Assessment Of Bilateral Oedema By Bioelectrical Impedance Analysis
Funder
National Health and Medical Research Council
Funding Amount
$180,000.00
Summary
Swelling of tissue due to fluid accumulation, known as oedema, is one of the earliest signs of diseases such as kidney failure, burn injury or lymphedema. All of these are not uncommon conditions. Lymphedema, for example, is a common sequela of radiotherapy or surgery in the treatment of malignancies such as breast, uterine, and prostatic carcinoma. It is reported to occur in up to 40% of patients depending on the type of surgery and whether or not the patient received radiotherapy. It is estima ....Swelling of tissue due to fluid accumulation, known as oedema, is one of the earliest signs of diseases such as kidney failure, burn injury or lymphedema. All of these are not uncommon conditions. Lymphedema, for example, is a common sequela of radiotherapy or surgery in the treatment of malignancies such as breast, uterine, and prostatic carcinoma. It is reported to occur in up to 40% of patients depending on the type of surgery and whether or not the patient received radiotherapy. It is estimated that at any time 100000 women are suffering from post- mastectomy lymphedema in Australia alone. Treatment of breast cancer alone therefore, given the incidence of the disease, produces a large at-risk population. Add to this other causes of oedema and the magnitude of the problem becomes clearly apparent. The presence of chronic oedema is often a disfiguring and disabling disorder, usually accompanied by pain, recurrent infection, reduced mobility and impaired function. In acute oedema the problem often resolves with recovery from the underlying pathology. In chronic oedema, progression may be arrested by early intervention including complex physical therapy (exercise regimen, compression bandaging, and massage) which is effective in reducing limb volume, in improving the quality of life, function and body image of patients. Although the assessment of oedema is clearly of clinical importance, relatively few objective and accurate techniques for its measurement exist. Research conducted over the past decade by the applicants has pioneered the Use of Bioelectrical Impedance Analysis for the assessment of lymphedema. This study aims to translate this basic research into clinical practice. Sensitivity and specificity studies will establish normative and threshold values for impedance measurements that can be used as presumptive indicators of oedema. User friendly technology and equipment suitable for clinical use will be developed which should improve treatment therapies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454166
Funder
Australian Research Council
Funding Amount
$1,305,029.00
Summary
Nanoscale Materials Characterization Facility. We request a transmission and a scanning electron microscope, each with specialist electron probes smaller than a nanometre, which can selectively analyse the atomic structure and chemistry of sub-nanometre regions of material.
These capabilities are essential to advance a large range of research projects at the cutting-edge of materials science and engineering, undertaken by Victoria's leading research institutions: five Victorian universities, ....Nanoscale Materials Characterization Facility. We request a transmission and a scanning electron microscope, each with specialist electron probes smaller than a nanometre, which can selectively analyse the atomic structure and chemistry of sub-nanometre regions of material.
These capabilities are essential to advance a large range of research projects at the cutting-edge of materials science and engineering, undertaken by Victoria's leading research institutions: five Victorian universities, the CSIRO, Nanotechnology Victoria Ltd, the Victorian Centre for Advanced Materials Manufacturing and the CRC for Microtechnology. Together they have contributed $2.58 million to this project.
This state-of-the-art facility will include the highest spatial resolution microscope in Australia.
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Foundation studies of ion-beam nanotechnology. The impact of a single fast atom with sensitive materials leaves a path of latent damage with a diameter of around 10 nm. This latent damage can be developed to create nanostructures in a novel technique called ion beam nanomachining. We propose to create a method for using single atom impacts to produce nanomachined structures with novel physical and optical properties. This will be done by use of an active substrate that functions as a detector s ....Foundation studies of ion-beam nanotechnology. The impact of a single fast atom with sensitive materials leaves a path of latent damage with a diameter of around 10 nm. This latent damage can be developed to create nanostructures in a novel technique called ion beam nanomachining. We propose to create a method for using single atom impacts to produce nanomachined structures with novel physical and optical properties. This will be done by use of an active substrate that functions as a detector sensitive to single ion impacts. We propose to study the fundamental principles of this method.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775544
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
X-Ray Facility for 3-D High Resolution Diffraction Imaging of Nanostructures. Australian advances in quantitative x-ray imaging are at the leading edge of international efforts to permit 3D characterisation of the structure of materials and dynamic studies of structural changes. They have proven to be sensitive to local arrangement of materials at the nanometre scale, and they are emerging as critical tools in the development of advanced materials, which is a national research priority. This fac ....X-Ray Facility for 3-D High Resolution Diffraction Imaging of Nanostructures. Australian advances in quantitative x-ray imaging are at the leading edge of international efforts to permit 3D characterisation of the structure of materials and dynamic studies of structural changes. They have proven to be sensitive to local arrangement of materials at the nanometre scale, and they are emerging as critical tools in the development of advanced materials, which is a national research priority. This facility will allow the non-destructive 3D imaging of nanostructured materials to be performed as continual experimental development - something that is very difficult to achieve at synchrotron sources where access can be sporadic. The newly developed techniques will be applied to critical problems in emerging nanotechnologies.Read moreRead less
High-resolution electron diffraction imaging for the nanosciences. This project will develop new ways of seeing structure at the atomic level, to yield new imaging approaches needed for frontier developments in nano-science and nanotechnology. These areas are critical to Australia's future economic development and it is only through significant improvements in imaging capacity that we will be able to sustain this country's outstanding record in scientific innovation. The project will obtain inte ....High-resolution electron diffraction imaging for the nanosciences. This project will develop new ways of seeing structure at the atomic level, to yield new imaging approaches needed for frontier developments in nano-science and nanotechnology. These areas are critical to Australia's future economic development and it is only through significant improvements in imaging capacity that we will be able to sustain this country's outstanding record in scientific innovation. The project will obtain intellectual leverage from the expertise of the team of Chief Investigators, utilizing state-of-the-art infrastructure available in Australia and abroad, and provide a professional and broad training environment for our best and brightest graduate students.Read moreRead less
