Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Redesigning the transistor at the atomic-scale. Australian researchers have a world-wide leadership position in atomic-scale electronics. Through the development of powerful new fabrication technologies, Australian scientists are now poised to uncover the physical properties of electronic systems operating on the atomic-scale. This research will be internationally significant, providing ongoing international profile for Australian science. Perhaps more significantly, it will also lay the groundw ....Redesigning the transistor at the atomic-scale. Australian researchers have a world-wide leadership position in atomic-scale electronics. Through the development of powerful new fabrication technologies, Australian scientists are now poised to uncover the physical properties of electronic systems operating on the atomic-scale. This research will be internationally significant, providing ongoing international profile for Australian science. Perhaps more significantly, it will also lay the groundwork for future miniaturisation - and redesign - of the conventional transistor. Over the longer-term, it offers an opportunity for Australia to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454224
Funder
Australian Research Council
Funding Amount
$1,234,800.00
Summary
Scanning probe facility for atomic-scale device fabrication in silicon and its integration with molecular electronics. This application will establish a unique scanning probe facility to launch two major new initiatives in electronic device fabrication in Australia: (i) atomic-scale device fabrication in silicon and (ii) the integration with molecular electronics. The revolutionary features of the Nanoprobe system exploits recent advances in scanning probe techniques to allow for the first time ....Scanning probe facility for atomic-scale device fabrication in silicon and its integration with molecular electronics. This application will establish a unique scanning probe facility to launch two major new initiatives in electronic device fabrication in Australia: (i) atomic-scale device fabrication in silicon and (ii) the integration with molecular electronics. The revolutionary features of the Nanoprobe system exploits recent advances in scanning probe techniques to allow for the first time fully functional silicon and hybrid silicon-molecular electronic devices to be fabricated and tested at the atomic-scale. Such a facility will draw together a host of experienced researchers in this emerging field enabling Australia to actively lead the development of this new technology at its early stages.Read moreRead less
Fundamental conduction mechanisms in atomic-scale silicon devices. This proposal will ensure that Australia remains at the forefront of worldwide research into atomic-scale electronics. It links leading nanotechnologists from Canada and Italy to a dynamic and growing Australian team, which already has strong collaborations with researchers in the UK, the US, Japan, and Taiwan. In the long-run, Australia stands to benefit indirectly from the research as it is a significant user of semiconductors ....Fundamental conduction mechanisms in atomic-scale silicon devices. This proposal will ensure that Australia remains at the forefront of worldwide research into atomic-scale electronics. It links leading nanotechnologists from Canada and Italy to a dynamic and growing Australian team, which already has strong collaborations with researchers in the UK, the US, Japan, and Taiwan. In the long-run, Australia stands to benefit indirectly from the research as it is a significant user of semiconductors across all major industries. More importantly, by anticipating the problems that electronic device manufacturers will face over their long-term horizons, the proposed research also seeks to provide Australia with a chance to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Atomic-scale Devices in Silicon - the Ultimate Limit of Microelectronics. Miniaturisation is the driving force behind the microelectronics industry, but beyond 2015 there is no known route to reduce device sizes below 10nm. The Fellowship will launch a major new initiative for the fabrication of silicon electronic devices at the atomic-scale (0.1nm). The project will exploit recent advances in scanning probe techniques to develop smaller and faster conventional transistors, nanoscale integrated ....Atomic-scale Devices in Silicon - the Ultimate Limit of Microelectronics. Miniaturisation is the driving force behind the microelectronics industry, but beyond 2015 there is no known route to reduce device sizes below 10nm. The Fellowship will launch a major new initiative for the fabrication of silicon electronic devices at the atomic-scale (0.1nm). The project will exploit recent advances in scanning probe techniques to develop smaller and faster conventional transistors, nanoscale integrated circuits, and address device reproducibility at this scale. This will extend Australia's early lead in atomic-scale silicon electronics to the stage where interested industry partners can evaluate it commercially in a way that will maximise benefits to Australia.Read moreRead less
Three Dimensional Integrated Circuits. Pushing the boundaries of current silicon fabrication technology, this proposal will investigate the possibilities of new 3D architectures to ensure that Australia remains at the forefront of world-wide research into atomic-scale electronics. It creates an important link to the latest technologies in atomistic device modelling in the US, developed at Texas Instruments. More importantly, by anticipating the problems that electronic device manufacturers are c ....Three Dimensional Integrated Circuits. Pushing the boundaries of current silicon fabrication technology, this proposal will investigate the possibilities of new 3D architectures to ensure that Australia remains at the forefront of world-wide research into atomic-scale electronics. It creates an important link to the latest technologies in atomistic device modelling in the US, developed at Texas Instruments. More importantly, by anticipating the problems that electronic device manufacturers are currently facing, and will face over their long-term horizons, the proposed research also seeks to provide Australia with a chance to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Atomic Electronics: Precompetitive Research for the Global Semiconductor Industry. The demonstration in Australia that electronic devices in silicon can be fabricated at the atomic-scale has provided a vision for global semiconductor manufacturers. By engaging with leading US companies to tackle the problems industry faces as it attempts to reach this scale, this Fellowship will ensure that Australia remains at the forefront of growing world-wide research into atomic-scale electronics. Equally ....Atomic Electronics: Precompetitive Research for the Global Semiconductor Industry. The demonstration in Australia that electronic devices in silicon can be fabricated at the atomic-scale has provided a vision for global semiconductor manufacturers. By engaging with leading US companies to tackle the problems industry faces as it attempts to reach this scale, this Fellowship will ensure that Australia remains at the forefront of growing world-wide research into atomic-scale electronics. Equally important, by anticipating the problems that electronic device manufacturers are currently facing, and will face over their long-term horizons, the proposed research seeks to provide Australia with a long-term opportunity to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Insight and understanding in Rare-Earth magnetism. Today's technologically driven society relies on magnetic materials to an extent unimaginable even as recently as 20 years ago. Rare-earth transition-metal intermetallics are among the most important magnetic materials, providing the World's strongest magnet with extensive applications. Despite these impressive technological and commercial developments numerous aspects of rare-earth magnetism remain to be developed and resolved. The two innovati ....Insight and understanding in Rare-Earth magnetism. Today's technologically driven society relies on magnetic materials to an extent unimaginable even as recently as 20 years ago. Rare-earth transition-metal intermetallics are among the most important magnetic materials, providing the World's strongest magnet with extensive applications. Despite these impressive technological and commercial developments numerous aspects of rare-earth magnetism remain to be developed and resolved. The two innovative topics we shall research are the critical interplay between the rare-earth and transition-metal sublattices in ternary compounds, enabling us to understand complex compounds, and exploration of a set of quaternary compounds we have recently discovered, thus opening new areas of rare-earth magnetism.Read moreRead less
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.