness brown fat to combat obesity.
Work, life and sustainable living: how work, household and community life interact to affect environmental behaviours and outcomes. The project addresses the research priority of an environmentally sustainable Australia. It examines how the circumstances and interaction of work, home and community affect capacities to reduce negative environmental impacts especially workplace and household transport, waste, energy and water use practices. The project brings the changing configuration of work to ....Work, life and sustainable living: how work, household and community life interact to affect environmental behaviours and outcomes. The project addresses the research priority of an environmentally sustainable Australia. It examines how the circumstances and interaction of work, home and community affect capacities to reduce negative environmental impacts especially workplace and household transport, waste, energy and water use practices. The project brings the changing configuration of work to the fore, addressing a gap in current research. It examines the implications for environmental change of the temporal and spatial organisation of 'work-life', including analysis of socio-economic and gender differences, informing practice and theory about how workers, workplaces and households can change for the better, in the interests of a sustainable, socially inclusive society.Read moreRead less
The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undertake studies to better understand effective immunity against HIV and hepatitis C, allowing the rational design and testing of novel vaccines and treatments. The Program brings together a team of researchers with skills in basic virology and immunology with those providing expertise in translating findings in the laboratory into human clinical trials.