Detection and elimination of resting spores of Olpidium vectoring lettuce big-vein disease in lettuce seedling nursery production. This project will devise nucleic acid and serology methods for detection of Olpidium brassicae, vector of lettuce big-vein disease (LBVD), during various phases of lettuce seedling production in nursery environments. It will be the first study to develop sustainable and environmentally responsible nursery best-practice protocols for integrated management of O. brass ....Detection and elimination of resting spores of Olpidium vectoring lettuce big-vein disease in lettuce seedling nursery production. This project will devise nucleic acid and serology methods for detection of Olpidium brassicae, vector of lettuce big-vein disease (LBVD), during various phases of lettuce seedling production in nursery environments. It will be the first study to develop sustainable and environmentally responsible nursery best-practice protocols for integrated management of O. brassicae in routine seedling production and for management within the lettuce industry. These protocols will ensure that the spread of LBVD from contaminated lettuce nurseries to farms is prevented. It will also be a unique study of the establishment of a disease in new land with different soils and agricultural practices.Read moreRead less
Functional proteomics of Giardia. This project will use the latest tools for dissecting and comparing genes and their protein products from one of the most common parasites infecting people, their pets, livestock and wildlife. This protozoan parasite Giardia is also of evolutionary and biological significance in terms of understanding the origin of higher animals from bacteria as well as fundamental questions about the parasitic way of life. Giardia proteins will be identified and characterised ....Functional proteomics of Giardia. This project will use the latest tools for dissecting and comparing genes and their protein products from one of the most common parasites infecting people, their pets, livestock and wildlife. This protozoan parasite Giardia is also of evolutionary and biological significance in terms of understanding the origin of higher animals from bacteria as well as fundamental questions about the parasitic way of life. Giardia proteins will be identified and characterised on the basis of their value in understanding disease processes and treatment, and by working with appropriate industry partners, proteins of commercial value will be exploited.Read moreRead less
Race status, sources of resistance and mechanisms of resistance to Peronospora parasitica, a major threat to oilseed Brassica production in Australia. Through successful identification of mechanisms and molecular characterisation of resistance to Peronospora parasitica races and the identification of sources of host resistance against these races, breeders, for the first time, will be able to develop cultivars with resistance against the full spectrum of P. parasitica races occurring across sout ....Race status, sources of resistance and mechanisms of resistance to Peronospora parasitica, a major threat to oilseed Brassica production in Australia. Through successful identification of mechanisms and molecular characterisation of resistance to Peronospora parasitica races and the identification of sources of host resistance against these races, breeders, for the first time, will be able to develop cultivars with resistance against the full spectrum of P. parasitica races occurring across southern Australia. Benefits include prevention of severe losses in canola from downy mildew, and more viable and sustainable production with less reliance upon fungicides. This research addresses the National Research Priority 'An Environmentally Sustainable Australia' and the Priority Goal of 'Transforming existing industries', and will particularly benefit southern Australian rural communities.Read moreRead less
Race status, resistance mechanisms, and new sources of resistance to Phytophthora clandestina, a major threat to subterranean clover production. Devastating outbreaks of disease caused by Phytophthora clandestina (Phytophthora root rot) since the late 1970s demonstrated the capacity of this disease to impact severely on clover pasture production across southern Australia, particularly as new races of Phytophthora have rapidly emerged to overcome the resistance of all commercial cultivars. The p ....Race status, resistance mechanisms, and new sources of resistance to Phytophthora clandestina, a major threat to subterranean clover production. Devastating outbreaks of disease caused by Phytophthora clandestina (Phytophthora root rot) since the late 1970s demonstrated the capacity of this disease to impact severely on clover pasture production across southern Australia, particularly as new races of Phytophthora have rapidly emerged to overcome the resistance of all commercial cultivars. The proposed research seeks to delineate new races of the pathogen, to identify the histological and biochemical mechanisms by which resistance to Phytophthora root rot is expressed, and to identify new sources of host resistance. This proposed research will enable breeders, for the first time, to incorporate multiple types of resistance and against different races into new host varieties.Read moreRead less
The development of mass spectrometry techniques for mapping post-translational modifications in the wheat pathogen Stagonospora nodorum. The fungus Stagonospora nodorum is a significant pathogen of wheat causing in excess of $100 million dollars in yield losses per annum in Australia. This project will develop new analytical methods that can be used to detect important protein modifications in Stagonospora nodorum with the goal of securing Australia's wheat supply.
