Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation ....Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation of results. While theoretical developments of this project are general, in the sense that they are not restricted to particular engineering disciplines, the four chosen applications closely align with two major research priorities namely An Environmental Sustainable Australia and Promoting and Maintaining Good Health.Read moreRead less
Crusty Seabeds: From (Bio-)Genesis To Reliable Offshore Design. The project aims to make deep water oil and gas developments safer and cheaper by understanding better the unique seabed ‘crust’ conditions that occur in Australian waters. By studying the biogenic, structural and mechanical properties of deepwater crusts in more detail than can be done in ‘live’ oil and gas projects, this project expects to make a step change in the understanding of these seabed crusts. Expected outcomes of this pr ....Crusty Seabeds: From (Bio-)Genesis To Reliable Offshore Design. The project aims to make deep water oil and gas developments safer and cheaper by understanding better the unique seabed ‘crust’ conditions that occur in Australian waters. By studying the biogenic, structural and mechanical properties of deepwater crusts in more detail than can be done in ‘live’ oil and gas projects, this project expects to make a step change in the understanding of these seabed crusts. Expected outcomes of this project include developing new seabed investigation and design approaches for these soils. This should provide significant benefits, by facilitating the design and installation of low-risk, yet low cost seabed infrastructure (e.g. pipelines, risers, shallow foundations etc.) in these problematical seabed typesRead moreRead less
Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material fail ....Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material failure associated with the high impact forces. Expected outcomes of the project include a conceptual framework and scientific-based design tool to predict the geotechnical performance of offshore installations. The research will provide the necessary scientific advances to install, moor and service offshore wind and wave energy devices more economically and efficiently.Read moreRead less
Development of Steel Fibre Reinforced Concrete (SFRC) material with spiral-shaped fibres. This project will develop new spiral-shaped steel fibres to be added in concrete to improve its strength, toughness, crack bridging, deformation and impact resistance capacities. It will create better concrete material for wide applications in construction to resist extreme loading conditions such as explosions and high-speed impacts.
Lifting objects off the seabed. This project aims to investigate the process of lifting objects off the seabed. Understanding this breakout process is the scientific basis for a variety of offshore applications such as oil and gas decommissioning, marine salvage and securing foundations under extreme storms. This project expects to advance the understanding of soil-fluid-structure interactions of this problem using innovative high-speed photography observations and advanced numerical coupled ana ....Lifting objects off the seabed. This project aims to investigate the process of lifting objects off the seabed. Understanding this breakout process is the scientific basis for a variety of offshore applications such as oil and gas decommissioning, marine salvage and securing foundations under extreme storms. This project expects to advance the understanding of soil-fluid-structure interactions of this problem using innovative high-speed photography observations and advanced numerical coupled analyses. Outcomes will include a numerical tool, verified against a high quality experimental database, to predict the breakout process and uplift required for pressing offshore challenges. The ability for Australia’s engineers to predict lift procedures more accurately will contribute to safer operations in Australian waters and to the more economic harnessing of ocean resources.Read moreRead less
Predicting the foundation performance of offshore jack-up drilling rigs in intermediate soils. The research outcomes will be a major step forward in creating safer operations of mobile platforms in our challenging seabed conditions. The new models and guidelines will assist engineers in the efficient expansion of our offshore oil and gas industry, with significant increased investment projected over the next five years.
Hybrid materials with tunable mechanical response via topological interlocking and embedded kinematic agents. The project investigates a new approach to materials design targeting the inner architecture of materials. Such materials will be multifunctional and responsive to external fields. Applications include sound- and vibration-absorbing cladding, morphing aerospace and automotive materials, and protective civil engineering structures.
Developing innovative concrete composites by upscaling material properties. This project aims to develop an upscaling process to correlate micro-nano properties of engineering materials to their comprehensive physicochemical properties based on systematic mechanical and statistical analysis approaches and nanoindentation technology. The process will enable assessing material mechanical and viscoelastic properties at a microscale level thus will generate a new knowledge in structural engineering ....Developing innovative concrete composites by upscaling material properties. This project aims to develop an upscaling process to correlate micro-nano properties of engineering materials to their comprehensive physicochemical properties based on systematic mechanical and statistical analysis approaches and nanoindentation technology. The process will enable assessing material mechanical and viscoelastic properties at a microscale level thus will generate a new knowledge in structural engineering discipline including health monitoring, assessment of existing structures, historical buildings, and strengthening and repairing materials in structures. The outcomes are a multiscale link model for upscaling material properties and a development of innovative reinforced concrete composites which are cost-effective and efficient.Read moreRead less
Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their inter ....Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).Read moreRead less