Industrial Transformation Training Centres - Grant ID: IC170100022
Funder
Australian Research Council
Funding Amount
$4,420,408.00
Summary
ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess a ....ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess and optimise the healing process. In addition, the Centre will produce data for use in deriving the next-generation of implants, giving rise to improved health outcomes, economic benefits, and a skilled workforce able to advance and perpetuate this important field.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Developing the basis for an quality control platform for human pluripotent stem cells and their differentiated derivatives. Biophotonic techniques based on spectroscopy have the potential to provide low-cost, automatable measurements for the quality control of stem and differentiated cells produced for use in industry and regenerative medicine. This project is aimed at acquiring the fundamental scientific knowledge base required to bring this about.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0228900
Funder
Australian Research Council
Funding Amount
$603,000.00
Summary
Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and b ....Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and barriers can perform safely when subjected to very heavy traffic and impact loads under laboratory and typical service conditions. This application seeks funds for establishing a unique hi-tech testing facility in Australia vital for advancing such infrastructure technology.Read moreRead less
Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tiss ....Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tissue, and quantitatively explain how wear is minimised in cartilage through weeping lubrication. This model will progress our understanding of cartilage mechanics in health and disease, and so help Australians age well and productively.Read moreRead less
Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct applicat ....Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct application in civil engineering as well as in environmental, mining and petroleum engineering which together make up a significant portion of the nation's industry.Read moreRead less
High Performance Twist Drill Design and Drilling Operations for Machining Mould Steel. In this project a high performance drill point design, based on low drilling forces and high drill-life criteria when machining mould steel will be developed together with a computer application software for drilling force predictions, based on the ¡®unified-generalised mechanics of cutting approach¡¯, and optimal drilling feed and speed selection for minimum cost and time per hole, based on a multi-constraint ....High Performance Twist Drill Design and Drilling Operations for Machining Mould Steel. In this project a high performance drill point design, based on low drilling forces and high drill-life criteria when machining mould steel will be developed together with a computer application software for drilling force predictions, based on the ¡®unified-generalised mechanics of cutting approach¡¯, and optimal drilling feed and speed selection for minimum cost and time per hole, based on a multi-constraint drilling optimization analysis. Particular attention will be given to the manufacture of the drill point geometry. It is anticipated that the application software will enable the drill design, manufacture, performance and drilling conditions to be integrated.Read moreRead less