Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus t ....Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus to alter stem cell aging and fate. The findings will provide critical information required for the future development of assays to measure cell potency and instructive biomaterials to drive stem cell expansion and tissue-regeneration and will have impact by underpinning future advances in stem cell technologies.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanism ....Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanisms for large scale stem cell differentiation. The expected outcomes are a significant advancement in knowledge in the field of tissue engineering and more efficient methodology for patient-derived stem cell therapy. This will provide new pathways to improving stem cell therapy for tissue engineering applications.Read moreRead less
How do transcription factors control cell fate transitions? The aim of this project is to determine how transcription factors control cellular identity, which is relevant to many biological processes including embryogenesis, cellular reprogramming and differentiation. Innovative genomic tools will be combined with various in vitro cellular conversion systems to generate fundamental mechanistic insight into how transcription factors mediate these identity changes. The knowledge gained from this w ....How do transcription factors control cell fate transitions? The aim of this project is to determine how transcription factors control cellular identity, which is relevant to many biological processes including embryogenesis, cellular reprogramming and differentiation. Innovative genomic tools will be combined with various in vitro cellular conversion systems to generate fundamental mechanistic insight into how transcription factors mediate these identity changes. The knowledge gained from this work will allow us to answer standing fundamental questions in regards to cell fate control and the biochemistry of transcription factors, which in turn will aid in the development of novel gene regulation technologies applicable to a myriad of fields and industries.Read moreRead less
Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and pl ....Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and planning of engineering processes in fractured porous media will be increased to the point that costly over/under designs are avoided. Through the use of the tools developed, it will be possible to detect weaknesses in the design, assess the impact and implement effective measures to improve performance.Read moreRead less
Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to ....Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to safe, affordable, and environmentally sustainabe modular building construction. The project will provide significant benefits to designers, manufacturers and regulators to improve the resilience of the building stock and to support greater design and manufacturing innovations.Read moreRead less
Next-generation smart water network for performance-driven asset management. This project aims to develop smart water network systems and techniques for continuous monitoring and early detection of structural failure in water distribution systems. Water assets are critical infrastructure, and they consist of a network of buried pipes that are old and deteriorating, with an annual maintenance overhead exceeding $1billion per year in Australia. This project is expected to deliver next-generation s ....Next-generation smart water network for performance-driven asset management. This project aims to develop smart water network systems and techniques for continuous monitoring and early detection of structural failure in water distribution systems. Water assets are critical infrastructure, and they consist of a network of buried pipes that are old and deteriorating, with an annual maintenance overhead exceeding $1billion per year in Australia. This project is expected to deliver next-generation smart water technology that enables continuous assessment of the actual performance of water pipe networks, guide “just in time” pipe replacement and optimise operations. This technology will assist asset managers to make informed decisions, strategically prioritise investment and extend asset life.Read moreRead less
Smart Pipe Condition Assessment in Water Distribution Systems. The project aims to develop an urgently needed smart pipe fault diagnosis, characterisation and prognosis system. Analysis techniques will be used for the detailed mapping of buried pipe condition between access points using micro-sized transient pressure waves. Water assets are critical infrastructure and they consist of a network of pipes that are often old and deteriorating. The annual maintenance cost exceeds $1b per year in Aus ....Smart Pipe Condition Assessment in Water Distribution Systems. The project aims to develop an urgently needed smart pipe fault diagnosis, characterisation and prognosis system. Analysis techniques will be used for the detailed mapping of buried pipe condition between access points using micro-sized transient pressure waves. Water assets are critical infrastructure and they consist of a network of pipes that are often old and deteriorating. The annual maintenance cost exceeds $1b per year in Australia. The outcome will be a next-generation tool that allows water utilities to move from reactive emergency repairs to proactive repair and predictive replacement. This will enable performance-driven asset management, extending asset life and replacing deteriorated high-risk pipe sections in a timely manner.Read moreRead less
A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing ....A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing pad which can be used as the next generation combat helmet liners and accessories. The novel high-performance energy absorption system will have a wide range of direct applications in future personal armour, as well as sports gears and elderly healthcare products.Read moreRead less
Assessing Water Supply Security in a Nonstationary Environment. About 25% of the global population currently has inadequate access to safe and secure water. This number is expected to rise to 50% by 2050 due to increased populations and reduced river flows. While a visible water crisis (such as the one in Cape Town in 2018) can culminate in the funding of new water supply infrastructure, a planned push for infrastructure augmentation often stalls due to contradictory projections of how much wate ....Assessing Water Supply Security in a Nonstationary Environment. About 25% of the global population currently has inadequate access to safe and secure water. This number is expected to rise to 50% by 2050 due to increased populations and reduced river flows. While a visible water crisis (such as the one in Cape Town in 2018) can culminate in the funding of new water supply infrastructure, a planned push for infrastructure augmentation often stalls due to contradictory projections of how much water will be available in the future. To address this, a novel alternative for assessing water security is proposed. Our approach assesses change using historical information on river flow and water demand, adapting these to form projections that exhibit greater reliability than currently existing alternatives.Read moreRead less