Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
The Role Of Stem-progenitor Cells In Regeneration Of Mouse Endometrium.
Funder
National Health and Medical Research Council
Funding Amount
$311,938.00
Summary
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Central Neural Circuits Subserving Nutrient–activated Thermogenesis - The Basis Of Post Prandial Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$766,207.00
Summary
Studies of “energy burning” brown fat, including its importance in the determination of obesity in humans and the potential to increase its capacity by turning white fat into brown-like fat are currently foremost in obesity research. Here we study the detail of brain pathways that dictate brown fat activity after a meal resulting in the burning of ingested calories and reduction of body weight. The results will give us a better idea of how we can harness brown fat to combat obesity.
Redesigning the transistor at the atomic-scale. Australian researchers have a world-wide leadership position in atomic-scale electronics. Through the development of powerful new fabrication technologies, Australian scientists are now poised to uncover the physical properties of electronic systems operating on the atomic-scale. This research will be internationally significant, providing ongoing international profile for Australian science. Perhaps more significantly, it will also lay the groundw ....Redesigning the transistor at the atomic-scale. Australian researchers have a world-wide leadership position in atomic-scale electronics. Through the development of powerful new fabrication technologies, Australian scientists are now poised to uncover the physical properties of electronic systems operating on the atomic-scale. This research will be internationally significant, providing ongoing international profile for Australian science. Perhaps more significantly, it will also lay the groundwork for future miniaturisation - and redesign - of the conventional transistor. Over the longer-term, it offers an opportunity for Australia to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454224
Funder
Australian Research Council
Funding Amount
$1,234,800.00
Summary
Scanning probe facility for atomic-scale device fabrication in silicon and its integration with molecular electronics. This application will establish a unique scanning probe facility to launch two major new initiatives in electronic device fabrication in Australia: (i) atomic-scale device fabrication in silicon and (ii) the integration with molecular electronics. The revolutionary features of the Nanoprobe system exploits recent advances in scanning probe techniques to allow for the first time ....Scanning probe facility for atomic-scale device fabrication in silicon and its integration with molecular electronics. This application will establish a unique scanning probe facility to launch two major new initiatives in electronic device fabrication in Australia: (i) atomic-scale device fabrication in silicon and (ii) the integration with molecular electronics. The revolutionary features of the Nanoprobe system exploits recent advances in scanning probe techniques to allow for the first time fully functional silicon and hybrid silicon-molecular electronic devices to be fabricated and tested at the atomic-scale. Such a facility will draw together a host of experienced researchers in this emerging field enabling Australia to actively lead the development of this new technology at its early stages.Read moreRead less
Fundamental conduction mechanisms in atomic-scale silicon devices. This proposal will ensure that Australia remains at the forefront of worldwide research into atomic-scale electronics. It links leading nanotechnologists from Canada and Italy to a dynamic and growing Australian team, which already has strong collaborations with researchers in the UK, the US, Japan, and Taiwan. In the long-run, Australia stands to benefit indirectly from the research as it is a significant user of semiconductors ....Fundamental conduction mechanisms in atomic-scale silicon devices. This proposal will ensure that Australia remains at the forefront of worldwide research into atomic-scale electronics. It links leading nanotechnologists from Canada and Italy to a dynamic and growing Australian team, which already has strong collaborations with researchers in the UK, the US, Japan, and Taiwan. In the long-run, Australia stands to benefit indirectly from the research as it is a significant user of semiconductors across all major industries. More importantly, by anticipating the problems that electronic device manufacturers will face over their long-term horizons, the proposed research also seeks to provide Australia with a chance to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Atomic-scale Devices in Silicon - the Ultimate Limit of Microelectronics. Miniaturisation is the driving force behind the microelectronics industry, but beyond 2015 there is no known route to reduce device sizes below 10nm. The Fellowship will launch a major new initiative for the fabrication of silicon electronic devices at the atomic-scale (0.1nm). The project will exploit recent advances in scanning probe techniques to develop smaller and faster conventional transistors, nanoscale integrated ....Atomic-scale Devices in Silicon - the Ultimate Limit of Microelectronics. Miniaturisation is the driving force behind the microelectronics industry, but beyond 2015 there is no known route to reduce device sizes below 10nm. The Fellowship will launch a major new initiative for the fabrication of silicon electronic devices at the atomic-scale (0.1nm). The project will exploit recent advances in scanning probe techniques to develop smaller and faster conventional transistors, nanoscale integrated circuits, and address device reproducibility at this scale. This will extend Australia's early lead in atomic-scale silicon electronics to the stage where interested industry partners can evaluate it commercially in a way that will maximise benefits to Australia.Read moreRead less
Ensuring The Utility And Sustainability Of Tissue Banks: Supporting Translational Research In Australia Through Informed Regulation And Community Engagement.
Funder
National Health and Medical Research Council
Funding Amount
$481,885.00
Summary
Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulati ....Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulation and deliver better health care systems.Read moreRead less