Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanism ....Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanisms for large scale stem cell differentiation. The expected outcomes are a significant advancement in knowledge in the field of tissue engineering and more efficient methodology for patient-derived stem cell therapy. This will provide new pathways to improving stem cell therapy for tissue engineering applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101755
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Regulation of cell reprogramming to pluripotency by complex topographies. This project aims to use nanotopography approaches to improve the efficiency of generating induced Pluripotent Stem Cells (iPSCs) by changing cell behaviour at biomaterial surfaces. The significance is that iPSCs have enormous potential in stem cell therapy, regenerative medicine, and disease-specific treatment, with the potential to replace other stem cell types. The expected outcomes are that cellular reprogramming proce ....Regulation of cell reprogramming to pluripotency by complex topographies. This project aims to use nanotopography approaches to improve the efficiency of generating induced Pluripotent Stem Cells (iPSCs) by changing cell behaviour at biomaterial surfaces. The significance is that iPSCs have enormous potential in stem cell therapy, regenerative medicine, and disease-specific treatment, with the potential to replace other stem cell types. The expected outcomes are that cellular reprogramming process for iPSCs generation will be improved and the canonical reprogramming factors might be reduced using surface nanotopographies of self-assembled colloidal crystals. The benefits are the promotion of productivity, the reduction of costs, and the application of iPSC derivatives, aimed at future clinical applications.Read moreRead less
Nanoparticle regulation of DNA replication and repair pathways. This project aims to understand how physical and chemical properties of nanoparticles influence how cells respond with respect to maintenance of their DNA integrity. It will use an innovative set of cross-disciplinary methodologies to link what nanoparticle parameters can lead to a benign fate in the environment. The project expects to generate new knowledge of how our ecosystem can be fundamentally impacted by nanoscale materials. ....Nanoparticle regulation of DNA replication and repair pathways. This project aims to understand how physical and chemical properties of nanoparticles influence how cells respond with respect to maintenance of their DNA integrity. It will use an innovative set of cross-disciplinary methodologies to link what nanoparticle parameters can lead to a benign fate in the environment. The project expects to generate new knowledge of how our ecosystem can be fundamentally impacted by nanoscale materials. The intended outcome of the project is to position Australia as a world leader in the manufacture of environmentally benign, advanced nano-scale materials. This is expected to provide economic benefits for Australian manufacturing while ensuring preservation of environmental health.Read moreRead less