To Repair An Osteo-chondral Defect In An Experimental Rabbit Model Using A Structured 3D Nano-composite Scaffold Loaded With Mesenchymal Stem Cells (MSC)
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
The treatment of cartilage damage is a major problem in orthopaedic practice. The use of a 3D scaffold may overcome many challenges associated with cartilage and bone repair and regeneration. The aim of this research is to culture bone and cartilage cells into a prefabricated scaffold which may then be tested in an animal model. The results of this research may offer a new method of treating post-traumatic and osteoarthritic defects.
Manipulating The Anabolic And Catabolic Responses For Bone Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$58,202.00
Summary
The repair of large bone defects represents a significant clinical problem. Evolving tissue engineering technologies may lead to significant improvements in orthopaedic treatments for these problems. We plan to compare novel biological approaches designed to maximise new bone formation while preventing bone resorption with existing synthetic graft materials. Our research data will be readily translated from the laboratory to a clinical setting.