Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drive ....Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drives low and high-level brain functions, i.e., creating a window into the mind. In the future, outcomes from this study could improve our understanding of mental disorders, advance computer brain interface technology, and inspire the next paradigm shift in artificial intelligence.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specif ....Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specificity and develop state-of-the-art modelling technologies to improve knowledge of environmental influence on endothelial cell fate and function. This should provide a new framework to modulate the adaptive capacities of endothelial cells and can potentially enable more predictive and targeted drug efficacy and safety testing.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100139
Funder
Australian Research Council
Funding Amount
$2,965,538.00
Summary
Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processe ....Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processes inside the cell, including proliferation, differentiation and migration. Exactly how the physical and chemical properties of ECMs on the outside of the cell modify the behaviour of a cell on the inside remains unclear. Outcomes would include a blueprint for synthetic ECMs, pushing the boundaries of materials development in the biological and life sciences.Read moreRead less
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100722
Funder
Australian Research Council
Funding Amount
$362,245.00
Summary
Enabling Novel Hydrogen Storage via Combustible Ice for a Low-Carbon Future. This project aims to develop a new method for sustainable hydrogen storage. Hydrogen is vital for decarbonising Australia's economy, yet finding an efficient way for hydrogen storage is a global challenge. This project seeks to encapsulate hydrogen effectively in water to produce hydrogen-carrying combustible ice for efficient large-scale hydrogen storage, taking the advantages of water as the safest and cheapest raw ma ....Enabling Novel Hydrogen Storage via Combustible Ice for a Low-Carbon Future. This project aims to develop a new method for sustainable hydrogen storage. Hydrogen is vital for decarbonising Australia's economy, yet finding an efficient way for hydrogen storage is a global challenge. This project seeks to encapsulate hydrogen effectively in water to produce hydrogen-carrying combustible ice for efficient large-scale hydrogen storage, taking the advantages of water as the safest and cheapest raw material. Expected outcomes are cutting-edge knowledge and a new pathway of hydrogen storage. This project would contribute to turning Australia’s abundant renewable energy resources into substantial economic and environmental benefits and promote Australia's competitive edge in the global transition toward a low-carbon future.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100817
Funder
Australian Research Council
Funding Amount
$458,460.00
Summary
Predicting internal erosion in dams using real-time coupled experiments. Internal erosion causes nearly half of embankment dam failures globally. This project aims to develop a mechanics-based understanding of internal erosion to overcome the limitations of existing empirical approaches that do not capture the underlying physics. By innovatively coupling computational and physical experiments in real-time, this project expects to generate new insights that identify the factors leading to the ini ....Predicting internal erosion in dams using real-time coupled experiments. Internal erosion causes nearly half of embankment dam failures globally. This project aims to develop a mechanics-based understanding of internal erosion to overcome the limitations of existing empirical approaches that do not capture the underlying physics. By innovatively coupling computational and physical experiments in real-time, this project expects to generate new insights that identify the factors leading to the initiation and continuation of internal erosion. The expected outcome of this project is a probabilistic framework able to predict the internal erosion process. This should significantly enhance and inform the design of erosion control measures and provide a holistic risk assessment for embankment dams.Read moreRead less