Applications-oriented elucidation of germination triggers for Emu Bush seed. The project aims to determine the environmental and genetic mechanisms that currently limit seed germination in Emu Bush (Eremophila) species. The anticipated project outcomes aim to develop new technologies for efficient and mass production of Emu Bush seedlings. The outcomes will improve land restoration by increasing plant diversity and reducing establishment costs, and will also provide the nursery industry with nov ....Applications-oriented elucidation of germination triggers for Emu Bush seed. The project aims to determine the environmental and genetic mechanisms that currently limit seed germination in Emu Bush (Eremophila) species. The anticipated project outcomes aim to develop new technologies for efficient and mass production of Emu Bush seedlings. The outcomes will improve land restoration by increasing plant diversity and reducing establishment costs, and will also provide the nursery industry with novel products for home gardens. The intended project benefits are to increase the diversity of Australian native plants used for restoration and ornamental purposes and to promote the conservation of species in this plant family and its genetic diversity.Read moreRead less
Development of technologies to monitor multimolecular complexes. Development of technologies to monitor multimolecular complexes. This project aims to develop technologies to monitor how proteins and their interacting molecules (such as hormones) form multi-component complexes, and how these complexes function in the cell, including movement from the cell surface, into different cellular compartments and back up to the surface. These technologies are expected to enable monitoring in live cells i ....Development of technologies to monitor multimolecular complexes. Development of technologies to monitor multimolecular complexes. This project aims to develop technologies to monitor how proteins and their interacting molecules (such as hormones) form multi-component complexes, and how these complexes function in the cell, including movement from the cell surface, into different cellular compartments and back up to the surface. These technologies are expected to enable monitoring in live cells in real-time with high sensitivity. This project could have broad benefits for and affect study of all aspects of the life sciences at the cellular and molecular levels. How these protein complexes function in cells underpins much of our understanding of biology, and technological tools.Read moreRead less
Better bees for tomorrow: A proteomic and physiological characterization of male fertility in managed versus feral honeybees in Western Australia. The importance of honeybees for food production is often undervalued as they pollinate more than 80 crops of economic interest. However, honeybee populations are on a worldwide decline and the beekeepers struggle to survive economically. Australia has so far been spared of major collapses but this seems merely a question of time. The work proposed ini ....Better bees for tomorrow: A proteomic and physiological characterization of male fertility in managed versus feral honeybees in Western Australia. The importance of honeybees for food production is often undervalued as they pollinate more than 80 crops of economic interest. However, honeybee populations are on a worldwide decline and the beekeepers struggle to survive economically. Australia has so far been spared of major collapses but this seems merely a question of time. The work proposed initiates a close collaboration between the only honeybee-breeding organization in Western Australia and the University of Western Australia. Scientific research to ensure a future supply of managed and healthy honeybees is initiated to understand honeybee reproduction, diseases and immunity in more detail. The results are expected to be of interest for the entire Australian honeybee industry.Read moreRead less
Safeguarding honeybees: understanding host-parasite interactions at the level of proteins. Parasites are responsible for dramatic declines of honeybee populations resulting in a loss of pollination services and posing a threat to food production and ecosystem stability. This project will study the honeybee immune system and its interactions with bee parasites on the molecular scale, which will be important to guide future bee breeding.
Proteomic techniques to assess oxidative stress in muscle wasting diseases. Australia will experience a significant increase in the proportion of its population that is over 65 years of age over the next 50 years. There will be an increased demand for health services related to injury from falls unless effective preventive strategies are put in place. Loss of muscle mass contributes to falls, so development of preventative strategies has the potential for considerable benefits. Oxidative stress ....Proteomic techniques to assess oxidative stress in muscle wasting diseases. Australia will experience a significant increase in the proportion of its population that is over 65 years of age over the next 50 years. There will be an increased demand for health services related to injury from falls unless effective preventive strategies are put in place. Loss of muscle mass contributes to falls, so development of preventative strategies has the potential for considerable benefits. Oxidative stress is a key intermediary in muscle wasting. This PhD project examines a possible mechanism by which oxidative stress causes muscle wasting. An appropriately tailored therapy to minimise oxidative stress has the potential to ameliorate loss of muscle mass.
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