Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and ch ....Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and chemical interactions that occur between the particle and the oil-water interface, and develop a more efficient explosive that can be produced continuously on a commercial scale.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100138
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems ....National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems. The facility may advance understanding of the fundamental behaviour of critical infrastructure exposed to impact loading and will foster innovations in design and construction. Applications may include improvement of the structural safety of infrastructure including railway networks, tunnels and bridges, and also the development of cost-effective and environmentally friendly building and construction materials. Read moreRead less
Erosion of embankment dams and dam spillways. In excess of $250M is spent annually to maintain, upgrade, improve safety and monitor performance of Australian dams. Improved methods for assessing both spillway and internal erosion, the cause of 50 per cent of embankment dam failures and incidents requiring repairs, will be developed, maximising dam safety and minimising maintenance expenditure.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100053
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an underst ....State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an understanding of the various methods available, and their capabilities and limitations, through systematic research projects. Very little research has been done in Australia and overseas in this area due to lack of facilities. This state-of-the-art testing equipment will provide Australian institutions with a cutting edge facility with portable equipment for NDT related research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100058
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materi ....Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materials are often subjected to existing confining stresses. The full-field optical techniques, with an ultra-high speed and resolution camera in the system, aims to assist the quantitative measurement of deformation fields including small strain induced in brittle material's failure and identification of constitutive parameters.Read moreRead less
Special Research Initiatives - Grant ID: SR0354805
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Research Network for Rehabilitation of Structures Using Advanced Materials and Frontier Technologies. There is an urgent need to rehabilitate existing structures that are considered inadequate in strength and serviceability. Frontier strengthening technologies (such as external post-tensioning and plate bonding) using conventional and advanced materials are being currently developed in Australia by different groups, but as yet not in a coordinated manner. The aim of this network is to bring tog ....Research Network for Rehabilitation of Structures Using Advanced Materials and Frontier Technologies. There is an urgent need to rehabilitate existing structures that are considered inadequate in strength and serviceability. Frontier strengthening technologies (such as external post-tensioning and plate bonding) using conventional and advanced materials are being currently developed in Australia by different groups, but as yet not in a coordinated manner. The aim of this network is to bring together a multi-disciplinary team with complementary strengths to provide an integrated solution for rehabilitation of structures. The core of the network focuses on design tools, linking the various technologies to provide appropriate rehabilitation and understanding of life cycle demands for major infrastructure.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100101
Funder
Australian Research Council
Funding Amount
$744,697.00
Summary
New generation facility for impact testing. This project aims to develop a new generation, national-impact testing facility to study the impact response of civil and mechanical structures and components. This project expects to seek simultaneous, realistic impact scenarios with very high velocities, which were previously impossible. This will enhance the capability for innovative research on real-time behaviour of components/systems under high amplitude impacts to augment their protection throug ....New generation facility for impact testing. This project aims to develop a new generation, national-impact testing facility to study the impact response of civil and mechanical structures and components. This project expects to seek simultaneous, realistic impact scenarios with very high velocities, which were previously impossible. This will enhance the capability for innovative research on real-time behaviour of components/systems under high amplitude impacts to augment their protection through advanced materials. This project is essential for research on rational design philosophies and effective retrofitting of high-risk buildings, infrastructure and armoured vehicles. Benefits include the saving of lives and property through new knowledge from credible impact testing.Read moreRead less