Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Functional Contribution Of Fetal Microchimeric Cells In Transgenic Models Of Maternal Tissue Repair In And After Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$542,462.00
Summary
Fetal stem cells cross into the mother during pregnancy and persist lifelong in her tissues. To determine whether helpful or harmful, we will study how these cells contribute to healing both after acute injury and in chronic genetic models like brittle-bone disease and muscular dystrophy. This research will inform long-term consequences of pregnancy, important for women's health and longevity, and help develop a promising form of stem cell therapy.
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a natio ....Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a nationally significant construction material known as Autoclaved Aerated Concrete. The material technologies developed by this research will lead to more efficient material use, a more sustainable materials solution and the potential to export the technology worldwide.Read moreRead less
Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport ne ....Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport near the sediment-water interface by a single domain approach, and link wave-dirven advective flow and contaminant in marine sediments. The research outcomes will provide a better prediction of the transformation behaviour of pollutants in contaminated sediments.Read moreRead less
Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian ....Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian history. The primary aim of this research project is to apply recently developed computational tools to better understand 3D slope behaviour and to develop rigorous stability solutions that can be used by design engineers. A better understanding of 3D slope failure will lead to more economic and safer slope designs.Read moreRead less
Modelling of sand wave migration and its interaction with pipelines. The movement of sand due to sand waves can interfere with marine structures such as pipelines and cables on the seabed. It may also cause free spans of pipelines, with potentially serious consequences. Most previous research has considered sand wave propagation and the stability of pipelines as separate problems. In this project, we propose a coupled analysis of sand wave migration and its interaction with pipelines through mat ....Modelling of sand wave migration and its interaction with pipelines. The movement of sand due to sand waves can interfere with marine structures such as pipelines and cables on the seabed. It may also cause free spans of pipelines, with potentially serious consequences. Most previous research has considered sand wave propagation and the stability of pipelines as separate problems. In this project, we propose a coupled analysis of sand wave migration and its interaction with pipelines through mathematical and numerical modelling. The theoretical work will be supported by laboratory experiments. The resulting research will provide a better understanding of sand wave migration, beach profiles and the stability of pipelines.Read moreRead less
Coupling models for ocean waves, groundwater and porous seabeds interaction. The ocean waves, groundwater flow and porous seabeds interaction problem is vital for erosion control, saltily and biological activities in coastal regions. Most previous research has investigated the problem from individual aspects, rather than a coupling concept. In this study, we will develop advanced theoretical models for procedures of waves propagation, water table fluctuations and soil behaviour in a porous seabe ....Coupling models for ocean waves, groundwater and porous seabeds interaction. The ocean waves, groundwater flow and porous seabeds interaction problem is vital for erosion control, saltily and biological activities in coastal regions. Most previous research has investigated the problem from individual aspects, rather than a coupling concept. In this study, we will develop advanced theoretical models for procedures of waves propagation, water table fluctuations and soil behaviour in a porous seabed, and couple them in a model. A series of experiments will be conducted for the verification of the theoretical findings. The research outcomes will provide a better understanding of the interaction between ocean wave, groundwater flow and porous seabeds.Read moreRead less