Magnetically controlled drug release from tissue scaffolds for the treatment of acute burns. Severe skin burns are frequently associated with functionally disabling scarring and the risk of death. New magnetically activated wound seals for the treatment of acute burns will be developed that reduce the need for frequent painful dressing changes and hence facilitate rapid healing with a significantly reduced chance of scarring.
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches ....Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches and wave barriers to dissipate wave propagation, and in structural engineering to estimate in-structure vibration level and design isolators for sensitive equipment housed within. The technique will involve fundamental advances in the scaled boundary finite-element method, as calculations will be performed in a moving reference frame.Read moreRead less
Future Proofing Transportation Infrastructure Assets. This project seeks to develop a model to predict construction project overruns. Transportation infrastructure assets are prone to cost and schedule overruns during their construction, which have negative impacts on asset owners and users. This project aims to develop a systemic model that can be used to determine the causal nature of cost and schedule overruns and their probability of occurrence. By enabling the predication of overruns, the p ....Future Proofing Transportation Infrastructure Assets. This project seeks to develop a model to predict construction project overruns. Transportation infrastructure assets are prone to cost and schedule overruns during their construction, which have negative impacts on asset owners and users. This project aims to develop a systemic model that can be used to determine the causal nature of cost and schedule overruns and their probability of occurrence. By enabling the predication of overruns, the project aims to ensure that the public and private sector are able to put in place mitigation strategies to reduce the impact of the economic and productivity issues that arise due to overruns.Read moreRead less
Numerical Modelling of Three-dimensional Scour below Offshore Pipelines. Australia's increasing offshore oil and gas exploration has demanded more accurate and reliable methods for evaluating the safety and serviceability of pipelines. Local scour around pipelines is one of the major causes of pipeline failures, and is a major concern in Australian waters. This project not only addresses these concerns in its direct application to the design and management of offshore pipelines, but also will co ....Numerical Modelling of Three-dimensional Scour below Offshore Pipelines. Australia's increasing offshore oil and gas exploration has demanded more accurate and reliable methods for evaluating the safety and serviceability of pipelines. Local scour around pipelines is one of the major causes of pipeline failures, and is a major concern in Australian waters. This project not only addresses these concerns in its direct application to the design and management of offshore pipelines, but also will contribute to the nation's development and competitiveness in offshore exploration, and produce high quality research students. The improved design and management of pipelines in Australian waters will reduce the risk of potential environmental damages caused by leaking gas and oil.Read moreRead less
Rapid structural condition assessment using adaptive model updating. The proposed project has potential to significantly enhance the accuracy with which the condition (and hence load bearing capacity) of existing infrastructure can be determined. By providing a technique of model updating that can be applied effectively in real time, location of damage will be able to be determined accurately. Economic benefits will be reaped, both through saving infrastructure from demolition where the conditio ....Rapid structural condition assessment using adaptive model updating. The proposed project has potential to significantly enhance the accuracy with which the condition (and hence load bearing capacity) of existing infrastructure can be determined. By providing a technique of model updating that can be applied effectively in real time, location of damage will be able to be determined accurately. Economic benefits will be reaped, both through saving infrastructure from demolition where the condition is found to be adequate, and by replacing or repairing inadequate structures before costly failure occurs. This is particularly important as much of Australia's infrastructure is aging, and unnecessary periodic replacement of infrastructure is not sustainable.Read moreRead less
Efficient reinforced concrete design using linear elastic finite element analysis. It is expected that this project will bring about changes in the design practice for reinforced concrete structures, particularly those of complex geometry, which will enhance the competitiveness of the Australian design community. Through reduction of the overuse of concrete often present in current conservative design procedures for such structures, the project will lead to a reduction in the impact of reinforce ....Efficient reinforced concrete design using linear elastic finite element analysis. It is expected that this project will bring about changes in the design practice for reinforced concrete structures, particularly those of complex geometry, which will enhance the competitiveness of the Australian design community. Through reduction of the overuse of concrete often present in current conservative design procedures for such structures, the project will lead to a reduction in the impact of reinforced concrete construction on the environment and contribute to sustainable engineering practise.Read moreRead less
Blast Damage and Fragmentation Prediction for Occupants and Structure Protection. Protecting infrastructures against blast loads from terrorist bombing or accidental explosion is a challenge. Researchers have been working on developing a numerical model, but the progress is slow owing to difficulties in modelling nonlinear and high strain rate damage process. Most blast effect assessment is based on empirical relations from blast tests. These have been demonstrated not necessarily yielding accur ....Blast Damage and Fragmentation Prediction for Occupants and Structure Protection. Protecting infrastructures against blast loads from terrorist bombing or accidental explosion is a challenge. Researchers have been working on developing a numerical model, but the progress is slow owing to difficulties in modelling nonlinear and high strain rate damage process. Most blast effect assessment is based on empirical relations from blast tests. These have been demonstrated not necessarily yielding accurate prediction owing to variations of structural properties from the test model. A reliable numerical model is therefore important. It will result in big savings from blast tests, and better prediction of blast effects for structure and occupant protection. It will have applications in civil, mining and defence engineering. Read moreRead less
NUMERICAL ANALYSIS OF DYNAMIC REPONSE AND DAMAGE OF FRAME STRUCTURES TO EXPLOSIVE LOADS. Understanding structural response to explosive loads is essential to protect critical infrastructure against terrorist bombing or industrial explosions. Current practice in analysis and design of structures to withstand explosive loads uses either empirical methods or a simplified structure model. In many cases, engineers need to know the structure response in more detail in order to protect the structure an ....NUMERICAL ANALYSIS OF DYNAMIC REPONSE AND DAMAGE OF FRAME STRUCTURES TO EXPLOSIVE LOADS. Understanding structural response to explosive loads is essential to protect critical infrastructure against terrorist bombing or industrial explosions. Current practice in analysis and design of structures to withstand explosive loads uses either empirical methods or a simplified structure model. In many cases, engineers need to know the structure response in more detail in order to protect the structure and plan evacuation procedures. This project will study the response and damage mechanism of structures to explosive loads, and develop a numerical model to predict structural response and damage. It will have immediate and wide-ranging applications in defence, construction and mining engineering.Read moreRead less
Ageing of pile shaft friction in sand. Piles driven in sand are very commonly used to support structures in Australia. Their design, however, is based on pile capacities measured shortly after installation - even though capacities are observed to increase significantly with time. This proposal seeks to develop a methodology through which the effects of time can be incorporated in design and hence lead to cheaper foundation solutions.