Ensuring The Utility And Sustainability Of Tissue Banks: Supporting Translational Research In Australia Through Informed Regulation And Community Engagement.
Funder
National Health and Medical Research Council
Funding Amount
$481,885.00
Summary
Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulati ....Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulation and deliver better health care systems.Read moreRead less
Submarine explosive eruptions of silicic magma: constraints on products and processes from modern sea-floor examples, ancient successions and experiments. Volcanoes are common on the sea-floor. Many have been the sites of devastating explosive eruptions throughout Earth history, producing thick layers of pumice and volcanic ash in both modern and ancient ocean basins. None of these events has been witnessed, hence, little is known about submarine explosive eruptions and the associated volcanoes. ....Submarine explosive eruptions of silicic magma: constraints on products and processes from modern sea-floor examples, ancient successions and experiments. Volcanoes are common on the sea-floor. Many have been the sites of devastating explosive eruptions throughout Earth history, producing thick layers of pumice and volcanic ash in both modern and ancient ocean basins. None of these events has been witnessed, hence, little is known about submarine explosive eruptions and the associated volcanoes. This detailed, multidisciplinary study will link exploration of modern explosive sea-floor volcanoes (western Pacific Ocean), field-work on older, submarine volcanic formations (Japan, Greece) and experiments that simulate explosive eruptions and their products. The results will elucidate sea-floor explosive volcanism and its contribution to the geology of ocean basins.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100094
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, mate ....Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, materials testing, biomechanics and human factors, blast and earthquake simulations, field robotics, automotive safety research, flight/vehicle simulation, and marine applications including sloshing of liquids and liquefaction of fines. In conjunction with a 3D laser doppler system this facility will be unique in the world for dynamic mechanical testing.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
The novel production and analysis of breaking waves utilising circular-track moving disturbances. Surfing is a major industry in Australia, contributing $11billion to the economy. It has high active participation levels; but locations with good surfing conditions are limited and becoming crowded. New technologies, such as the circular-track wave pool, are required to provide safe environments for surfing with controllable high quality waves. The research in this proposal will considerably advanc ....The novel production and analysis of breaking waves utilising circular-track moving disturbances. Surfing is a major industry in Australia, contributing $11billion to the economy. It has high active participation levels; but locations with good surfing conditions are limited and becoming crowded. New technologies, such as the circular-track wave pool, are required to provide safe environments for surfing with controllable high quality waves. The research in this proposal will considerably advance knowledge of wave mechanics; provide the ability to design a commercially-viable wave pool and ensure the Australian surfing industry and sport continue to expand. The project will thus result in major scientific, economic and social benefits for Australia.Read moreRead less
Outflows, Jets and Plumes. This project studies how fluid flows out from a small concentrated object into a second surrounding fluid. New solution methods will be provided, and new results about how these fluid flows evolve will be obtained. These are important problems with significance in modelling underwater explosions. They are also important in astrophysics, and will help explain the shapes of outflows from some stars or galaxies. The outcomes of the project will be a deeper mathematical un ....Outflows, Jets and Plumes. This project studies how fluid flows out from a small concentrated object into a second surrounding fluid. New solution methods will be provided, and new results about how these fluid flows evolve will be obtained. These are important problems with significance in modelling underwater explosions. They are also important in astrophysics, and will help explain the shapes of outflows from some stars or galaxies. The outcomes of the project will be a deeper mathematical understanding of which outflow shapes are stable, and under what circumstances they might become unstable. This will provide valuable information about galaxy shapes, and a new suite of computational methods for solving such problems.Read moreRead less
Mathematical and computational analysis of ship wakes. This project aims to develop mathematical and computational tools to compute the energy in a given ship wake and to determine a range of properties of a ship by taking simple measurements of the water height as the ship travels past. The expected outcomes of this project include a suite of algorithms that back-calculate the hull shape and operating conditions of a moving ship given only the surface height data measured at a single point. The ....Mathematical and computational analysis of ship wakes. This project aims to develop mathematical and computational tools to compute the energy in a given ship wake and to determine a range of properties of a ship by taking simple measurements of the water height as the ship travels past. The expected outcomes of this project include a suite of algorithms that back-calculate the hull shape and operating conditions of a moving ship given only the surface height data measured at a single point. These results should have direct implications for measuring damage to coastal zones by ship wakes and for surveillance of shipping channels.Read moreRead less
Rapid starting and unsteady operation of hydraulic turbines. The project will investigate the ability of hydraulic turbines to start rapidly with the turbine spinning in air which is more water efficient and has lower maintenance costs than other methods. The project will allow higher use of hydroelectricity and higher penetration of wind or other intermittent renewable energy generation into an electricity grid.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less