The Role Of Stem-progenitor Cells In Regeneration Of Mouse Endometrium.
Funder
National Health and Medical Research Council
Funding Amount
$311,938.00
Summary
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Central Neural Circuits Subserving Nutrient–activated Thermogenesis - The Basis Of Post Prandial Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$766,207.00
Summary
Studies of “energy burning” brown fat, including its importance in the determination of obesity in humans and the potential to increase its capacity by turning white fat into brown-like fat are currently foremost in obesity research. Here we study the detail of brain pathways that dictate brown fat activity after a meal resulting in the burning of ingested calories and reduction of body weight. The results will give us a better idea of how we can harness brown fat to combat obesity.
Central Neural Regulation Of Brown Fat Function – Glucose Sensing And CNS Pathways
Funder
National Health and Medical Research Council
Funding Amount
$761,942.00
Summary
Our research aims to identify how specific brain cells detect changes in glucose levels and how ageing and diet affect their function. We identified a subset of nerve cells that detect changes in glucose and the “hunger” hormone ghrelin, their ability to do so adapting with age and nutritional status. This project will investigate the potential of these nerve cells as targets for therapeutic and diet- intervention strategies to target obesity, diabetes and promote healthy ageing.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitab ....Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitable for use in compact electrical devices requiring high current density. This project will add to the techniques used for the analysis of carbon coatings being developed in Australia. Read moreRead less
Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theo ....Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theoretical tools, in partnership with leading experimental groups, to enable the exploration of this technology and the creation of new and innovative applications which will have far reaching implications in all areas of society and significant national benefit.Read moreRead less
Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding proces ....Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding process in condensed matter systems and benchmark how these fault-tolerant quantum bits operate under real-world conditions. By providing the theory for advanced structures and devices, this project will inform experiments and pave the way for future technology based on topological phenomena.Read moreRead less
Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface ....Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface topography and generating movies of dynamic events. The development of new synchrotron based electron microscopy techniques will establish the expertise for the future creation of a dedicated nanotechnology beamline equipped with photo-emission electron microscopy which will have far reaching national benefit in the physical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less