We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Nanoclusters with Extraordinary Properties Made out of Ordinary Materials. Ultrafast laser deposition - a process pioneered by the Applicants - has already demonstrated record yields in the production of carbon-based nano-clustered materials with better control over the size of the nano-particles than any other process. This project aims to improve fundamental understanding of the ultra-fast laser deposition method of nano-fabrication through theoretical and experimental studies, which accurate ....Nanoclusters with Extraordinary Properties Made out of Ordinary Materials. Ultrafast laser deposition - a process pioneered by the Applicants - has already demonstrated record yields in the production of carbon-based nano-clustered materials with better control over the size of the nano-particles than any other process. This project aims to improve fundamental understanding of the ultra-fast laser deposition method of nano-fabrication through theoretical and experimental studies, which accurately correlate the ablation conditions to the structural, electronic, magnetic and optical properties of resulting nano-particles. The results will be applied to efficiently produce nano-clustered materials with tuneable properties for a wide range of new technologies such as spintronics, biophotonics, and nanoclinics.Read moreRead less
High-energy electron scattering of surfaces: new spectroscopies and new physics. Electrons sometimes behave as particles, and sometimes as waves. Both aspects are used when investigating nano-structures with electron beams. In this research program we design and perform experiments to measure sample composition using the particle nature, and the atom positions by using the wave nature of electrons. These novel experiments, using unique spectrometers designed and developed in Australia, are aime ....High-energy electron scattering of surfaces: new spectroscopies and new physics. Electrons sometimes behave as particles, and sometimes as waves. Both aspects are used when investigating nano-structures with electron beams. In this research program we design and perform experiments to measure sample composition using the particle nature, and the atom positions by using the wave nature of electrons. These novel experiments, using unique spectrometers designed and developed in Australia, are aimed at making new forms of electron microscopy possible, but will also result in a better understanding of existing electron microscopies and synchrotron-based measurements.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668302
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Floating-zone Crystal Growth Facility. Optical floating-zone furnaces are powerful and efficient tools for the discovery and characterisation of new materials. They are widely used in the solid-state chemistry, condensed-matter physics, materials science, and engineering communities. This optical floating-zone furnace, the first in Australia, will support and encourage the growing number of local researchers in these fields. It will allow them to take much better advantage of the new research re ....Floating-zone Crystal Growth Facility. Optical floating-zone furnaces are powerful and efficient tools for the discovery and characterisation of new materials. They are widely used in the solid-state chemistry, condensed-matter physics, materials science, and engineering communities. This optical floating-zone furnace, the first in Australia, will support and encourage the growing number of local researchers in these fields. It will allow them to take much better advantage of the new research reactor and synchrotron being constructed in Australia by maximising their ability to grow crystals of technologically and scientifically important materials, particularly electronic and magnetic materials, for fundamental and applied research at those facilities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less
Formation of nanocrystals (or nanocrystals with core/shell structure) and applications for photonics, floating gate and magnetic memory. Materials that contain nanometre-sized crystallites of a second material can exhibit novel optical, electrical and magnetic properties that have direct technological application. However, it is often difficult to control the size and concentration of the small crystals using conventional synthesis techniques. This project will overcome these limitations by ex ....Formation of nanocrystals (or nanocrystals with core/shell structure) and applications for photonics, floating gate and magnetic memory. Materials that contain nanometre-sized crystallites of a second material can exhibit novel optical, electrical and magnetic properties that have direct technological application. However, it is often difficult to control the size and concentration of the small crystals using conventional synthesis techniques. This project will overcome these limitations by exploiting the unique properties of pulsed-laser heating to produce the crystals. It will also investigate the optical, electrical and magnetic properties of these new materials and asses their suitability for super-dense data storage, solid-state lighting and advanced detection systems.Read moreRead less
Switching mechanisms in nonvolatile resistive memory using high-k dielectrics. Growth in the use of portable electronic devices, such as cameras, phones and MP3 players has resulted in an increased demand for low-power, high-density, non-volatile memory (NVM). One class of such memories aims to use resistance changes in thin dielectric films as a means of storing information. This project aims to develop a better understanding of these devices and to develop new and innovative processes for co ....Switching mechanisms in nonvolatile resistive memory using high-k dielectrics. Growth in the use of portable electronic devices, such as cameras, phones and MP3 players has resulted in an increased demand for low-power, high-density, non-volatile memory (NVM). One class of such memories aims to use resistance changes in thin dielectric films as a means of storing information. This project aims to develop a better understanding of these devices and to develop new and innovative processes for controlling data storage. The project is based on collaboration between researchers at the ANU and Silanna, an Australian start-up company aiming to develop and commercialise such technology.Read moreRead less
Applying advanced synchrotron radiation-based techniques to determine the connection between the geometric and electronic structure of semiconductor nanocrystals. As the dimensions of nanocrystals become small unique optical and electronic properties are observed, forming the basis of many new technologies. The properties of interest depend on the fine-scale, local details of the nanocrystal structure, which may differ considerably from bulk-like. Advanced synchrotron radiation techniques wil ....Applying advanced synchrotron radiation-based techniques to determine the connection between the geometric and electronic structure of semiconductor nanocrystals. As the dimensions of nanocrystals become small unique optical and electronic properties are observed, forming the basis of many new technologies. The properties of interest depend on the fine-scale, local details of the nanocrystal structure, which may differ considerably from bulk-like. Advanced synchrotron radiation techniques will be used to investigate the relationship between the local geometric and electronic structure of semiconductor nanocrystals. Insight will be provided to their formation and stability, and the important mechanisms of their unique optical and electronic properties will be identified. Such fundamental information is necessary to facilitate innovative application of future nanocrystal technology.Read moreRead less
ARC Centre of Excellence in Exciton Science. This Centre aims to manipulate the way light energy is absorbed, transported and transformed in advanced molecular materials. The research programme spans high-throughput computational screening, single molecule photochemistry and ultrafast spectroscopy and embraces innovative outreach and commercial translation activities. The Centre plans to capture the knowledge generated as new intellectual property, materials processing know-how, and through the ....ARC Centre of Excellence in Exciton Science. This Centre aims to manipulate the way light energy is absorbed, transported and transformed in advanced molecular materials. The research programme spans high-throughput computational screening, single molecule photochemistry and ultrafast spectroscopy and embraces innovative outreach and commercial translation activities. The Centre plans to capture the knowledge generated as new intellectual property, materials processing know-how, and through the creation of new employment opportunities. The expected outcomes and benefits include new Australian technologies in solar energy conversion, energy-efficient lighting and displays, security labelling and optical sensor platforms for defence.Read moreRead less
Charge transport and trapping in high-k dielectric films containing self-assembled nanocrystals. Growth in the use of portable electronic devices such as mobile phones, iPods, MP3-players and personal digital assistants (PDA's) has resulted in increased demand for low-power, high-density Flash memory. However, existing memory devices are difficult to scale to smaller dimensions and lower power without severely compromising reliability. This project will investigate the synthesis and properties ....Charge transport and trapping in high-k dielectric films containing self-assembled nanocrystals. Growth in the use of portable electronic devices such as mobile phones, iPods, MP3-players and personal digital assistants (PDA's) has resulted in increased demand for low-power, high-density Flash memory. However, existing memory devices are difficult to scale to smaller dimensions and lower power without severely compromising reliability. This project will investigate the synthesis and properties of a new class of materials that have the potential to overcome these limitations. Read moreRead less