The Role Of Stem-progenitor Cells In Regeneration Of Mouse Endometrium.
Funder
National Health and Medical Research Council
Funding Amount
$311,938.00
Summary
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Central Neural Circuits Subserving Nutrient–activated Thermogenesis - The Basis Of Post Prandial Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$766,207.00
Summary
Studies of “energy burning” brown fat, including its importance in the determination of obesity in humans and the potential to increase its capacity by turning white fat into brown-like fat are currently foremost in obesity research. Here we study the detail of brain pathways that dictate brown fat activity after a meal resulting in the burning of ingested calories and reduction of body weight. The results will give us a better idea of how we can harness brown fat to combat obesity.
Central Neural Regulation Of Brown Fat Function – Glucose Sensing And CNS Pathways
Funder
National Health and Medical Research Council
Funding Amount
$761,942.00
Summary
Our research aims to identify how specific brain cells detect changes in glucose levels and how ageing and diet affect their function. We identified a subset of nerve cells that detect changes in glucose and the “hunger” hormone ghrelin, their ability to do so adapting with age and nutritional status. This project will investigate the potential of these nerve cells as targets for therapeutic and diet- intervention strategies to target obesity, diabetes and promote healthy ageing.
Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitab ....Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitable for use in compact electrical devices requiring high current density. This project will add to the techniques used for the analysis of carbon coatings being developed in Australia. Read moreRead less
Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theo ....Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theoretical tools, in partnership with leading experimental groups, to enable the exploration of this technology and the creation of new and innovative applications which will have far reaching implications in all areas of society and significant national benefit.Read moreRead less
Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface ....Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface topography and generating movies of dynamic events. The development of new synchrotron based electron microscopy techniques will establish the expertise for the future creation of a dedicated nanotechnology beamline equipped with photo-emission electron microscopy which will have far reaching national benefit in the physical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less
Quantum Dot Self-Assembly via Langmuir Decomposition. We will develop a new capability to precisely position quantum structures on surfaces in large-scale patterns, solving a key problem in nanotechnology. We expect to generate patents governing key lithographic technology which will underpin the fabrication of the next generation of devices and we anticipate the generation of spin-off companies in this area. The ability to integrate new quantum structures into optoelectronics will impact everyd ....Quantum Dot Self-Assembly via Langmuir Decomposition. We will develop a new capability to precisely position quantum structures on surfaces in large-scale patterns, solving a key problem in nanotechnology. We expect to generate patents governing key lithographic technology which will underpin the fabrication of the next generation of devices and we anticipate the generation of spin-off companies in this area. The ability to integrate new quantum structures into optoelectronics will impact everyday life from communications and lighting to environmental sensing and medical care. The project will generate key expertise and high level training for post-doctoral fellows and post-graduate students in materials physics and nanotechnology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101157
Funder
Australian Research Council
Funding Amount
$384,276.00
Summary
Realisation of novel electronic phases in two-dimensional materials. This project will address one of the most pressing concerns facing society today, the efficient generation, storage, transmission and use of energy. Silicon based transistor technology is approaching the hard limit of efficiency set by thermodynamics, requiring new materials to be found that possess electronic properties that break away from conventional transistor technology. Utilising a new facility being installed by the app ....Realisation of novel electronic phases in two-dimensional materials. This project will address one of the most pressing concerns facing society today, the efficient generation, storage, transmission and use of energy. Silicon based transistor technology is approaching the hard limit of efficiency set by thermodynamics, requiring new materials to be found that possess electronic properties that break away from conventional transistor technology. Utilising a new facility being installed by the applicant at the Australian Synchrotron, this project aims to prepare and characterise the electronic properties of free-standing atomically thin bismuth. Successful realisation of this project will provide a radical new approach towards realising more efficient electronic devices for the storage and transmission of energy.Read moreRead less