Swift Heavy Ion Tracks in Semiconductors and Insulators: New Insights using Synchrotron Scattering Experiments. The proposed research will broaden the domestic knowledge base and enhance the national research profile in an important cross-disciplinary and technologically-relevant field with a potential high impact in areas with considerable national activity. It will train young scientists, particularly in the use of two national facilities: the Australian Synchrotron and the ANU Heavy-Ion Accel ....Swift Heavy Ion Tracks in Semiconductors and Insulators: New Insights using Synchrotron Scattering Experiments. The proposed research will broaden the domestic knowledge base and enhance the national research profile in an important cross-disciplinary and technologically-relevant field with a potential high impact in areas with considerable national activity. It will train young scientists, particularly in the use of two national facilities: the Australian Synchrotron and the ANU Heavy-Ion Accelerator facility. Furthermore, domestic capabilities in materials characterization will be bolstered and the collaboration with overseas investigators will facilitate mutually beneficial transfer of expertise. The proposal is consistent with National Research Priority 3 and the Priority Goals: Breakthrough Science and Frontier Technologies. Read moreRead less
Scanning Probe Microscopy for Fabrication and Analysis of Polymer Photovoltaics. Australian economic growth will depend increasingly on the provision of devices using materials designed at the molecular level. Scanning probe microscopy, which uses tips placed very close to surfaces to analyse or modify the surfaces with molecular precision, is an indispensible tool in designing such materials. In this project, scanning probe microscopy will be used to analyse and build structures on polymer sola ....Scanning Probe Microscopy for Fabrication and Analysis of Polymer Photovoltaics. Australian economic growth will depend increasingly on the provision of devices using materials designed at the molecular level. Scanning probe microscopy, which uses tips placed very close to surfaces to analyse or modify the surfaces with molecular precision, is an indispensible tool in designing such materials. In this project, scanning probe microscopy will be used to analyse and build structures on polymer solar cells in order to maximise the efficiency of the cells and build prototype nanoscale polymer devices. This will lead to the improvement in devices delivering sustainable energy production - a technology which has the promise of producing energy cheaply from sunlight.Read moreRead less
High Resolution Imaging and Analysis of Embedded Interfaces and Interface Phase Transitions in Interface-Dominated Nanomaterials. Heterogeneous nanostructured materials and assemblies offer unique structure-property relationships, dominated by the internal interfaces they contain. This interdisciplinary research project will combine novel techniques based on high-resolution phase-retrieval x-ray diffraction and imaging, with complementary analytical electron microscopy and atom probe analysis, i ....High Resolution Imaging and Analysis of Embedded Interfaces and Interface Phase Transitions in Interface-Dominated Nanomaterials. Heterogeneous nanostructured materials and assemblies offer unique structure-property relationships, dominated by the internal interfaces they contain. This interdisciplinary research project will combine novel techniques based on high-resolution phase-retrieval x-ray diffraction and imaging, with complementary analytical electron microscopy and atom probe analysis, in a coordinated study of the structure and properties of embedded interfaces in strategic bi-crystals and nanostructures. It promises new techniques for the study of such defects, and a breakthrough in the understanding of the structural transitions that occur in embedded interfaces as a function of local changes in composition and temperature.Read moreRead less
New experimental-analytical x-ray diffraction technique for unambiguous non-destructive characterization of high-performance silicon-germanium-carbon alloys for broadband communication devices. This research will develop a new x-ray diffraction technique for characterization of silicon-germanium-carbon semiconductor alloys. These are the basis for the new generation, ultra-high speed broadband telecommunication devices. The research will establish a new theoretical methodology for fundamental st ....New experimental-analytical x-ray diffraction technique for unambiguous non-destructive characterization of high-performance silicon-germanium-carbon alloys for broadband communication devices. This research will develop a new x-ray diffraction technique for characterization of silicon-germanium-carbon semiconductor alloys. These are the basis for the new generation, ultra-high speed broadband telecommunication devices. The research will establish a new theoretical methodology for fundamental studies of x-ray scattering phenomena in compound strain-compensated materials. The experiments will be carried out using the state-of-the-art laboratory and synchrotron radiation facilities in Australia, Japan and France. The project involves direct collaboration with IHP Germany, the world-leading semiconductor developer. Highly qualified postgraduate students will be extensively trained in modern synchrotron experiments, x-ray diffraction theory and semiconductor technology during the project.Read moreRead less
Electron Tomography of Electromagnetic Fields, Potentials and Sources. The proliferation of technologies incorporating magnetic materials with exquisitely fine structure demands precise characterization methods, which are able to keep pace with magnetic miniaturization. However, existing techniques are unable to directly image magnetic materials at high resolution in three dimensions. We will overcome this deficiency, by combining an exciting new methodology for the three-dimensional visualisati ....Electron Tomography of Electromagnetic Fields, Potentials and Sources. The proliferation of technologies incorporating magnetic materials with exquisitely fine structure demands precise characterization methods, which are able to keep pace with magnetic miniaturization. However, existing techniques are unable to directly image magnetic materials at high resolution in three dimensions. We will overcome this deficiency, by combining an exciting new methodology for the three-dimensional visualisation of electromagnetic fields, with the latest cutting-edge electron-microscopes, thereby facilitating advances in magnetic nano-manufacturing. The anticipated applications are vast, from patterned nanomagnets and magnetic proteins, through to semiconductors and superconductors.Read moreRead less