Epidemiology of Phoma spp. complex and other foliar pathogens affecting pyrethrum. We will quantify the spectrum of fungal plant pathogens found on pyrethrum (Tanacetum cineariifolium L.) foliage and their relative impact on yield and pyrethrin assay. For those fungi having a significant impact on production (such as Phoma ligulicola) we will conduct detailed epidemiological studies to determine how disease levels change with environmental parameters and geographical factors. This study will a ....Epidemiology of Phoma spp. complex and other foliar pathogens affecting pyrethrum. We will quantify the spectrum of fungal plant pathogens found on pyrethrum (Tanacetum cineariifolium L.) foliage and their relative impact on yield and pyrethrin assay. For those fungi having a significant impact on production (such as Phoma ligulicola) we will conduct detailed epidemiological studies to determine how disease levels change with environmental parameters and geographical factors. This study will adapt radiometric technology for disease assessment in pyrethrum, and develop predictive models for disease development based on environmental conditions and furthermore, assess the effect of simulated climate change events on disease severity in the future.Read moreRead less
Towards a durable management strategy for ray blight in Tasmanian pyrethrum crops. This project will take a multi-factorial approach to the identification of edaphic factors and their collinearity for the prediction of foliar disease caused by the fungus, Phoma ligulicola in Tasmanian pyrethrum crops. This will allow implementation of a decision support system whereby disease management options may be weighed against site specific risk. Alternative management strategies to the current fungicid ....Towards a durable management strategy for ray blight in Tasmanian pyrethrum crops. This project will take a multi-factorial approach to the identification of edaphic factors and their collinearity for the prediction of foliar disease caused by the fungus, Phoma ligulicola in Tasmanian pyrethrum crops. This will allow implementation of a decision support system whereby disease management options may be weighed against site specific risk. Alternative management strategies to the current fungicide based system for control will also be assessed for their efficacy and role in mitigating site risk. The effect of cultural control methods such as cultivar mixtures and host resistance will be modelled on the spatio-temporal characteristics of the epidemic and compared to these in naturally occurring epidemics at specific sites.Read moreRead less
Understanding the evolution of fungicide resistance for durable control of fungal pathogens in pyrethrum. The pyrethrum plant is grown for the extraction of natural insecticidal pyrethrins used in a variety of pest control products. Australia supplies 60 per cent of the global market for natural pyrethrins. Fungal pathogens of pyrethrum can cause severe losses. This project will investigate fungicide resistance in these pathogens at the molecular level.
Ensuring The Utility And Sustainability Of Tissue Banks: Supporting Translational Research In Australia Through Informed Regulation And Community Engagement.
Funder
National Health and Medical Research Council
Funding Amount
$481,885.00
Summary
Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulati ....Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulation and deliver better health care systems.Read moreRead less
An immunological and immunogenetic approach to understand and to protect Tasmanian devils against Devil Facial Tumour Disease. The Tasmanian devil is the world's largest living carnivorous marsupial. From an environmental perspective, devils play a fundamental role through scavenging. Dead and dying animals were removed nightly from Tasmania's landscape and therefore decaying carcases did not require removal. Loss of this top order scavenger will alter the balance of biodiversity and non-native ....An immunological and immunogenetic approach to understand and to protect Tasmanian devils against Devil Facial Tumour Disease. The Tasmanian devil is the world's largest living carnivorous marsupial. From an environmental perspective, devils play a fundamental role through scavenging. Dead and dying animals were removed nightly from Tasmania's landscape and therefore decaying carcases did not require removal. Loss of this top order scavenger will alter the balance of biodiversity and non-native animals (such as foxes, feral cats, crows, and even European wasps) will then compete for this scavenger role. As these animals are non-selective they will also prey on living animals and many of Tasmania's native animals (such as Eastern barred bandicoot, potoroos, quolls etc.) will be seriously threatened and our biodiverse landscape could be irreversibly altered.Read moreRead less
Meeting the challenges of Sclerotinia crown rot in a perennial production system - pyrethrum. The Australian pyrethrum industry has undergone rapid growth in the last decade, which has seen it become the second largest producer of natural insecticidal pyrethrins in the world. Current production supplies 60% of the global market, with further expansion planned. Sclerotinia crown rot is a major disease that results in plant death; reducing yields and the life of the perennial crop. This project ....Meeting the challenges of Sclerotinia crown rot in a perennial production system - pyrethrum. The Australian pyrethrum industry has undergone rapid growth in the last decade, which has seen it become the second largest producer of natural insecticidal pyrethrins in the world. Current production supplies 60% of the global market, with further expansion planned. Sclerotinia crown rot is a major disease that results in plant death; reducing yields and the life of the perennial crop. This project aims to develop more cost effective and environmentally sustainable methods of managing this disease. This will help to ensure consistent supply of pyrethrin to the world market, reduce the costs of production and increase the net return to growers.Read moreRead less
Integrated biological control of Sclerotinia minor root rot of pyrethrum crops. Tasmania is a major global supplier of natural pyrethrum, producing 25% of the world's requirements. However the industry has a major problem with Sclerotinia minor, current chemical treatment being expensive and providing limited effectiveness. The aim of this project is to develop long term integrated control measures for this disease, particularly by the application of biological control agents targeting S. minor ....Integrated biological control of Sclerotinia minor root rot of pyrethrum crops. Tasmania is a major global supplier of natural pyrethrum, producing 25% of the world's requirements. However the industry has a major problem with Sclerotinia minor, current chemical treatment being expensive and providing limited effectiveness. The aim of this project is to develop long term integrated control measures for this disease, particularly by the application of biological control agents targeting S. minor at planting. It will also examine possible break-crops biocidal to the fungus, and other integrated control measures. The significance/outcomes will be improved crop productivity to the industry, improved competitiveness with overseas producers and reduced dependence on chemical pesticides.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less