We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668302
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Floating-zone Crystal Growth Facility. Optical floating-zone furnaces are powerful and efficient tools for the discovery and characterisation of new materials. They are widely used in the solid-state chemistry, condensed-matter physics, materials science, and engineering communities. This optical floating-zone furnace, the first in Australia, will support and encourage the growing number of local researchers in these fields. It will allow them to take much better advantage of the new research re ....Floating-zone Crystal Growth Facility. Optical floating-zone furnaces are powerful and efficient tools for the discovery and characterisation of new materials. They are widely used in the solid-state chemistry, condensed-matter physics, materials science, and engineering communities. This optical floating-zone furnace, the first in Australia, will support and encourage the growing number of local researchers in these fields. It will allow them to take much better advantage of the new research reactor and synchrotron being constructed in Australia by maximising their ability to grow crystals of technologically and scientifically important materials, particularly electronic and magnetic materials, for fundamental and applied research at those facilities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883095
Funder
Australian Research Council
Funding Amount
$750,000.00
Summary
Integrated Surface Fabrication and Characterisation Laboratory. New electronic devices and materials that exploit the properties of polymers and organic molecules are predicted to have a major impact on everyday life in areas such as photovoltaics, biotechnology and healthcare. The IntLAB facility will provide researchers for the first time with the unique capability of building and characterising complex multi-layered thin films of polymers and organic molecules completely under controlled envi ....Integrated Surface Fabrication and Characterisation Laboratory. New electronic devices and materials that exploit the properties of polymers and organic molecules are predicted to have a major impact on everyday life in areas such as photovoltaics, biotechnology and healthcare. The IntLAB facility will provide researchers for the first time with the unique capability of building and characterising complex multi-layered thin films of polymers and organic molecules completely under controlled environments. The IntLAB represents a major new joint venture between three major Australian Universities, CSIRO and ANSTO and will provide researchers with the essential tools for developing new electronic devices, biosensors, detectors and solar cells based on nanotechnology.Read moreRead less
Synchrotron radiation techniques applied to melting and resolidification at a nanometric scale. By delivering underpinning knowledge of melting characteristics of nanoparticles, the proposal seeks results that can lead to breakthrough applications in advanced materials engineering. Measurements of the liquid nanoparticle structure performed at the Australian Synchrotron are unprecedented and are thus likely to include the development of new methodology. National and international exposure of Aus ....Synchrotron radiation techniques applied to melting and resolidification at a nanometric scale. By delivering underpinning knowledge of melting characteristics of nanoparticles, the proposal seeks results that can lead to breakthrough applications in advanced materials engineering. Measurements of the liquid nanoparticle structure performed at the Australian Synchrotron are unprecedented and are thus likely to include the development of new methodology. National and international exposure of Australian science and the Australian Synchrotron will have both scientific and economic ramifications. Involvement of students will contribute to developing the local synchrotron knowledge base and is beneficial to the Australian synchrotron-research community as a whole.Read moreRead less
Tailoring superconducting hybrid multilayered film systems for electric and electronic applications. This project focuses on the development of new scientific and technological aspects of the fabrication, properties and operation of novel hybrid systems for revolutionizing electricity handling and electronics. It will also solve some existing problems of film structures with promising multilayer technology. Hybrid systems, often make the headlines in science and are gaining an increasingly promi ....Tailoring superconducting hybrid multilayered film systems for electric and electronic applications. This project focuses on the development of new scientific and technological aspects of the fabrication, properties and operation of novel hybrid systems for revolutionizing electricity handling and electronics. It will also solve some existing problems of film structures with promising multilayer technology. Hybrid systems, often make the headlines in science and are gaining an increasingly promising outlook in materials engineering, nanotechnology and electronics, promising eventual application in a broad range of industries. This project will establish Australia's capability at the forefront in this area. The outcomes predicted will benefit existing Australian companies and may establish new companies dealing with these hybrid systems.Read moreRead less
A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100235
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Interfacial mapping facility. New electronic materials and devices impact on everyday life in areas such as photovoltaics, biotechnology and healthcare. This facility will provide researchers with the unique capability of mapping both the structure and electronic properties of materials on the nanoscale. It will be an essential tool for developing new electronics based on nanotechnology.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453426
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australi ....Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australia's partnership with the world's most intense neutron source, ISIS in the UK, in order to sustain the considerable Australian scientific momentum which now relies on ISIS.
The outcomes will be new science that cannot be generated solely within Australia.
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