We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Special Research Initiatives - Grant ID: SR0354551
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the ....ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the world's renewable energy industry. An effective structure for networking and for the exchange of people, information and research results will maintain and improve Australia's position in this rapidly growing industry.Read moreRead less
Erosion of embankment dams and dam spillways. In excess of $250M is spent annually to maintain, upgrade, improve safety and monitor performance of Australian dams. Improved methods for assessing both spillway and internal erosion, the cause of 50 per cent of embankment dam failures and incidents requiring repairs, will be developed, maximising dam safety and minimising maintenance expenditure.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560716
Funder
Australian Research Council
Funding Amount
$864,610.00
Summary
A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The o ....A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The outcome will be a strategically important Australian T-ray facility that will provide immediate and transparent nationwide access. Historically, industry is transformed every time a new part of the electromagnetic spectrum becomes accessible - T-rays are the next frontier.Read moreRead less
Understanding mud pumping in heavy haul railroads. This project aims to examine the factors that cause mud pumping and evaluate the effectiveness of sub-surface drainage to prevent rail track instability. Fast heavy haul operations (such as loads used in mining and agriculture) impart repeated loads on the natural formation that can result in mud pumping. If the build-up of water pressure becomes excessive this can cause track failure. Through an experimental program and field study, the mechani ....Understanding mud pumping in heavy haul railroads. This project aims to examine the factors that cause mud pumping and evaluate the effectiveness of sub-surface drainage to prevent rail track instability. Fast heavy haul operations (such as loads used in mining and agriculture) impart repeated loads on the natural formation that can result in mud pumping. If the build-up of water pressure becomes excessive this can cause track failure. Through an experimental program and field study, the mechanisms of mud pumping, incorporating train loads and frequencies, will be studied, and the role of vertically installed drains will be quantified for improved practical design. The project aims to contribute to improved track longevity and reduced maintenance costs, with a corresponding boost in rail productivity.Read moreRead less
Atomisation and Combustion Physics of Australian Bio-oils. Australia is highly dependent on fossil fuels for energy production and transport, and this dependence is growing. Wide spread substitution of liquid hydrocarbon fuels by indigenous renewable bio-oil has the potential to improve Australian's energy outlook and assist in reaching greenhouse gas targets. Understanding the interrelationships between the physical and chemical properties of bio-oil, its atomisation, droplet formation and com ....Atomisation and Combustion Physics of Australian Bio-oils. Australia is highly dependent on fossil fuels for energy production and transport, and this dependence is growing. Wide spread substitution of liquid hydrocarbon fuels by indigenous renewable bio-oil has the potential to improve Australian's energy outlook and assist in reaching greenhouse gas targets. Understanding the interrelationships between the physical and chemical properties of bio-oil, its atomisation, droplet formation and combustion physics is fundamental to the delivery of an efficient and reliable combustion process using this fuel. Measurements using laser based diagnostics of the atomisation flow, droplet formation and combustion process will provide the experimental data to understand this complex interrelationship.Read moreRead less
Special Research Initiatives - Grant ID: SR0354703
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Robotics Research Network (RRN). The RRN brings together all the best robotics research groups in Australia with the aim of fostering and coordinating cooperative research. The RRN integrates researchers from fields including machine perception, sensing, control, artificial intelligence and mechatronics. The RRN includes representation from twelve Universities, CSIRO and involvement of four ARC Centres. Programmes are proposed to share research facilities, to support training of research personn ....Robotics Research Network (RRN). The RRN brings together all the best robotics research groups in Australia with the aim of fostering and coordinating cooperative research. The RRN integrates researchers from fields including machine perception, sensing, control, artificial intelligence and mechatronics. The RRN includes representation from twelve Universities, CSIRO and involvement of four ARC Centres. Programmes are proposed to share research facilities, to support training of research personnel and promote cooperation in international research programmes. Robotics is already having a substantial impact in industries such as mining and agriculture. Robotics will, in future, offer benefits in areas such as health care, building systems, and defence.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453803
Funder
Australian Research Council
Funding Amount
$535,452.00
Summary
High Performance Optical and Electronic Coatings Facility. The main aim of this project is to establish a state-of-the-art optical and electronic coatings facility for the Australian optoelectronics and nanotechnology research community to develop novel technologies of interest to communications, information technology and nanotechnology industries. The facility will allow the fabrication of a range of active and passive devices including photonic integrated circuits. The facility is f ....High Performance Optical and Electronic Coatings Facility. The main aim of this project is to establish a state-of-the-art optical and electronic coatings facility for the Australian optoelectronics and nanotechnology research community to develop novel technologies of interest to communications, information technology and nanotechnology industries. The facility will allow the fabrication of a range of active and passive devices including photonic integrated circuits. The facility is flexible enough to allow the deposition of a range of dielectric and metal layers with different structural, optical and electrical characteristics of fundamental as well as applied interest. This facility may open up new opportunities to develop microcavities, nanocrystals, tunable lasers and detectors, novel cantilevers for atomic force microscopy.
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