Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100053
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an underst ....State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an understanding of the various methods available, and their capabilities and limitations, through systematic research projects. Very little research has been done in Australia and overseas in this area due to lack of facilities. This state-of-the-art testing equipment will provide Australian institutions with a cutting edge facility with portable equipment for NDT related research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100058
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materi ....Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materials are often subjected to existing confining stresses. The full-field optical techniques, with an ultra-high speed and resolution camera in the system, aims to assist the quantitative measurement of deformation fields including small strain induced in brittle material's failure and identification of constitutive parameters.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100101
Funder
Australian Research Council
Funding Amount
$744,697.00
Summary
New generation facility for impact testing. This project aims to develop a new generation, national-impact testing facility to study the impact response of civil and mechanical structures and components. This project expects to seek simultaneous, realistic impact scenarios with very high velocities, which were previously impossible. This will enhance the capability for innovative research on real-time behaviour of components/systems under high amplitude impacts to augment their protection throug ....New generation facility for impact testing. This project aims to develop a new generation, national-impact testing facility to study the impact response of civil and mechanical structures and components. This project expects to seek simultaneous, realistic impact scenarios with very high velocities, which were previously impossible. This will enhance the capability for innovative research on real-time behaviour of components/systems under high amplitude impacts to augment their protection through advanced materials. This project is essential for research on rational design philosophies and effective retrofitting of high-risk buildings, infrastructure and armoured vehicles. Benefits include the saving of lives and property through new knowledge from credible impact testing.Read moreRead less
Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon durin ....Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon during training and rehabilitation. The project aims to develop a better understanding of the loading conditions that optimise tendon metabolism. Based on this, it then intends to develop new technologies to estimate the mechanical behaviour of the human Achilles tendon in real time based on integrated use of wearable technology, and new training guidelines that will optimise human tendon adaptation.Read moreRead less
Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a yea ....Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a year in Australia alone. This project is a major joint effort by the Australian water industry and world-leading scientists to generate advanced knowledge and develop effective technologies for optimal odour and corrosion management in sewers, delivering large social, environmental and economic benefits.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560716
Funder
Australian Research Council
Funding Amount
$864,610.00
Summary
A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The o ....A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The outcome will be a strategically important Australian T-ray facility that will provide immediate and transparent nationwide access. Historically, industry is transformed every time a new part of the electromagnetic spectrum becomes accessible - T-rays are the next frontier.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC150100023
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Training Centre for Advanced Manufacturing of Prefabricated Housing. ARC Training Centre for Advanced Manufacturing of Prefabricated Housing. This training centre aims to unlock the potential for growth of Australia’s prefabricated building industry by creating a sustainable training ecosystem including both industry and universities. It seeks to enable the next generation of engineers and architects to apply advanced manufacturing principles to prefabricated modular buildings. This emerging ....ARC Training Centre for Advanced Manufacturing of Prefabricated Housing. ARC Training Centre for Advanced Manufacturing of Prefabricated Housing. This training centre aims to unlock the potential for growth of Australia’s prefabricated building industry by creating a sustainable training ecosystem including both industry and universities. It seeks to enable the next generation of engineers and architects to apply advanced manufacturing principles to prefabricated modular buildings. This emerging highly trained workforce, driven by the needs of the customer, should identify innovations in the use of advanced materials, designs for manufacturing, and assembly. The centre aims to secure a competitive advantage for Australia in the global value chain leading to local employment growth and increased exports of prefabricated products and services.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100010
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
National Facility for Cyclic Testing of High-speed Rail (FCTHSR). National facility for cyclic testing of high-speed rail: Frontier technologies in rail transport demand access to state-of-the-art testing facilities for track modelling. The proposed national Facility for Cyclic Testing of High-Speed Rail (FCTHSR) is internationally a first-of-its-kind and it will be designed and built in-house for examining an array of Australian ground conditions and integrated track components. This unique fac ....National Facility for Cyclic Testing of High-speed Rail (FCTHSR). National facility for cyclic testing of high-speed rail: Frontier technologies in rail transport demand access to state-of-the-art testing facilities for track modelling. The proposed national Facility for Cyclic Testing of High-Speed Rail (FCTHSR) is internationally a first-of-its-kind and it will be designed and built in-house for examining an array of Australian ground conditions and integrated track components. This unique facility will offer a national and international hub for industry-driven research and consulting. The project outcomes will propel more Australian researchers to be among the world-leaders of rail technologies providing better solutions to challenging track environments. Prototype testing will ensure safer and cost-effective track designs.Read moreRead less