Switching the light on cartilage repair. Osteoarthritis is a leading cause of pain and disability in adults and affects 15 per cent of the Australian population. This project will develop a revolutionary new approach to treat joint disorders using smart materials and stem cells. The novel materials and techniques developed will help Australia maintain its leading edge in biotechnology.
Development of new systems for the commercial collection, processing and storage of adipose stem cells. This project is aimed at developing a standardised method to commercially extract and expand stem cells from adipose tissue. This product will then be available commercially as a therapeutic treatment.
Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tib ....Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tibial defects. Furthermore, it will establish Australia's prominence in the tissue engineering field, training the next generation of young scientists and engineers. This technology will be of interest to numerous research groups and companies worldwide and will foster international collaboration, placing Australia at the forefront of this emerging field.Read moreRead less
Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key para ....Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key parameters involved in the improvement of subgrade soil by injecting lime-flyash slurry. This project will develop an improved design procedure for lime-flyash slurry injection in the field based on experimental and numerical modelling.Read moreRead less
Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assem ....Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assemblages in a controlled environment, and comprehensive analytical modelling of both loading and response. The outcomes from this research will have direct application to the mining, insurance, construction and defence industries.Read moreRead less
preventing reoccurrence of catastrophic failures of stormwater pipelines. This project aims to develop a technique to accurately predict the remaining safe life of deteriorated buried stormwater pipelines, thereby preventing their catastrophic failure. The research also aims to advance knowledge in deterioration science of reinforced concrete and failure theory of buried pipes. The outcomes are anticipated to be a suite of rational, practical and validated models for pipe deterioration as measur ....preventing reoccurrence of catastrophic failures of stormwater pipelines. This project aims to develop a technique to accurately predict the remaining safe life of deteriorated buried stormwater pipelines, thereby preventing their catastrophic failure. The research also aims to advance knowledge in deterioration science of reinforced concrete and failure theory of buried pipes. The outcomes are anticipated to be a suite of rational, practical and validated models for pipe deterioration as measured by crack growth and residual strength which are integrated in a time-dependent reliability method and coded as a computer program ready for take-up by end-users. Preventing catastrophic failures of buried pipes should deliver economic, environmental and social benefits.Read moreRead less
Improvement of the performance of water-sensitive geomaterials using hydrophobic additives. Geo-structures such as road and railway bases suffer from water induced damage because they readily interact with the atmosphere and shallow water tables. Under traffic loading, damage to geo-structures occurs as cracking, rutting and roughness, when the strength and stiffness of the geomaterials are compromised by on-going moisture variations. Substantial cost savings to the community can be made if ef ....Improvement of the performance of water-sensitive geomaterials using hydrophobic additives. Geo-structures such as road and railway bases suffer from water induced damage because they readily interact with the atmosphere and shallow water tables. Under traffic loading, damage to geo-structures occurs as cracking, rutting and roughness, when the strength and stiffness of the geomaterials are compromised by on-going moisture variations. Substantial cost savings to the community can be made if effective methods can be found to minimise such damage. This project proposes to study a novel technique, in which blends of hydrophobic polymer additives are used to increase the stability of geomaterials subjected to varying moisture levels and traffic loading.Read moreRead less
Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city enviro ....Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city environments. Expected outcomes include an effective pipe burst early warning system and the implementation of an active burst prevention and targeted pipe replacement strategy. This should significantly reduce the burst rates and associated interruptions in Adelaide and save millions of dollars every year in pipe relay programs.Read moreRead less
Rational lateral-bracing design for steel-framed domestic structures. For the 150,000 new Australian houses built annually to remain safe, despite expected increases in structural loading due to climate change, rational design approaches are desperately needed. This project will provide the industry with the necessary tools to develop optimised and innovative solutions to brace houses for extreme events and yet maintain affordability.