Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation ....Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation of results. While theoretical developments of this project are general, in the sense that they are not restricted to particular engineering disciplines, the four chosen applications closely align with two major research priorities namely An Environmental Sustainable Australia and Promoting and Maintaining Good Health.Read moreRead less
Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material fail ....Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material failure associated with the high impact forces. Expected outcomes of the project include a conceptual framework and scientific-based design tool to predict the geotechnical performance of offshore installations. The research will provide the necessary scientific advances to install, moor and service offshore wind and wave energy devices more economically and efficiently.Read moreRead less
A novel foundation to extend the operation of mobile structures into deeper water. Oil and gas is a key industry in Australia, contributing A$17 billion to the economy. However, with the large accessible reserves in shallower waters becoming exhausted, Australian oil and gas companies require new technologies to extend their capabilities. The research in this proposal addresses this concern, providing an extension of the operational depth range of mobile jack-up platforms from 120 to 200 m. This ....A novel foundation to extend the operation of mobile structures into deeper water. Oil and gas is a key industry in Australia, contributing A$17 billion to the economy. However, with the large accessible reserves in shallower waters becoming exhausted, Australian oil and gas companies require new technologies to extend their capabilities. The research in this proposal addresses this concern, providing an extension of the operational depth range of mobile jack-up platforms from 120 to 200 m. This creates the opportunity to develop the significant number of Australia's smaller gas fields that are currently uneconomical to exploit. The proposed project will contribute to the future competitiveness of Australia's oil and gas industry and ensuring energy supply for the sustained growth of the Australian economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100053
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an underst ....State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an understanding of the various methods available, and their capabilities and limitations, through systematic research projects. Very little research has been done in Australia and overseas in this area due to lack of facilities. This state-of-the-art testing equipment will provide Australian institutions with a cutting edge facility with portable equipment for NDT related research.Read moreRead less
Development of Steel Fibre Reinforced Concrete (SFRC) material with spiral-shaped fibres. This project will develop new spiral-shaped steel fibres to be added in concrete to improve its strength, toughness, crack bridging, deformation and impact resistance capacities. It will create better concrete material for wide applications in construction to resist extreme loading conditions such as explosions and high-speed impacts.
Lifting objects off the seabed. This project aims to investigate the process of lifting objects off the seabed. Understanding this breakout process is the scientific basis for a variety of offshore applications such as oil and gas decommissioning, marine salvage and securing foundations under extreme storms. This project expects to advance the understanding of soil-fluid-structure interactions of this problem using innovative high-speed photography observations and advanced numerical coupled ana ....Lifting objects off the seabed. This project aims to investigate the process of lifting objects off the seabed. Understanding this breakout process is the scientific basis for a variety of offshore applications such as oil and gas decommissioning, marine salvage and securing foundations under extreme storms. This project expects to advance the understanding of soil-fluid-structure interactions of this problem using innovative high-speed photography observations and advanced numerical coupled analyses. Outcomes will include a numerical tool, verified against a high quality experimental database, to predict the breakout process and uplift required for pressing offshore challenges. The ability for Australia’s engineers to predict lift procedures more accurately will contribute to safer operations in Australian waters and to the more economic harnessing of ocean resources.Read moreRead less
Braced batter micropile group: New design theory and performance framework. Braced batter micropile group: New design theory and performance framework. This project aims to research the design and performance of innovative biomimetic braced battered micropile group footings. This project will test Surefoot, the new concrete free footing, in the laboratory, in the field, and through numerical and analytical modelling. Surefoot’s mechanisms of action are poorly understood but clearly more complex ....Braced batter micropile group: New design theory and performance framework. Braced batter micropile group: New design theory and performance framework. This project aims to research the design and performance of innovative biomimetic braced battered micropile group footings. This project will test Surefoot, the new concrete free footing, in the laboratory, in the field, and through numerical and analytical modelling. Surefoot’s mechanisms of action are poorly understood but clearly more complex than current micropile theory; this project will research the mechanism of load transfer from micropiles to the soil and soil response.Read moreRead less
Predicting the foundation performance of offshore jack-up drilling rigs in intermediate soils. The research outcomes will be a major step forward in creating safer operations of mobile platforms in our challenging seabed conditions. The new models and guidelines will assist engineers in the efficient expansion of our offshore oil and gas industry, with significant increased investment projected over the next five years.